The topic of SARS-CoV-2 coronavirus infections in children is still complex and not fully understood. Acute meningoencephalitis (ME) was not considered a common presentation of COVID-19 in paediatrics, however, over time, several paediatric patients with ME associated with SARS-CoV-2 coronavirus infection have been described. The case report describes the clinical case of a newborn admitted to the Neonatal Intensive Care Unit (NICU) on 11th day of life due to severe SARS-CoV-2 coronavirus infection, who experienced multiple seizure episodes. The patient was diagnosed with ME and hydrocephalus. In the absence of clinical improvement, despite the use of standard treatment, acetazolamide (ACZ) was used, achieving complete relief of seizures and gradual regression of hydrocephalus. This means that ACZ can be considered as an add-on therapy to standard treatment in cases of ME and postinflammatory hydrocephalus in the course of COVID-19 disease.
ABB – acid-base balance; ACV – aciclovir; ACZ – acetazolamide; ALP – alkaline phosphatase; AMP – ampicillin; ARDS – acute respiratory distress syndrome; CA – carbonate dehydratase; CMV – cytomagalovirus; CNS – central nervous system; CPE – carbapenamase-producing Enterobacteriaceae; CSF – cerebrospinal fluid; CTX – cefotaxime; ECG – electrocardiogram; EEG – electroencephalogram; FFP – fresh frozen plasma; FiO2 – oxygen concentration in the breathing mixture; FLC – fluconazole; FR – ferritin; GBS – group B Streptococcus; GM – gentamicin; HFNC – high-flow nasal cannula; IVH – intraventricular haemorrhage; LP – lumbar puncture; ME – meningoencephalitis; MP – meropenem; MRI – magnetic resonance imaging; MRSA – methicillin-resistant Staphylococcus aureus; MSSA – methicillin-sensitive Staphylococcus aureus; NICU – neonatal intensive care unit; PB – phenobarbital; PC – platelet concentrate; PIMS – paediatric inflammatory multisystem syndrome; PVH – periventricular haemorrhage; RAV – right axillary vein; RSV – respiratory syncytial virus; RT-PCR – real-time reverse transcription polymerase chain reaction; SI – singal intensity; TnT – troponin T; USG – ultrasonography; VAN – vancomycin
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