0.829
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20
MNiSW
166.26
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RESEARCH PAPER
 
 

Effect of pesticides on kynurenic acid production in rat brain slices.

Tomasz Kocki 2,  
Tomasz Saran 1,  
Damian Kuc 2,  
Ildiko Vilagi 3,  
Ewa M Urbańska 1, 2,  
 
1
Department of Toxicology, Institute of Agricultural Medicine, Lublin, Poland
2
Department of Pharmacology and Toxicology, Medical University, Lublin, Poland
3
Department of Physiology and Neurobiology, Eotvos Lorand University, Budapest, Hungary
Ann Agric Environ Med 2005;12(2):177–179
KEYWORDS:
ABSTRACT:
Kynurenic acid (KYNA) is a broad spectrum antagonist of ionotropic glutamate receptors, preferentially active at the strychnine-insensitive glycine allosteric site of the N-methyl-D-aspartate (NMDA) receptor, and a noncompetitive antagonist of alpha7 nicotinic receptor. Animal studies showed that it possesses anticonvulsant and neuroprotective properties. Its involvement in the pathophysiology of various brain disorders was suggested. In this study, the effect of pesticides on KYNA production in brain cortical slices was investigated. Pyrethroids, deltamethrin and fenpropathrin significantly lowered KYNA production. Methomyl, bensultap, fipronil, diquat and MCPA were ineffective in this regard. In view of this data, the inhibition of KYNA synthesis appear to merit further investigation as a potential factor contributing to the toxicology of pyrethroids.
eISSN:1898-2263
ISSN:1232-1966