Nicotinism and quality of embryos obtained in in-vitro fertilization programmes
More details
Hide details
Department of Obstetrics, Gynecology and Obstetrical-Gynecological Nursing,Faculty of Nursing and Health Sciences, Medical University, Lublin, Poland
Non-Public Health Care Unit ‘Ovum Reproduction and Andrology’, Lublin, Poland
Ann Agric Environ Med. 2013;20(1):82–85
Introduction: According to the World Health Organization, infertility is defined as the inability to conceive following 12 months of regular unprotected sexual intercourse. Cigarette smoking, alcohol and drugs are the main stimulants exerting a negative effect on the male and female reproductive organs. Objective: The objective of the study was analysis of the effect of cigarette smoking by the women examined and their partners on the quality of embryos obtained in in vitro fertilization programmes. Material and methods: The study covered 54 women treated due to infertility. The database and statistical analyses were performed by means of computer software STATISTICA 7.1 (StatSoft, Poland). Results: The study showed that among 100% of the women examined, 24.07% smoked cigarettes. No statistically significant difference was observed between cigarette smoking by the women in the study (p=0.42), and the number of cigarettes smoked daily (p=0.52) and the total duration of smoking expressed in years (p=0.56). In addition, the study showed that 33.33% of respondents were exposed to passive nicotinism, while 66.67% were not exposed to passive smoking. In the group of women exposed to passive smoking, Class A embryos constituted 11.11%, Class B embryos – 83.38%, whereas Class C embryos – only 5.56%. A statistically significant relationship was noted between classes of embryos and exposure to passive nicotinism (p=0.03). Passive smoking results in the development of embryos of poorer quality. A significantly higher number of Class 2 embryos were produced from oocytes of women exposed to the effect of cigarette smoke, compared to Class 1. Among women at reproductive age, an active campaign should be carried out against nicotinism on behalf of their fertility and future maternity.
Gurunath S, Pandian Z, Anderson RA, Bhattacharya S. Defining infertility – a systematic review of prevalence studies. Hum Reprod. 2011; 17(5): 575-588.
Pawelczyk L, Sokalska A. Medyczne aspekty niepłodności oraz technik wspomaganego rozrodu. (In.). Gadzinowski J, Pawelczyk L, Wiśniewski J. Dawanie życia. Problemy wspomaganego rozrodu człowieka. (Medical aspects of infertility and assisted reproductive techniques) Wydawnictwo Naukowe UAM, Poznań, 2003.
Dechanet C, Anahory T, Mathieu-Daude JC, Quantin X, Reyftmann L, Hamamah S, Hedon B, Dechaud H. Effects of cigarette smoking on reproduction. Hum Reprod. 2010; 17(1): 76-95.
Serdyńska M, Pawelczyk L, Jędrzejczak P. Epidemiologia niepłodności. (In.). Słomko Z. (ed.). Ginekologia t. 2. (Gynaecology Vol. 2) Wydawnictwo Lekarskie PZWL, Warszawa, 2008.
Saldeen P, Sundstrom P. Would legislation imposing single embryo transfer be a feasible way to reduce the rate of multiple pregnancies after IVF treatment? Hum Reprod. 2005; 20(1): 4-8.
Van Roven E, Mangelschots K, De Neubourg D, Valkenburg M, Van de Meerssche M, Ryckaert G, Estermans W, Gerris J. Characterization of a top quality embryo, a step towards single-embryo transfer. Hum Reprod. 1999; 14(9): 2345-2349.
Van Royen E, Gerris J. Semen sample collection in medium and implantation rate following ICSI. Hum Reprod. 2001; 16(11): 2475-2476.
Ziebe S, Petersen K, Lindenberg S, Anderesen AG, Gabrielsen A, Andersen AN. Embryo morphology or cleavage stage: how to select the best embryos for transfer after in-vitro fertilization. Hum Reprod. 1997; 12(7): 1545-1549.
Jennings PC, Merriman JA, Beckett EL, Hansbro PM, Jones KT. Increased zona pellucid thickness and meiotic spindle disruption in oocytes from cigarette smoking mice. Hum Reprod. 2011; 26(4): 878-884.
Sépaniak S, Forges T, Monnier-Barbarino P. Cigarette smoking and fertility in women and men. Gynecol Obstet Fertil. 2006; 34(10): 945- 949.
Shiloh H, Lahav-Baratz S, Coifman M, Ishai D, Bidder D, WeinerMeganzi Z, Dirnfeld M. The impact of cigarette smoking on zona pellucida thickness of oocytes and embryos prior to transfer into the uterine cavity. Hum Reprod. 2004; 19(1): 157-159.
Shiveric KT. Cigarette smoking and reproductive and developmental toxicity. In Gupta RC. Reproductive and developmental toxicology. Academic Press/Elsevier Inc, London, 2011.
Soares SR, Melo MA. Cigarette smoking and reproductive function. Curr Opin Obstet Gynecol. 2008; 20(3): 281-291.
Depa-Martynów M, Pawelczyk L, Taszarek-Hauke G, Jósiak M, Derwich K, Jędrzejczak P. Wpływ palenia tytoniu na wyniki leczenia niepłodności u kobiet zakwalifikowanych do programu zapłodnienia pozaustrojowego IVF-ICSI. (Effect of smoking on the results of infertility treatment in women qualified for in virto fertilization programme). Prz Lek. 2005; 62(10): 973-975 (in Polish).
Depa – Martynów M, Jędrzejczak P, Taszarek-Hauke G, Jósiak M, Pawelczyk L.: Wpływ palenia papierosów na jakość komórek jajowych oraz stan zarodków w przebiegu programu zapłodnienia pozaustrojowego. (Effect of smoking on the quality of embryos during in virto fertilization programme). Prz Lek. 2006; 63(10): 838-840 (in Polish).
Gruber I, Just A, Birner M, Losch A. Effect of a woman’s smoking status on oocyte, zygote, and day 3 pre-embryo quality in in vitro fertilization and embryo transfer program. Fertil Steril. 2008; 90(4): 1249-52.