Acute respiratory distress syndrome (ARDS) in the course of influenza A/H1N1v infection – genetic aspects
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Military Institute of Hygiene and Epidemiology, Biological Threat Identification and Countermeasures Centre, Pulawy, Poland
BioVectis, Warsaw, Poland; Electron Microscopy Platform, Mossakowski Medical Research Centre, Polish Academy of Sciences, Warsaw, Poland
Department of Expert Medical Assistance with Emergency Medicine Unit, Medical University, Lublin, Poland
BioVectis, Warsaw, Poland
Department of Internal Medicine, Independent Public Clinical Hospital, Lublin, Poland
Ann Agric Environ Med 2013;20(4):711–714
Influenza is a contagious respiratory disease caused by viruses belonging to the family Ortomyxoviridae. Among the influenza viruses type A, B and C, the A type virus shows the most pathogenic potential. Its surface receptor glycoproteins, hemagglutinin (HA) and neuraminidase (NA), are characterized by high antigenic variation, thus a host organism cannot develop permanent resistance. The case is described of a male patient with severe acute respiratory distress syndrome in the course of influenza A/N1H1v infection, confirmed by virological molecular analysis. During diagnostic procedures based on the MSSCP genotyping it was observed that the WHO recommended RT-PCR kits and/or procedure of sample collection from patients for molecular investigation could lead to false positive A/H1N1 pandemic strain detection because of the co-amplification during the RT-PCR fragments of the human genome.
Katarzyna Naylor   
Department of Expert Medical Assistance with Emergency Medicine Unit, Medical University, Lublin, Poland
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