Endocrine disrupting micropollutants in water and their effects on human fertility and fecundity
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Institute of Rural Health, Lublin, Poland
Faculty of Health Sciences, Medical University, Lublin, Poland
Corresponding author
Grzegorz Raszewski   

Institute of Rural Health, Jaczewskiego 2, 20-090, Lublin, Poland
Ann Agric Environ Med. 2022;29(4):477-482
Introduction and objective:
Micropollutants (MPs) are defined as persistent and biologically-active substances which occur in the environment in trace amounts, mainly as a result of industrial processes and human domestic activity. The published experimental data prove that, among other things, MPs present in the environment may also affect and disturb hormonal balance in humans, resulting in impairment of the reproductive function. In addition to the many MPs disrupting endocrine function described in literature and which exert an effect on human reproductive function, the study presents a review of current literature concerning the exposure to Bisphenol A, phthalates, organochlorine pesticides, and pyrethroids.

Review methods:
Two independent authors searched in PubMed and Google scholar (any date until September 2022) for studies concerning chosen endocrine-disrupting MPs in water and their effects on human fertility and fecundity.

Brief description of the state of knowledge:
The review of the literature showed that EDMs present in the environment may create risk in the prenatal and postnatal development following premature birth, and exert a negative effect on fertility and reproductive functions in humans, especially during the perinatal period.

The presented review of literature indicates a negative effect of exposure to BPA, phthalates, OC and OP pesticides, as well as to pyrethroids, regarding human reproductive health. It also demonstrated considerable differences according to gender. Generally, there is a definitely stronger evidence for the presence of a cause-effect relationship between the discussed EDMs and a decreased fertility and fecundity in males. The negative effect of exposure to Bisphenol A, phthalates, selected organochlorine pesticides and pyrethroids appears to be quite well documented.

Geissen V, Mol H, Klumpp E, Umlauf G, Nadal M, Van Der Ploeg M, et al. Emerging Pollutants in the Environment: A Challenge for Water Resource Management. International Soil Water Conservation Res. 2015;3(1):57–65.
Król M, Dudziak M. Occurrence and determination of selected micropollutants in water environment regulated by directive 2000/60/WE. Inżynieria Ekologiczna. 2018;19:38–47.
Tröger R, Klöckner P, Ahrens L, Wiberg K. Micropollutants in drinking water from source to tap – Method development and application of a multiresidue screening method. Sci Total Environ. 2018;627:1404–1432.
Stamm C, Räsänen K, Burdon FJ, Altermatt F, Jokela J, Joss A, et al. Unravelling the impacts of micropollutants in aquatic ecosystems: Interdisciplinary studies at the interface of large-scale ecology. Adv Ecol Res. 2016;55:183–223.
Yilmaz B, Terekeci H, Sandal S, Kelestimur F. Endocrine disrupting chemicals: exposure, effects on human health, mechanism of action, models for testing and strategies for prevention. Rev Endocr Metab Disord. 2020;21(1):127–147.
Lin L, Yang H, Xu X. Effects of Water Pollution on Human Health and Disease Heterogeneity: A Review Front Environ Sci. 2022;10:880246.
Syafrudin M, Kristanti RA, Yuniarto A, Hadibarata T, Rhee J, Al-Onazi WA, et al.. Pesticides in Drinking Water-A Review. Int J Environ Res Public Health. 2021;18(2):468.
Stockholm convention on persistent organic pollutants 2001. dito_exists (access: 14.11.2022).
Global Affairs Canada: Water in developing countries. protection-protection_environnement/water-eau.aspx?lang=eng (access: 14.11.2022).
Olisah C, Okoh OO, Okoh AI. Global evolution of organochlorine pesticides research in biological and environmental matrices from 1992 to 2018: a bibliometric approach. Emerg Contam. 2019;5:157–167.
Hutter HP, Moshammer H. Pesticides Are an Occupational and Public Health Issue. Int J Environ Res Public Health. 2018;15(8):1650.
Bairán G, Rebollar-Pérez G, Chávez-Bravo E, Eduardo TE. Treatment Processes for Microbial Resistance Mitigation: The Technological Contribution to Tackle the Problem of Antibiotic Resistance. Int J Environ Res Public Health. 2020;17(23):8866.
