RESEARCH PAPER
Quality of life in long-term survivors of early stage endometrial cancer
 
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1
Department of Obstetrics, Gynecology and Maternity Care, Medical University, Bialystok, Poland
2
Department of Rehabilitation, Medical University, Bialystok, Poland
3
Department of Clinical Molecular Biology, Medical University, Bialystok, Poland
 
Ann Agric Environ Med. 2017;24(3):513–516
KEYWORDS:
ABSTRACT:
Introduction:
Endometrial cancer (EC) is the most common gynaecological malignancy in developed countries. Effective treatment of the early stage of the disease is achieved by surgery alone. An increasing number of patients with EC become long-term survivors; therefore, the purpose of this study was to investigate the quality-of-life (QOL) of EC survivors.

Material and Methods:
A total of 328 survivors who had completed cancer treatment more than 3 years ago, and had previously completed questionnaires concerning QOL – European Organization for Research and Treatment of Cancer Quality of Life Questionnaire (EORTC QLQ-C30) and depression – Beck Depression Inventory-II (BDI-II). Patients were grouped into those with surgery alone or surgery with adjuvant radiotherapy. Responses were compared with 284 healthy women who were seen for standard gynaecologic screening examinations.

Results:
According to the presented results, the QOL of women with EC after surgical treatment was equal to that of healthy women in the control group. Treatment with adjuvant radiotherapy influenced the QOL, with the exception of emotional functioning (p=0.028). No statistically significant differences were found in scores on the BDI-II between groups for the cognitive-affective factor, the somatic factor, or the total sum score.

Conclusions:
The quality of life in EC survivors approximates that of healthy controls after 3 years post-surgical treatment. Patients treated for early stage EC should be informed about the anticipated good prognosis and the low risk of psychosocial and physical long-term effects. Cancer survivors who are treated by surgery and adjuvant radiotherapy may be especially at risk for emotional functioning problems.

CORRESPONDING AUTHOR:
Robert Terlikowski   
Department of Rehabilitation, Medical University, Bialystok, Poland
 
