0.829
IF
20
MNiSW
166.26
ICV
 
 

Antinuclear antibodies among eastern-Polish rural inhabitants.

 
1
Instytut Medycyny Wsi, ul. Jaczewskiego 2, 20-090 Lublin, Poland. spiewak@galen.imw.lublin.pl
Ann Agric Environ Med 2003;10(2):207–209
KEYWORDS:
ABSTRACT:
Rural inhabitants are exposed to considerable amounts of pesticides fromwater, soil and air. There are indications that exposure to pesticides may trigger production of antinuclearantibodies (ANA). Therefore, the question arises about the prevalence of ANA in this group. In 90 eastern-Polishrural inhabitants (RI) and 50 urban blood donors (BD), the presence of ANA in serum was tested usingEIA technique (Varelisa ReCombi ANA Profile). The frequency of ANA in the RI group was 2.5-fold higherthan in the BD group (p = 0.0175). Among RI, at least one autoantibody was detected in 30 % (95 % CI:20.5-39.5 %). Most frequently, this was anti-dsDNA (12.2 %; 95 %CI: 5.5-19.0 %), followed by SS-A/Ro(7.8 %; 2.2-13.3 %), RNP and Scl-70 (each 5.6 %; 0.8-10.3 %), Jo-1 (3.3 %; 0.0-7.0 %), Sm, SS-B/La, andCENP (each 2.2 %; 0.0-5.3 %). These figures are relatively high compared to studies of other random populations.In the BD group, at least one autoantibody was found in 12 % (95 %CI: 3.0-21.0 %). Most frequently, thiswas anti-SS-A/Ro (8 %; 95 %CI: 0.5-15.5 %), followed by dsDNA, RNP, and Scl-70 (each 2 %; 0.0-5.9 %).Neither Jo-1, Sm, SS-B/La, nor CENP-autoantibodies were found in this group. These figures place eastern-Polishblood donors in the middle of the range of prevalence observed among blood donors in other countries.The occurrence of antinuclear antibodies in eastern-Polish rural population is relatively high comparedto both eastern-Polish blood donors and other random populations. A possible explanation for this isthe long-term exposure to pesticides.
eISSN:1898-2263
ISSN:1232-1966