Green MP, Harvey AJ, Finger BJ, Tarulli GA.Endocrine disrupting chemicals: Impacts on human fertility and fecundity during the peri-conception period. Environ Res.2020;194:110694.
Sartain CV and Hunt PA. An old culprit but a new story: bisphenol A and ‘’NextGen’’ bisphenols. Fertil Steril. 2016;106:820–826.
Crain DA, Janssen SJ, Edwards TM, Heindel J, Ho SM, Hunt P, et al. Female reproductive disorders: the roles of endocrine-disrupting compounds and developmental timing. Fertility and sterility. 2008;90:911–940.
Jefferson WN, Patisaul HB, Williams CJ. Reproductive consequences of developmental phytoestrogen exposure. Reproduction. 2012;143:247–260.
Soto AM, Sonnenschein C. Environmental causes of cancer: endocrine disruptors as carcinogens. Nat Rev Endocrinol. 2010;6:363–370.
de Cock M, Maas YG, van de Bor M. Does perinatal exposure to endocrine disruptors induce autism spectrum and attention deficit hyperactivity disorders? Review. Acta Paediatrica. 2012;101:811–818.
Boucher O, Muckle G, Bastien CH. Prenatal exposure to polychlorinated biphenyls: a neuropsychologic analysis. Environmental Health Perspectives. 2009;117:7–16.
Boas M, Main KM, Feldt-Rasmussen U. Environmental chemicals and thyroid function: an update. Current Opinion Endocrinol Diabetes Obesity. 2009;16:385–391.
Baillie-Hamilton PF. Chemical toxins: a hypothesis to explain the global obesity epidemic. J Altern Complement Med. 2002;8:185–192.
Casals-Casas C, Desvergne B. Endocrine disruptors: from endocrine to metabolic disruption. Annu Rev Physiol. 2011;73:135–162.
Agas D, Sabbieti MG, Marchetti L. Endocrine disruptors and bone metabolism. Arch Toxicol. 2013;87(4):735–51.
Bansal A, Henao-Mejia J, Simmons RA. Immune system: an emerging player in mediating effects of endocrine disruptors on metabolic health. Endocrinol. 2018;159(1):32–45.
Directive 2013/39/eu of the european parliament and of the council (access: 14.11.2022).
Gore AC, Chappell VA, Fenton SE, Flaws JA, Nadal A, Prins GS, et al. DC-2: the Endocrine Society’s second scientific statement on Endocrine-Disrupting Chemicals. Endocr Rev. 2015;36:E1–E150.
Smarr M, Kannan K, Louis GB. Endocrine disrupting chemicals and endometriosis. Fertil Steril. 2016;106:959–966.
Adoamnei E, Mendiola J, Vela-Soria F, Fernandez MF, Olea N, Jorgensen N, et al. Urinary bisphenol A concentrations are associated with reproductive parameters in young men. Environ Res. 2018;161:122–128.
Barakat R, Lin PC, Rattan S, Brehm E, Canisso IF, Abosalum ME, at el. Prenatal exposure to DEHP induces premature reproductive senescence in male mice. Toxicol Sci. 2017;156:96–108.
Rattan S, Zhou C, Chiang C, Mahalingam S, Brehm E, Flaws JA. Exposure to endocrine disruptors during adulthood: Consequences for female fertility. J Endocrinol. 2017;233:R109–R129.
Karwacka A, Zamkowska D, Radwan M, Jurewicz J. Exposure to modern, widespread environmental endocrine disrupting chemicals and their effect on the reproductive potential of women: An overview of current epidemiological evidence. Hum Fertil. 2017;22:2–25.
Gonsioroski A, Mourikes VE, Flaws JA. Endocrine Disruptors in Water and Their Effects on the Reproductive System. Int J Mol Sci. 2020;21(6):1929.
U.S. Environmental Protection Agency Risk Management for Bisphenol A (BPA). (access: 14.09.2022).
Mantzouki C, Bliatka D, Iliadou PK, Margeli A, Papassotiriou I, Mastorakos G, et al. Serum Bisphenol A concentrations in men with idiopathic infertility. Food Chem. Toxicol. 2019;125:562–565.
