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CASE REPORT
Rare case of Richter’s syndrome localization in liver and thyroid of a patient with a chronic
lymphocytic leukemia (CLL) – Case report and literature
1
Chair and Department of Haematooncology and Bone Marrow Transplantation, Medical University, Lublin, Poland
2
Department of Clinical Transplantology, Medical University, Lublin, Poland
3
Chair and Department of Neurosurgery and Paediatric Neurosurgery, Medical University, Lublin, Poland
4
Chair and Department of Clinical Immunology, Medical University, Lublin, Poland
5
Chair and Department of Clinical Pathomorphology, Medical University, Lublin, Poland
6
Department of Otolaryngology and Laryngological Oncology, Medical University, Lublin, Poland
Corresponding author
Agnieszka Szymczyk
Chair and Department of Haematooncology and Bone Marrow Transplantation, Medical University of Lublin, Department of Clinical Transplatology, Medical University of Lublin
Chair and Department of Haematooncology and Bone Marrow Transplantation, Medical University of Lublin, Department of Clinical Transplatology, Medical University of Lublin
Ann Agric Environ Med. 2020;27(1):160-164
KEYWORDS
TOPICS
ABSTRACT
Richter’s syndrome (RS) is a rare complication in which chronic lymphocytic leukaemia (CLL) or small lymphocytic lymphoma (SLL) transforms into a more aggressive type of lymphoma – diffuse large B cell lymphoma (DLBCL), or Hodgkin’s lymphoma (HL). The review describes the clinical case of a patient with CLL and RS diagnosis. A computed tomography (CT) scan of the abdominal cavity detected numerous normodense areas in the liver. Simultaneously, ultrasound examination (USG) of the thyroid revealed the presence of a solid hypoechogenic lump. The material sampled from closed biopsies of liver and thyroid in both cases allowed the diagnosis of diffuse large B cell lymphoma (DLBCL). The liver and the thyroid are particularly rare locations of RS. However, those cases allowed the conclusion that RS may occur even in a very unexpected and less probable location.
REFERENCES (31)
1.
Rossi D, Spina V, Deambrogi C, et al. The genetics of Richter syndrome reveals disease heterogeneity and predicts survival after transformation. Blood 2011; 117: 3391–3401.
2.
Parikh SA, Kay NE, Shanafelt TD. How we treat Richter syndrome. Blood 2014: 123; 1647–1657.
3.
Robertson LE, Pugh W, O’Brien S, et al. Richter’s syndrome: a report on 39 patients. J Oncology 1993; 11: 1985–1989.
4.
Rossi D, Spina V, Deambrogi C, et al. The genetics of Richter syndrome reveals disease heterogeneity and predicts survival after transformation. Blood 2011; 117: 3391–340.
5.
Tsimberidou AM, O’Brien S, Kantarjian HM, et al. Hodgkin transformation of chronic lymphocytic leukemia: the M. D. Anderson Cancer Center experience. Cancer 2006; 107: 1294–302.
6.
Parikh SA, Kay NE, Shanafelt TD. How we treat Richter syndrome. Blood 2014; 123: 1647–1657.
7.
Mao Z, Quintanilla-Martinez L, Raffeld M, et al. IgVH mutational status and clonality analysis of Richter’s transformation: diffuse large B-cell lymphoma and Hodgkin lymphoma in association with B-cell chronic lymphocytic leukemia (B-CLL) represent 2 different pathways of disease evolution. Am J Surg Pathol. 2007; 31: 1605–1614.
8.
Rossi D, Cerri M, Capello D, et al. Biological and clinical risk factors of chronic lymphocytic leukaemia transformation to Richter syndrome. Br J Haematol. 2008; 142: 202–215.
9.
Parikh SA, Rabe KG, Call TG, et al. Diffuse large B-cell lymphoma (Richter syndrome) in patients with chronic lymphocytic leukaemia (CLL): a cohort study of newly diagnosed patients. Br J Haematol. 2013; 162: 774–782.
10.
Parikh SA, Shanafelt TD. Risk factors for Richter syndrome in chronic lymphocytic leukemia. Curr Hematol Malig Rep. 2014;9:294-299.
11.
Jain N. New Developments in Richter Syndrome. Clinical Advances in Hematology & Oncology 2015; 13: 220–222.
12.
Swords R, Bruzzi J, Giles, F. Recent advances in the diagnosis and therapy of Richter’s syndrome. Medical Oncology 2007; 24: 17–32.
13.
