Infertility in the light of new scientific reports – focus on male factor

Piotr Szkodziak 1  ,  
Paweł Milart 1,  
3rd Chair and Department of Gynecology Medical University, Lublin, Poland
“Ovum” Reproduction and Andrology, Infertility Centre, Lublin, Poland
Ann Agric Environ Med 2016;23(2):227–230
Epidemiological data indicate that infertility is a problem of global proportions, affecting one- fifth of couples trying to conceive worldwide (60–80 mln). According to the trends observed, the problem is predicted to increase by another two million cases annually. In Poland, infertility-related issues are found in about 19% of couples, including 4% with infertility and 15% with limited fertility. Inability to conceive occurs equally in men and women (50%), irrespective of the direct cause. Although it is generally thought that reproductive issues concern women, infertility affects men and women equally. This study is an attempted to systematize knowledge about the role of the male factor in infertility, particularly current knowledge concerning the environmental factors of infertility. For this purpose, the Medline and CINAHL databases and the Cochrane Library was searched for articles published in English during the last 10 years, using the following keywords: infertility, male factor, semen examination and environmental factor of infertility.
Piotr Szkodziak   
3rd Chair and Department of Gynecology Medical University, Lublin, Poland
1. World Health Organization D of RH and R. WHO laboratory manual for the examination and processing of human semen. Fifth edition. Geneva; 2010.
2. Cocuzza M, Alvarenga C, Pagani R. The epidemiology and etiology of azoospermia. Clinics (Sao Paulo). 2013;68 Suppl 1:15–26.
3. Winters BR, Walsh TJ. The epidemiology of male infertility. Urol Clin North Am. 2014; 41(1): 195–204.
4. Bablok L, Dziadecki W, Szymusik I, Wolczynski S, Kurzawa R, Pawelczyk L, Jedrzejczak P, Hanke W, Kaminski P, Wielgos M. Patterns of infertility in Poland – multicenter study. Neuro Endocrinol Lett. 2011; 32(6): 799–804.
5. Ford WCL. Comments on the release of the 5th edition of the WHO Laboratory Manual for the Examination and Processing of Human Semen. Asian J Androl. 2010; 12(1): 59–63.
6. Wise LA, Rothman KJ, Mikkelsen EM, Sørensen HT, Riis A, Hatch EE. An internet-based prospective study of body size and time-to-pregnancy. Hum Reprod. 2010; 25(1): 253–64.
7. Hajshafiha M, Ghareaghaji R, Salemi S, Sadegh-Asadi N, Sadeghi-Bazargani H. Association of body mass index with some fertility markers among male partners of infertile couples. Int J Gen Med. 2013; 6: 447–51.
8. Weeg N, Shalom-Paz E, Wiser A. Age and infertility: the clinical point of view. Minerva Ginecol. 2012; 64(6): 477–83.
9. Dunson DB, Baird DD, Colombo B. Increased infertility with age in men and women. Obstet Gynecol. 2004; 103(1): 51–6.
10. Taha EA, Ezz-Aldin AM, Sayed SK, Ghandour NM, Mostafa T. Smoking influence on sperm vitality, DNA fragmentation, reactive oxygen species and zinc in oligoasthenoteratozoospermic men with varicocele. Andrologia. 2013.
11. Anderson K, Nisenblat V, Norman R. Lifestyle factors in people seeking infertility treatment – A review. Aust N Z J Obstet Gynaecol. 2010; 50(1): 8–20.
12. Optimizing natural fertility: a committee opinion. Fertil Steril. 2013; 100(3): 631–7.
13. Chavarro JE, Rich-Edwards JW, Rosner BA, Willett WC. Caffeinated and alcoholic beverage intake in relation to ovulatory disorder infertility. Epidemiology. 2009; 20(3): 374–81.
14. Klonoff-Cohen H. Female and male lifestyle habits and IVF: what is known and unknown. Hum Reprod Update. 2005; 11(2): 179–203.
15. Mmbaga N, Luk J. The impact of preconceptual diet on the outcome of reproductive treatments. Curr Opin Obstet Gynecol. 2012; 24(3): 127–31.
16. Condorelli RA, Calogero AE, Vicari E, La Vignera S. Chronic consumption of alcohol and sperm parameters: our experience and the main evidences. Andrologia. 2014.
17. Klonoff-Cohen H, Lam-Kruglick P, Gonzalez C. Effects of maternal and paternal alcohol consumption on the success rates of in vitro fertilization and gamete intrafallopian transfer. Fertil Steril. 2003; 79(2): 330–9.
18. Bari M, Battista N, Pirazzi V, Maccarrone M. The manifold actions of endocannabinoids on female and male reproductive events. Front Biosci (Landmark Ed). 2011; 16: 498–516.
19. Alvarez S, Fallet C. [Role of toxic factors in the fecundity of the couple]. J Gynecol Obstet Biol Reprod (Paris). 2010; 39(1 Suppl): 39–40.
20. De Souza GL, Hallak J. Anabolic steroids and male infertility: a comprehensive review. BJU Int. 2011; 108(11): 1860–5.
21. Barazani Y, Katz BF, Nagler HM, Stember DS. Lifestyle, environment, and male reproductive health. Urol Clin North Am. 2014; 41(1): 55–66.
22. Bhongade MB, Prasad S, Jiloha RC, Ray PC, Mohapatra S, Koner BC. Effect of psychological stress on fertility hormones and seminal quality in male partners of infertile couples. Andrologia. 2014.
23. Coughlan C, Walters S, Ledger W, Li TC. A comparison of psychological stress among women with and without reproductive failure. Int J Gynaecol Obstet. 2014;124(2):143–7.