Moon S, Seo MY, Choi K, Chang YS, Kim SH, Park MJ. Urinary bisphenol A concentrations and the risk of obesity in Korean adults. Sci Rep. 2021;15;11(1):1603.
Ji H, Miao M, Liang H, Shi H, Ruan D, Li Y, et al. Exposure of environmental Bisphenol A in relation to routine sperm parameters and sperm movement characteristics among fertile men. Sci Rep. 2018;8:17548.
Omran GA, Gaber HD, Mostafa NAM, Abdel-Gaber RM, Salah EA. Potential hazards of bisphenol A exposure to semen quality and sperm DNA integrity among infertile men. Reprod Toxicol. 2018;81:188–195.
Radwan M, Wielgomas B, Dziewirska E, Radwan P, Kałużny P, Klimowska A, et al. Urinary Bisphenol a levels and male fertility. Am J Men’s Heal. 2018;12:2144–2151.
Mok-Lin E, Ehrlich S, Williams PL, Petrozza J, Wright DL, Calafat AM, et al. Urinary bisphenol A concentrations and ovarian response among women undergoing IVF. Int J Androl. 2009;33:385–393.
Lee SH, Kang SM, Choi MH, Lee J, Park MJ, Kim SH, et al. Changes in steroid metabolism among girls with precocious puberty may not be associated with urinary levels of bisphenol A. Reprod Toxicol. 2014;44:1–6.
Shen Y, Zheng Y, Jiang J, Liu Y, Luo X, Shen Z, et al. Higher urinary Bisphenol A concentration is associated with unexplained recurrent miscarriage risk: Evidence from a Case-Control Study in Eastern China. PLoS ONE. 2015;10:e0127886.
Philips EM, Santos S, Steegers EA, Asimakopoulos AG, Kannan K, Trasande L, et al. Maternal bisphenol and phthalate urine concentrations and weight gain during pregnancy. Environ Int. 2019;135:105342.
Wittassek M, Wiesmuller GA, Koch HM, Eckard R, Dobler L, Muller J, et al. Internal phthalate exposure over the last two decades – a retrospective human biomonitoring study. Int J Hyg Environ Health 2007;210:319–333.
Al-Saleh I, Coskun S, Al-Doush I, Al-Rajudi T, Abduljabbar M, Al-Rouqi R, et al. The relationships between urinary phthalate metabolites, reproductive hormones and semen parameters in men attending in vitro fertilization clinic. Sci Total Environ. 2019;658:982–995.
Wang YX, Zeng Q, Sun Y, You L, Wang P, Li M, et al. Phthalate exposure in association with serum hormone levels, sperm DNA damage and spermatozoa apoptosis: a cross-sectional study in China. Environ Res. 2016;150:557–565.
Liu L, Wang H, Tian M, Zhang J, Panuwet P, D’Souza PE, et al. Phthalate metabolites related to infertile biomarkers and infertility in Chinese men. Environ Pollut. 2017;231:291–300.
Wang C, Yang L, Wang S, Zhang Z, Yu Y, Wang M, Cromie M, Gao W, Wang S-L. The classic EDCs, phthalate esters and organochlorines, in relation to abnormal sperm quality: a systematic review with meta-analysis. Sci Rep. 2016;6:1–23.
Wang YX, Zeng Q, Sun Y, Yang P, Wang P, Li J, Huang Z, You L, Huang YH, Wang C, Li YF, Lu WQ. Semen phthalate metabolites, semen quality parameters and serum reproductive hormones: a cross-sectional study in China. Environ Pollut. 2016;211:173–182.
Machtinger R, Gaskins AJ, Racowsky C, Mansur A, Adir M, Baccarelli AA, Calafat AM, Hauser R. Urinary concentrations of biomarkers of phthalates and phthalate alternatives and IVF outcomes. Environ Int. 2018;111:23–31.
Messerlian C, Souter I, Gaskins AJ, Williams PL, Ford JB, Chiu YH, et al. Urinary phthalate metabolites and ovarian reserve among women seeking infertility care. Hum Reprod. 2016;31:75–83.
Minguez-Alarcon L, Messerlian C, Bellavia A, Gaskins AJ, Chiu YH, Ford JB, et al. Urinary concentrations of bisphenol A, parabens and phthalate metabolite mixtures in relation to reproductive success among women undergoing in vitro fertilization. Environ Int. 2019;126:355–362.
