RESEARCH PAPER
The correlation between two potentially antagonistic human adipocytokines, WISP-1 and CTRP1, and their association with insulin resistance
1
Department of Public Health, University of Medical Sciences, Poznań, Poland
2
The Doctoral School of the Poznan University of Medical Sciences, Poland
3
Department of Internal Diseases, Metabolic Disorders and Hypertension, University of Medical Sciences, Poznań, Poland
4
Department of Laboratory Diagnostics, University of Medical Sciences, Poznań, Poland
5
Department of Treatment of Obesity, Metabolic Disorders and Clinical Dietetics, University of Medical Sciences, Poznań,
Poland
Corresponding author
Małgorzata Mirr
Department of Public Health, Poznan University of Medical Sciences, Święcicki St. 6, 60-781 Poznań, Poznań, Poland
Department of Public Health, Poznan University of Medical Sciences, Święcicki St. 6, 60-781 Poznań, Poznań, Poland
Ann Agric Environ Med. 2023;30(3):555-560
KEYWORDS
TOPICS
ABSTRACT
Introduction and objective:
Wnt-1 signaling pathway protein 1 (WISP-1) and complement-C1q TNF-related protein 1 (CTRP1) are adipokines with possible opposite effects in regulating insulin sensitivity. The study investigated the correlation between circulating WISP-1 and CTRP1 in non-diabetic patients. Correlations between adipokines concentrations and biochemical and anthropometric parameters were also studied.
Material and methods:
The cross-sectional study enrolled 107 adult patients without diabetes. Patients with obesity accounted for 52.3% of the study group. Clinical, anthropometric, and laboratory data, including serum levels of WISP-1 and CTRP1, were obtained.
Results:
The moderate positive correlation between serum WISP-1 and CTRP1 concentrations was observed (p<0.000001, r=0.49). The correlation was more substantial in non-obese patients than in the obese group (r=0.66 and r=0.36, respectively; p<0.01). Circulating CTRP1 correlated positively with fasting insulin, Homeostatic Model Assessment for Insulin Resistance (HOMA-IR), total cholesterol, HDL cholesterol, and LDL cholesterol (p<0.05). WISP-1 level correlated with total cholesterol and HDL cholesterol concentrations (p<0.05). There was no significant difference in WISP-1 and CTRP1 concentrations between the groups with and without insulin resistance. The concentrations of WISP-1 and CTRP1 were significantly higher in females than in males (p<0.05).
Conclusions:
WISP-1 and CTRP1 may represent interrelated factors that antagonistically affect insulin resistance.
Wnt-1 signaling pathway protein 1 (WISP-1) and complement-C1q TNF-related protein 1 (CTRP1) are adipokines with possible opposite effects in regulating insulin sensitivity. The study investigated the correlation between circulating WISP-1 and CTRP1 in non-diabetic patients. Correlations between adipokines concentrations and biochemical and anthropometric parameters were also studied.
Material and methods:
The cross-sectional study enrolled 107 adult patients without diabetes. Patients with obesity accounted for 52.3% of the study group. Clinical, anthropometric, and laboratory data, including serum levels of WISP-1 and CTRP1, were obtained.
Results:
The moderate positive correlation between serum WISP-1 and CTRP1 concentrations was observed (p<0.000001, r=0.49). The correlation was more substantial in non-obese patients than in the obese group (r=0.66 and r=0.36, respectively; p<0.01). Circulating CTRP1 correlated positively with fasting insulin, Homeostatic Model Assessment for Insulin Resistance (HOMA-IR), total cholesterol, HDL cholesterol, and LDL cholesterol (p<0.05). WISP-1 level correlated with total cholesterol and HDL cholesterol concentrations (p<0.05). There was no significant difference in WISP-1 and CTRP1 concentrations between the groups with and without insulin resistance. The concentrations of WISP-1 and CTRP1 were significantly higher in females than in males (p<0.05).
Conclusions:
WISP-1 and CTRP1 may represent interrelated factors that antagonistically affect insulin resistance.
ACKNOWLEDGEMENTS
This study was financed by a large research grant from
statutory funding for young researchers – doctoral students
of the Doctoral School of Poznań University of Medical
Sciences for 2021 (project number 4718).
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