RESEARCH PAPER
Figure from article: The role of...
 
KEYWORDS
TOPICS
ABSTRACT
Introduction and objective:
The deep inferior epigastric perforator (DIEP) flap is widely used in breast reconstruction and offers advantages such as muscle preservation and a sufficient tissue volume for coverage. However, complications such as thrombosis and flap failure remain a concern in postoperative care. Thromboelastography (TEG)/Thromboelastometry (ROTEM) is a valuable tool for monitoring coagulation in the perioperative period, providing real-time data on clot formation, stability, and fibrinolysis.

Material and methods:
The study included 26 patients undergoing DIEP flap reconstruction, with ROTEM performed preoperatively, intraoperatively, and postoperatively. Clinical data and laboratory results were analyzed, with a particular focus on thromboelastometric parameters. Anticoagulation strategies were individually adjusted based on ROTEM findings.

Results:
ROTEM detected abnormal clotting profiles in a substantial proportion of patients. The use of ROTEM facilitated targeted intra-operative management, resulting in reduced thrombotic events and improved blood product utilization compared to conventional coagulation tests (CCTs). Flap-related complications were limited to one total flap loss (4%) and three instances of marginal necrosis (11%). These findings align with current evidence supporting the increasing role of visco-elastic testing in optimizing outcomes in microsurgical procedures.

Conclusions:
TEG/ROTEM provided more accurate and timely coagulation information than routine laboratory tests, leading to improved management of anticoagulation and reduced thrombotic complications in DIEP flap breast reconstruction. Proper perioperative management guided by ROTEM can minimize complications, such as thrombosis, while optimizing blood transfusion requirements and flap survival.
REFERENCES (24)
1.
Guinier C, de Clermont-Tonnerre E, Tay JQ, et al. The deep inferior epigastric artery perforator flap: a narrative review on its various uses in non-breast reconstruction. Ann Transl Med. 2023;11(2):130. https://doi.org/10.21037/atm-2....
 
2.
Tan MG, Isaranuwatchai W, DeLyzer T, et al. A cost-effectiveness analysis of DIEP vs free MS-TRAM flap for microsurgical breast reconstruction. J Surg Oncol. 2019;119(3):388–396. https://doi.org/10.1002/jso.25....
 
3.
Nahabedian MY. The deep inferior epigastric perforator flap: where we started and where we are now. Gland Surg. 2023;12(5):696–703. https://doi.org/10.21037/gs-22....
 
4.
Jacobs JED, Bargon CA, Rakhorst HA. The immediate-delayed deep inferior epigastric perforator (DIEP) flap: is it worth the extra step?—an expert’s opinion. Ann Breast Surg 2022;6:1. https://doi.org/doi.org/10.210....
 
5.
Shaydakov ME, Sigmon DF, Blebea J. Thromboelastography. 1st ed. Treasure Island (FL): StatPearls Publishing; 2023.
 
6.
Korpallová B, Samoš M, Bolek T, et al. Role of Thromboelastography and Rotational Thromboelastometry in the Management of Cardiovascular Diseases. Clin Appl Thromb Hemost. 2018;24(8):1199–1207. https://doi.org/10.1177/107602....
 
7.
Whitton TP, Healy WJ. Review of Thromboelastography (TEG): Medical and Surgical Applications. Ther Adv Pulm Crit Care Med. 2023;18:29768675231208426. https://doi.org/10.1177/297686....
 
8.
Drotarova M, Zolkova J, Belakova KM, et al. Basic Principles of Rotational Thromboelastometry (ROTEM®) and the Role of ROTEM-Guided Fibrinogen Replacement Therapy in the Management of Coagulopathies. Diagnostics (Basel). 2023;13(20):3219. https://doi.org/10.3390/diagno....
 
9.
Abdelfattah K, Cripps MW. Thromboelastography and Rotational Thromboelastometry use in trauma. Int J Surg. 2016;33(Pt B):196–201. https://doi.org/10.1016/j.ijsu....
 