Liao KW, Kuo PL, Huang HB, Chang JW, Chiang HC, Huang PC. Increased risk of phthalates exposure for recurrent pregnancy loss in reproductive aged women. Environ Pollut. 2018;241:969–977.
Wen HJ, Chen CC, Wu MT, Chen M, Sun CW, Wu WC, et al. Phthalate exposure and reproductive hormones and sex-hormone binding globulin before puberty – phthalate contaminated-foodstuff episode in Taiwan. PloS One. 2017;12:e0175536.
Albert O, Huang JY, Aleksa K, Hales BF, Goodyer CG, Robaire B, et al. Exposure to polybrominated diphenyl ethers and phthalates in healthy men living in the greater Montreal area: a study of hormonal balance and semen quality. Environ Int. 2018;116:165–175.
Ein-Mor E, Ergaz-Shaltiel Z, Berman T, Goen T, Natsheh J, Ben-Chetrit A, et al. Decreasing urinary organophosphate pesticide metabolites among pregnant women and their offspring in Jerusalem: impact of regulatory restrictions on agricultural organophosphate pesticides use? Int J Hyg Environ Health. 2018;221:775–781.
Burns CJ, Pastoor TP. Pyrethroid epidemiology: a quality-based review. Crit Rev Toxicol. 2018;48:297–311.
Dereumeaux C, Saoudi A, Goria S, Wagner V, De Crouy-Chanel P, Pecheux M, et al. Urinary levels of pyrethroid pesticides and determinants in pregnant French women from the Elfe cohort. Environ Int. 2018;119:89–99.
Hu Y, Ji L, Zhang Y, Shi R, Han WC, Tse LA, et al. Shanghai Birth Cohort, S. Organophosphate and pyrethroid pesticide exposures measured before conception and associations with time to pregnancy in Chinese couples enrolled in the Shanghai birth cohort. Environ Health Perspect. 2018;126:077001.
Whitworth KW, Baird DD, Steiner AZ, Bornman RMS, Travlos GS, Wilson RE, et al. Anti-Mullerian Hormone and lifestyle, reproductive, and environmental factors among women in rural South Africa. Epidemiol. 2015;26:429–435.
Ye XQ, Liu L. Effects of pyrethroid insecticides on hypothalamic-pituitary-gonadal axis: a reproductive health perspective. Environ Pollut. 2019;245:590–599.
Araki A, Miyashita C, Mitsui T, Goudarzi H, Mizutani F, Chisaki Y, et al. Prenatal organochlorine pesticide exposure and the disruption of steroids and reproductive hormones in cord blood: the Hokkaido study. Environ Int. 2018;110:1–13.
Chen MW, Santos HM, Que DE, Gou YY, Tayo LL, Hsu YC, et al. Association between organochlorine pesticide levels in breast milk and their effects on female reproduction in a Taiwanese population. Int J Environ Res Publ Health. 2018;15:931.
Al-Hussaini TK, Abdelaleem AA, Elnashar I, Shabaan OM, Mostafa R, El-Baz M, et al. The effect of follicular fluid pesticides and polychlorinated biphenyls concentrations on intracytoplasmic sperm injection (ICSI) embryological and clinical outcome. Eur J Obstet Gynecol Reprod Biol. 2018;220:39–43.
Bapayeva G, Issayeva R, Zhumadilova A, Nurkasimova R, Kulbayeva S, Tleuzhan R. Organochlorine pesticides and female puberty in South Kazakhstan. Reprod Toxicol. 2016;65:67–75.
Kadhel P, Monfort C, Costet N, Rouget F, Thome JP, Multigner L. Chlordecone exposure, length of gestation, and risk of preterm birth. Am J Epidemiol. 2014;179:536–544.
Martenies SE, Perry MJ. Environmental and occupational pesticide exposure and human sperm parameters: a systematic review. Toxicology 2013;307:66–73.
Harchegani AB, Rahmani A, Tahmasbpour E, Kabootaraki HB, Rostami H, Shahriary A. Mechanisms of diazinon effects on impaired spermatogenesis and male infertility. Toxicol Ind Health. 2018;34: 653–664.
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