Alcohol consumption and quality of embryos obtained in programmes of in vitro fertilization
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Diagnostic Techniques Unit, Faculty of Nursing and Health Sciences, Medical University, Lublin, Poland
Department of Obstetrics, Gynaecology and Obstetrical-Gynaecological Nursing Faculty of Nursing and Health Sciences, Medical University, Lublin, Poland
Department of Obstetrics, Gynaecology and Obstetrical-Gynaecological Nursing Faculty of Nursing and Health Sciences, Medical University, Lublin, Poland
Department for Health Problems of Ageing, Institute of Rural Health, Lublin, Poland
Ann Agric Environ Med. 2014;21(2):450–453
introduction. Infertility is defined as a state when a couple fails to conceive a pregnancy after one year of regular intercourse without the use of contraception. Alcohol consumption is one of the main stimulants which negatively affect the female and male reproductive system. objective. The objective of the study was analysis of the effect of alcohol consumption by the examined women on the quality of embryos obtained during in vitro fertilization programmes. material and methods. The study covered 54 women who received treatment due to infertility. The database and statistical analyses were performed using computer software STATISTICA 7.1 (StatSoft, Poland). results. The study showed that 42.59% from among 100% of the women in the study consumed alcohol. In the group of women who consumed alcohol, class A embryos constituted 4.35%, class B embryos – 86.96%, while embryos of class C – 8.69%. A statistically significant difference was observed between the classes of embryos and alcohol consumption by the women examined (p=0.001). In addition, a statistically significant relationship was found between the amount of alcohol consumed and the classes of embryos (p=0.005). A significantly larger number of class B embryos came from women who consumed more than 25 grams of ethyl alcohol daily (72.72%), compared to those who consumed alcohol sporadically (44.44%), or those who abstained entirely from alcohol (30.00%). conclusions. Alcohol consumption causes the development of poorer quality embryos. Significantly more embryos of class B came from oocytes of women who consumed alcohol, compared to class A. An active campaign against alcohol consumption should be carried out among women at reproductive age to safeguard their fertility and future motherhood.
Polskie Towarzystwo Ginekologiczne. Rekomendacje dotyczące diagnostyki i leczenia niepłodności- skrót. Ginekol Pol. 2012; 83: 149–154 (in Polish).
Mumtaz Z, Shahid U, Levay A. Understanding the impact of gendered roles on the experiences of infertility amongst men and women in Punjab. Reprod Health. 2013; 10: 3.
Wdowiak A, Lewicka M, Plewka K, Bakalczuk G. Nicotinism and quality of embryos obtained in in-vitro fertilization programmes. Ann Agric Environ Med. 2013; 20(1): 82–85.
Kot-Leibovich H, Fainsod A. Ethanol induces embryonic malformations by competing for retinaldehyde dehydrogenase activity during vertebrate gastrulation. Disease Models & Mechanisms. 2009; 2: 295–305.
Moskalewicz J. Problemy zdrowia prokreacyjnego związane z konsumpcją alkoholu.Alkohol Narkom. 2007; 20(1): 55–63 (in Polish).
Ornoy A, Ergaz Z. Alcohol abuse in pregnant women: effects on the fetus and newborn, mode of action and maternal treatment. Int. J. Environ. Res. Public Health. 2010; 7: 364–379.
Żuralska R, Kuzepska M, Mziray M, Postrożny D, Muczyn A, Studzińska B, Książek J. Alkohol i ciąża. Wstępne badanie opinii kobiet na temat spożycia alkoholu w okresie ciąży. Probl Pielęg. 2011; 19(4): 533–537 (in Polish).
Halder D, Park JH, Choi MR, Chai JC, Lee YS, Mandal C, Jung KH, Chai YG. Chronic ethanol exposure increases goosecoid (GSC) expression in human embryonic carcinoma cell differentiation. J Appl Toxicol. 2013: 1–7.
Zhou FC, Zhao Q, Liu Y, Goodlett CR, Liang T, McClintick JN, Edenberg HJ, Li L. Alteration at early neurulation. BMC Genomics. 2011; 12:124.
Wojtyła A, Kapka-Skrzypczak L, Diatczyk J, Fronczak A, Paprzycki P. Alcohol-related Developmental Origin of Adult Health- population studies in Poland among mothers and newborns (2010–2012). Ann Agric Environ Med. 2012; 19(3): 365–377.
Rokicki T. Dojrzewanie komórek jajowych w warunkach in vitro. Ginekol Dypl. 2008; 9(4): 23–27 (in Polish).
Rokicki T. Zachowanie płodności u kobiet. Ginekol Dypl. 2008; 10(3): 33–37 (in Polish).
Ouko LA, Shantikumar K, Knezovich J, Haycock P, Schnugh DJ, Ramsay M. Effect of alcohol consumption on CpG methylation in the differentially methylated regions of H19 and IG-DMR in male gametes- implications for fetal alcohol spectrum disorders. Alcohol Clin Exp Res. 2009; 33(9): 1615–1627.
Sioda T. Wpływ alkoholu na prokreację i wczesny okres macierzyństwa. Pediatr Pol. 2009; 84(4): 344–361 (in Polish).
Jensen TK, Hjollund NK, Henriksen TB, Scheike T, Kolstad H, Giwercman A i wsp. Does moderate alcohol consumption affect fertility? Follow up study among couples planing first pregnancy. BMJ 1998; 3: 505–510.
Eggert J, Theobald MB, Cramer DW. Effects of alcohol consumption on female fertility during an 18- year period. Fertil Steril. 2004; 81: 379–383.
Royal College of Obstetricians and Gynaecologists Statement. Wpływ alkoholu na przebieg ciąży. Med Prakt Ginekol Położ. 2007; 3 (in Polish).
Klonoff-Cohen H, Lam-Kruglick P, Gonzalez C. Effects of maternal and paternal alcohol consumption on the success rates of in vitro fertilization and gamete intrafallopian transfer. Fertil Steril. 2003; 79: 330–339.
Aronne MP, Guadagnoli T, Fontanek P, Evrard SG, Brusco A. Effects of prenatal etanol exposure on rat brain radial glia and neuroblast migration. Experiment Neurol. 2011; 229: 364–371.
Liu Y, Balaraman Y, Wang G, Nephew KP, Zhoun FC. Alcohol exposure alters DNA methylation profiles in mouse embroys at early nerulation. Epigenetics. 2009; 4(7): 500–511.
Mukhopadhyay P, Rezzoug F, Kaikus J, Greene RM, Pisano MM. Alcohol modulates expression of DNA methyltranferases and methyl CpG-/CpG domain- binding proteins in murine embryonic fibroblasts. Reproduct Toxicol. 2013; 1: 1–19.
Peng Y, Yang PH, Ng SSM, Wong OG, Liu J, He ML, Kung HF, Lin MCM. A critical role of PAx6 in alcohol-induced fetal microcephaly. Neurobiol Disease. 2004; 16: 370–376.
Tran TD, Kelly SJ. Critical periods for ethanol-induced cell loss in the hippocampal formation. Neurotoxicol Teratol. 3003; 25: 519–528.
Yelin R, Ben-Haroush S, Kot H, Sharon Z. Frumkin A, Pillemer G, Fainsod A. Ethanol exposure affects gene expression in the embryonic organizer and reduces retinoic acid levels. Develop Biol. 2005; 279: 193–204.