REFERENCES (31):
1. Jemal A, Bray F, Center MM, Ferlay J, Ward E, Forman D. Global cancer statistics. CA Cancer J Clin. 2011; 61(2): 69–90.
2. Boyle P, Levin B. World cancer report. Lyon: IARC Press, 2008.
3. Reports based on data of National Cancer Registry. The Maria Sklodowska – Curie memorial Cancer Center, Department of Epidemiology and Cancer Prevetion, National Cancer Registry 2008, http://epid.coi.waw.pl/krn.
4. Dobrzycka B, Terlikowski SJ, Mazurek A, Kowalczuk O, Niklinska W, Chyczewski L, Kulikowski M. Circulating free DNA, p53 antibody and mutations of KRAS gene in endometrial cancer. Int J Cancer. 2010; 127(3): 612–621.
5. Lu KH. Management of early-stage endometrial cancer. Semin Oncol. 2009; 36(2): 137–144.
6. Fagotti A, Ferrandina G, Longo R, Mancuso S, Scambia G. Minilaparotomy in early stage endometrial cancer: an alternative to standard and laparoscopic treatment. Gynecol Oncol. 2002; 86(2): 177–183.
7. Fakiris AJ, Randall ME. Endometrial carcinoma: the current role of adjuvant radiation. J Obstet Gynaecol. 2009; 29(2): 81–89.
8. Donnelly CM, Blaney JM, Lowe-Strong A, Rankin JP, Campbell A, McCrum-Gardner E, Gracey JH. A randomised controlled trial testing the feasibility and efficacy of a physical activity behavioural change intervention in managing fatigue with gynaecological cancer survivors. Gynecol Oncol. 2011 Jun 18. [Epub ahead of print].
9. von Gruenigen VE, Waggoner SE, Frasure HE, Kavanagh MB, Janata JW, Rose PG, Courneya KS, Lerner E. Liefstyle challenges in endometrial cancer survivorship. Obstet Gynecol. 2011; 117(1): 93–100.
10. Becker M, Malafy T, Bossart M, Henne K, Gitsch G, Denschlag D. Quality of life and sexual functioning in endometrial cancer survivors. Gynecol Oncol. 2011; 121(1): 169–173.
11. von Gruenigen VE, Gibbons HE, Kavanagh MB, Janata JW, Lerner E, Courneya KS. A randomized trial of a lifestyle intervention in obese endometrial cancer survivors: quality of life outcomes and mediators of behavior change. Health Qual Life Outcomes 2009; 7: 17.
12. Basen-Engquist K, Scruggs S, Jhingran A, Bodurka DC, Lu K, Ramondetta L, Hughes D, Carmack Taylor C. Physical activity and obesity in endometrial cancer survivors: associations with pain, fatigue, and physical functioning. Am J Obstet Gynecol. 2009; 200(3): 288.e1–8.
13. Bradley S, Rose S, Lutgendorf S, Costanzo E, Anderson B. Quality of life and mental health in cervical and endometrial cancer survivors. Gynecol Oncol. 2006; 100(3): 479–486.
14. Vaz AF, Pinto-Neto AM, Conde DM, Costa-Paiva L, Morais SS, Pedro AO, Esteves SB. Quality of life and menopausal and sexual symptoms in gynecologic cancer survivors: a cohort study. Menopause 2011; 18(6): 662–669.
15. Gonçalves V. Long-term quality of life in gynecological cancer survivors. Curr Opin Obstet Gynecol. 2010; 22(1): 30–35.
16. Courneya KS, Karvinen KH, Campbell KL, Pearcey RG, Dundas G, Capstick V, Tonkin KS. Associations among exercise, body weight, and quality of life in a population-based sample of endometrial cancer survivors. Gynecol Oncol. 2005; 97(2): 422–430.
17. Aaronson NK, Ahmedzai S, Bergman B, Bullinger M, Cull A, Duez NJ, Filiberti A, Flechtner H, Fleishman SB, de Haes JC, et al. The European Organization for Research and Treatment of Cancer QLQ-C30: a quality-of-life instrument for use in international clinical trials in oncology. J Natl Cancer Inst. 1993; 85(5): 365–376.
18. Fayers P, Aaronson NK, Bjordal K, Curran D and Groenvold M on behalf of the EORTC Quality of Life Study Group. EORTC QLQ-C30 Scoring Manual (Third edition). Brussels, EORTC Quality of Life Group, 2001, 86.
19. Beck AT, Steer RA, Ball R, Ranieri W. Comparison of Beck Depression Inventories -IA and -II in psychiatric outpatients. J Pers Assess. 1996; 67(3): 588–597.
20. Klee M, Machin D. Health-related quality of life of patients with endometrial cancer who are disease-free following external irradiation. Acta Oncol. 2001; 40(7): 816–24.
21. Jereczek-Fossa BA, Badzio A, Jassem J. Time without symptoms and toxicity (TWIST) analysis of adjuvant radiation therapy for endometrial cancer. Radiother Oncol. 2004; 72(2): 175–181.
22. van de Poll-Franse LV, Mols F, Essink-Bot ML, Haartsen JE, Vingerhoets AJ, Lybeert ML, van den Berg HA, Coebergh JW. Impact of external beam adjuvant radiotherapy on health-related quality of life for long-term survivors of endometrial adenocarcinoma: a population-based study. Int J Radiat Oncol Biol Phys. 2007; 69(1): 125–132.
23. Herwig R, Bruns F, Strasser H, Pinggera GM, Micke O, Rehder P, Gozzi C, Willich N, Hertle L. Late urologic effects after adjuvant irradiation in stage I endometrial carcinoma. Urology 2004; 63(2): 354–358.
24. Dunberger G, Lind H, Steineck G, Waldenström AC, Nyberg T, al-Abany M, Nyberg U, Avall-Lundqvist E. Fecal incontinence affecting quality of life and social functioning among long-term gynecological cancer survivors. Int J Gynecol Cancer 2010; 20(3): 449–460.
25. Harrison SE, Watson EK, Ward AM, Khan NF, Turner D, Adams E, Forman D, Roche MF, Rose PW. Primary health and supportive care needs of long-term cancer survivors: a questionnaire survey. J Clin Oncol. 2011; 29(15): 2091–2098.
26. Miller BE, Pittman B, Strong C. Gynecologic cancer patients’ psychosocial needs and their views on the physician’s role in meeting those needs. Int J Gynecol Cancer 2003; 13(2): 111–119.
27. Capelli G, De Vincenzo RI, Addamo A, Bartolozzi F, Braggio N, Scambia G. Which dimensions of health-related quality of life are altered in patients attending the different gynecologic oncology health care settings? Cancer 2002; 95(12): 2500–2507.
28. Miller BE, Pittman B, Case D, McQuellon RP. Quality of life after treatment for gynecologic malignancies: a pilot study in an outpatient clinic. Gynecol Oncol. 2002; 87(2): 178–184.
29. Pearman T. Quality of life and psychosocial adjustment in gynecologic cancer survivors. Health Qual Life Outcomes 2003; 1: 33.
30. Humeniuk E, Bojar I, Owoc A, Wojtyła A, Fronczak A. Psychosocial conditioning of depressive disorders in post-menopausal women. Ann Agric Environ Med. 2011;18(2):441–445.
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31. Simonelli LE, Fowler J, Maxwell GL, Andersen BL. Physical sequelae and depressive symptoms in gynecologic cancer survivors: meaning in life as a mediator. Ann Behav Med. 2008; 35(3):275–284.
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