Tsimberidou AM, Keating MJ. Richter syndrome. Biology, incidence, and therapeutic strategies. Cancer 2005; 103: 216–228.
14.
Robertson LE, Pugh W, O’Brien S, et al. Richter’s syndrome: a report on 39 patients. J Oncol. 1993; 11: 1985–1989.
15.
Kossev P, Livolsi V. Lymphoid lesions of the thyroid: review in light of the revised European-American lymphoma classification and upcoming World Health Organization classification. Thyroid 1999; 9: 1273–1280.
16.
Graff-Baker A, Roman SA, Thomas DC, et al. Prognosis of primary thyroid lymphoma: demographics, clinical, and pathologic predictors of survival in 1,408 cases. Surgery 2009; 146: 1105–1115.
17.
Sangalli G, Serio G, Zampatti C, Lomuscio G, Colombo L. Fine needle aspiration cytology of primary lymphoma of the thyroid: a report of 17 cases. Cytopathology 2001; 12: 257–263.
18.
Thieblemont C, Mayer A, Dumontet C, et al. Primary thyroid lymphoma is a heterogeneous disease. J Clin Endocrinol Metab. 2002; 87: 105–111.
19.
Bocian A, Kopczynski J, Rieske P, et al. Simultaneous occurrence of medullary and papillary carcinomas of the thyroid gland with metastases of papillary carcinoma to the cervical lymph nodes and the coinciding small B-cell lymphocytic lymphoma of the lymph nodes-a case repor. Pol J Pathol. 2004; 55: 23–30.
20.
Reid-Nicholson M, Moreira A, Ramalingam P. Cytologic features of mixed papillary carcinoma and chronic lymphocytic leukemia/small lymphocytic lymphoma of the thyroid gland. Diagn Cytopathol. 2008; 36: 813–817.
21.
Shin J, Chute D, Milas M, et al. A rare case of chronic lymphocytic leukemia/small lymphocytic lymphoma presenting in the thyroid gland. Thyroid. 2010; 20: 1019–1023.
22.
Trumper L, Matthaei-Maurer DU, Knauf W, et al. Centroblastic lymphoma of the thyroid supervening long-lasting chronic lymphocytic leukemia (B-CLL) demonstration of biclonality by immunohistochemical and gene rearrangement analysis. Klin Wochenschr 1988; 66: 736–742.
23.
Reddy N, Thompson-Arildsen MA. Hodgkin’s lymphoma: Richter’s transformation of chronic lymphocytic leukemia involving the liver. J Clin Oncol. 2010; 28: 543–544.
24.
Tadmor T, Bejar J, Attias D, et al. Richter syndrome in chornic lymphocytic leukaemia manifesting only as tumorous hepatomegaly. Britsh J Haematol. 2011; 155: 135.
25.
Maryniak RK, Konecki R. 2 cases of Richter’s syndrome. Acta Haematol Pol. 1991; 22: 165–169.
26.
Reddy N, Thompson-Arildsen MA. Hodgkin’s lymphoma: Richter’s transformation of chronic lymphocytic leukemia involving the liver. J Clin Oncol. 2010; 28: 543–44.
27.
A. Salihoglu, M. Ozbalak, D. Keskin, et al. An Unusual Presentation of a Chronic Lymphocytic Leukemia Patient with 17p Deletion After Reduced-Intensity Transplantation: Richter Syndrome and Concomitant Graft-Versus-Host Disease—Case Report. Transplantation Proceedings 2013; 45: 2845–2848.
28.
Cohen Y, Da’as N, Libster D, et al. Large-cell transformation of chronic lymphocytic leukemia and follicular lymphoma during or soon after treatment with fludarabine-rituximab-containing regimens: natural history- or therapy-related complication? Eur J Haematol. 2002; 68: 80–83.
29.
Janssens A, Berth M, de Paepe P, et al. EBV negative Richter’s syndrome from a coexistent clone after salvage treatment with alemtuzumab in a CLL patient. Am J Hematol. 2006; 81: 706–712.
30.
Dreger P, Dohner H, Ritgen M, et al. Allogeneic stem cell transplantation provides durable disease control in poor-risk chronic lymphocytic leukemia: long-term clinical and MRD results of the German CLL Study Group CLL3X trial. Blood 2010; 116: 2438–2447.
31.
Kroft SH, Dawson DB, McKenna RW. Large cell lymphoma transformation of chronic lymphocytic leukemia/small lymphocytic lymphoma. A flow cytometric analysis of seven cases. Am J Clin Pathol. 2001; 115: 385–395.
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