10.
Crochemore T, Piza FMT, Rodrigues RDR, et al. A new era of thromboelastometry. Einstein (Sao Paulo). 2017;15(3):380–385. https://doi:10.1590/S1679-4508....
 
11.
Veigas PV, Callum J, Rizoli S, et al. A systematic review on the rotational thrombelastometry (ROTEM®) values for the diagnosis of coagulopathy, prediction and guidance of blood transfusion and prediction of mortality in trauma patients. Scand J Trauma Resusc Emerg Med. 2016;24(1):114. https://doi.org/10.1186/s13049....
 
12.
Calatazis A, Görlinger K, Spannagl M, et al. ROTEM® Analysis Targeted Treatment of Acute Haemostatic Disorders. 1st ed. Munich: tem® Redefining Bleeding Control; 2016.
 
13.
Thakkar M, Rose A, Bednarz B. Thromboelastography in Microsurgical Reconstruction: A Systematic Review. JPRAS Open. 2022;32:24–33. https://doi.org/10.1016/j.jpra....
 
14.
Thakkar M, Rose A, Bednarz B. Thromboelastography in Microsurgical Reconstruction: A Systematic Review. JPRAS Open. 2022;32:24.
 
15.
Vanags I, Stepanovs J, Ozolina A, et al. Thromboelastometry for Assessing Risks of Free Flap Thrombosis in Patients Undergoing Microvascular Surgery. Front Med (Lausanne). 2020;7:289. https://doi.org/10.3389/fmed.2....
 
16.
Hamidian Jahromi A, Arnold SH, Konofaos P. Applications of Thromboelastography (TEG) in Microsurgery: A Systemic Review and Meta-Analysis. Transl Clin Med. 2023;8(1):73–79.
 
17.
Tuaño KR, Yang JH, Fisher MH, et al. Venous Thromboembolism after DIEP Flap Breast Reconstruction: Review of Outcomes after a Postoperative Prophylaxis Protocol. Plast Reconstr Surg. 2024;154(1):13e-20e. https://doi.org/10.1097/PRS.00....
 
18.
Zavlin D, Steinberg AJ, Chegireddy V, et al. Two successful cases of DIEP flaps for breast reconstruction in patients with Factor V Leiden. J Surg Case Rep. 2018;2018(9):rjy231. https://doi.org/10.1093/jscr/r....
 
19.
Parker RJ, Eley KA, Von Kier S, et al. Functional fibrinogen to platelet ratio using thromboelastography as a predictive parameter for thrombotic complications following free tissue transfer surgery: a preliminary study. Microsurgery. 2012;32(7):512–519. https://doi.org/10.1002/micr.2....
 
20.
Kolbenschlag J, Daigeler A, Lauer S, et al. Can rotational thromboelastometry predict thrombotic complications in reconstructive microsurgery? Microsurgery. 2014;34(4):253–260. https://doi.org/10.1002/micr.2....
 
21.
Zavlin D, Chegireddy V, Jubbal KT, et al. Management of Microsurgical Patients using Intraoperative Unfractionated Heparin and Thromboelastography. J Reconstr Microsurg. 2019;35(3):198–208. https://doi.org/10.1055/s-0038....
 
22.
Wikner J, Beck-Broichsitter BE, Schlesinger S, et al. Thromboelastometry: A contribution to perioperative free-flap management. J Craniomaxillofac Surg. 2015;43(7):1065–1071. https://doi.org/10.1016/j.jcms....
 
23.
Ekin Y, Günüşen İ, Özdemir ÖY, et al. Effect of Coagulation Status and Co-Morbidity on Flap Success and Complications in Patients with Reconstructed Free Flap. Turk J Anaesthesiol Reanim. 2019;47(2):98–106. https://doi.org/10.5152/TJAR.2....
 
24.
Zhang Y, Zeng J, Bao S, et al. Cancer progression and tumor hypercoagulability: a platelet perspective. J Thromb Thrombolysis. 2024;57(6):959–972. https://doi.org/10.1007/s11239....
 
eISSN:1898-2263
ISSN:1232-1966
Journals System - logo
Scroll to top