RESEARCH PAPER
IMMUNOSTIMULATIVE EFFECTS OF REPEATED INHALATION EXPOSURE TO MICROVESICLE-BOUND ENDOTOXIN OF PANTOEA AGGLOMERANS
 
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1
Department of Occupational Biohazards, Institute of Agricultural Medicine, Lublin, Poland
2
Professor Emeritus, Department of Microbiology and Immunology, West Virginia University, Morgantown, WV, USA
3
Department of Immunology and Virology, Maria Curie- Skłodowska University, Lublin, Poland
CORRESPONDING AUTHOR
Jacek Dutkiewicz   

Department of Occupational Biohazards, Institute of Agricultural Medicine, Lublin, Poland
 
Ann Agric Environ Med. 2005;12(2):289–294
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ABSTRACT
Rabbits exposed repeatedly to aerosols of endotoxin-containing microvesicles (ECMV) of the outer membrane of the Pantoea agglomerans strain isolated from airborne grain dust showed a large increase in the concentration of circulating cytokines: total interferon (IFN), interleukin-1α (IL-1 α), and tumor necrosis factor a (TNFα). The increase was significantly higher compared to animals exposed to control saline (p<0.001). Aerosol exposure to ECMV also induced the formation of specific precipitin antibodies and lymphocyte activation. The results indicate strong immunomodulative properties of ECMVs produced in nature by Pantoea agglomerans bacteria, and heavily contaminating organic dusts
eISSN:1898-2263
ISSN:1232-1966