24. Jóźków P, Mędraś M. Psychological stress and the function of male gonads. Endokrynol Pol. 2012; 63(1): 44–9.
25. Hakim LZ, Newton CR, MacLean-Brine D, Feyles V. Evaluation of preparatory psychosocial counselling for medically assisted reproduction. Hum Reprod. 2012; 27(7): 2058–66.
26. Hashemi S, Simbar M, Ramezani-Tehrani F, Shams J, Majd HA. Anxiety and success of in vitro fertilization. Eur J Obstet Gynecol Reprod Biol. 2012; 164(1): 60–4.
27. Ramezanzadeh F, Noorbala A-A, Abedinia N, Rahimi Forooshani A, Naghizadeh MM. Psychiatric intervention improved pregnancy rates in infertile couples. Malays J Med Sci. 2011; 18(1): 16–24.
28. Bhasin S. Approach to the infertile man. J Clin Endocrinol Metab. 2007; 92(6): 1995–2004.
29. Imhof M, Lackner J, Lipovac M, Chedraui P, Riedl C. Improvement of sperm quality after micronutrient supplementation. ESPEN J. 2012; 7(1): e50–e53.
30. Sigman M, Glass S, Campagnone J, Pryor JL. Carnitine for the treatment of idiopathic asthenospermia: a randomized, double-blind, placebo-controlled trial. Fertil Steril. 2006; 85(5): 1409–14.
31. Balercia G, Regoli F, Armeni T, Koverech A, Mantero F, Boscaro M. Placebo-controlled double-blind randomized trial on the use of L-carnitine, L-acetylcarnitine, or combined L-carnitine and L-acetylcarnitine in men with idiopathic asthenozoospermia. Fertil Steril. 2005; 84(3): 662–71.
32. Balercia G, Mosca F, Mantero F, Boscaro M, Mancini A, Ricciardo-Lamonica G, Littarru G. Coenzyme Q(10) supplementation in infertile men with idiopathic asthenozoospermia: an open, uncontrolled pilot study. Fertil Steril. 2004; 81(1): 93–8.
33. Sheweita SA, Tilmisany AM, Al-Sawaf H. Mechanisms of male infertility: role of antioxidants. Curr Drug Metab. 2005; 6(5): 495–501.
34. Aksglaede L, Juul A. Testicular function and fertility in men with Klinefelter syndrome: a review. Eur J Endocrinol. 2013; 168(4): R67–76.
35. Tournaye H. Male factor infertility and ART. Asian J Androl. 2012; 14(1): 103–8.
36. King TFJ, Hayes FJ. Long-term outcome of idiopathic hypogonadotropic hypo go nadism. Curr Opin Endocrinol Diabetes Obes. 2012; 19(3): 204–10.
37. Silveira LFG, Latronico AC. Approach to the patient with hypogonado-tropic hypogonadism. J Clin Endocrinol Metab. 2013;9 8(5): 1781–8.
38. Anawalt BD. Approach to male infertility and induction of spermatogenesis. J Clin Endocrinol Metab. 2013; 98(9): 3532–42.
39. Szkodziak P, Plewka K, Woźniak S, Czuczwar P, Mroczkowski A. Modified semen processing technique in a retrograde ejaculation infertile patient for the purpose of intrauterine insemination – a case report. Hum Reprod. 2012; 27(suppl 2): 121–2.
40. Ohl DA, Quallich SA, Sønksen J, Brackett NL, Lynne CM. Anejaculation and retrograde ejaculation. Urol Clin North Am. 2008; 35(2): 211–20,VIII.
41. Kim ED, Crosnoe L, Bar-Chama N, Khera M, Lipshultz LI. The treatment of hypogonadism in men of reproductive age. Fertil Steril. 2013; 99(3): 718–24.
42. Coviello AD, Matsumoto AM, Bremner WJ, Herbst KL, Amory JK, Anawalt BD, Sutton PR, Wright WW, Brown TR, Yan X, Zirkin BR, Jarow JP. Low-dose human chorionic gonadotropin maintains intratesticular testosterone in normal men with testosterone-induced gonadotropin suppression. J Clin Endocrinol Metab. 2005; 90(5): 2595–602.
43. Han TS, Bouloux PMG. What is the optimal therapy for young males with hypogonadotropic hypogonadism? Clin Endocrinol (Oxf). 2010; 72(6): 731–7.
44. Palermo GD, Neri Q V, Takeuchi T, Rosenwaks Z. ICSI: where we have been and where we are going. Semin Reprod Med. 2009; 27(2): 191–201.
45. Harnisch B, Oates R. Genetic disorders related to male factor infertility and their adverse consequences. Semin Reprod Med. 2012; 30(2): 105–15.
46. Ebisch IMW, Thomas CMG, Peters WHM, Braat DDM, Steegers-Theunissen RPM. The importance of folate, zinc and antioxidants in the pathogenesis and prevention of subfertility. Hum Reprod Update. 2007; 13(2): 163–74.
47. Afeiche MC, Bridges ND, Williams PL, Gaskins AJ, Tanrikut C, Petrozza JC, Hauser R, Chavarro JE. Dairy intake and semen quality among men attending a fertility clinic. Fertil Steril. 2014; 101(5): 1280–1287.e2.
48. Raheem OA. Surgical management of adolescent varicocele: Systematic review of the world literature. Urol Ann. 2013; 5(3): 133–9.
49. Serefoglu EC, Saitz TR, La Nasa JA, Hellstrom WJ. Adolescent varicocoele management controversies. Andrology. 2013; 1(1): 109–15.
50. Cayan S, Shavakhabov S, Kadioğlu A. Treatment of palpable varicocele in infertile men: a meta-analysis to define the best technique. J Androl. 2009; 30(1): 33–40.