Ethanol as a stimulus to risky and auto-aggressive behaviour
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Medical University, Warsaw, Poland
Medical University, Lublin, Poland
Military University of Aviation, Dęblin, Poland
Corresponding author
Dorota Lasota   

Warszawski Uniwersytet Medyczny, Poland
Ann Agric Environ Med. 2021;28(2):220-223
According to the World Health Organization (WHO), ethyl alcohol occupies the third place among health risks for the general population, causing damage to health as well as social damage. Ethanol is also considered the greatest risk factor in injuries. Both alcohol and its main metabolite, acetaldehyde, are directly toxic to tissues and lead to several systemic pathologies. Alcohol abuse may also lead to mental health disorders. Although one-in-eight adult Poles abstains from drinking alkohol, 10–20% of adult Poles drink alcohol regularly. It is estimated that this group includes about 900,000 addicts, and over 2,000,000 people who drink alcohol at a risky or harmful level. It affects their occurrence and their consequences Drink- driving is one of the problems most often raised, although alcohol is a documented risk factor in pedestrian accidents. It is also an important risk factor for suicidal behaviour with people under the influence of alcohol choosing more radical and effective methods of committing suicide, such as hanging or ‘throwing themselves under a moving vehicle.’ Only properly selected and consistently taken preventive actions can improve the tragic statistics related to ethanol stimulating risky and auto-aggressive behaviours. It is also necessary to improve the system for reporting such events because only reliable statistics enable proper assessment of the scale of the problem, and the effectiveness of these activities.
Trias-Llimós S, Kunst AE, Jasilionis D, Janssen F. The contribution of alcohol to the East-West life expectancy gap in Europe from 1990 onward. Inter J Epidemiol. 2018; 47(3): 731–739.
Fortuna LR, Porche MV, Padilla A. A treatment development study of cognitive and mindfulness-based therapy for adolescents with co-occurring post-traumatic stress and substance use disorder. Psychology and Psychotherapy: Theory, Research and Practice. 2018; 91(1): 42–62.
Auerbach RP, et al. Mental disorders among college students in the World Health Organization world mental health surveys. Psychol Med. 2016; 46(14): 2955–2970.
Marx W, Moseley G, Berk M, Jacka F. Nutritional psychiatry: the present state of the evidence. Proceedings of the Nutrition Society. 2017; 76(4): 427–436.
Bell RL, et al. A genetic animal model of alcoholism for screening medications to treat addiction. Int Rev Neurobiol. 2016; 126: 179–261. Academic Press.
Lasota D, et al. The effect of ethyl alcohol on the severity of injuries in fatal pedestrian victims of traffic crashes. PLoS One. 2019; 14(9).
Lasota D, et al. Effects of ethyl alcohol on injuries severity according to injury severity scales in pedestrian fatal injury in traffic crashes. Int J Inj Contr Saf Promot. 2019; 1–9.
Gjerde H, Romeo G, Mørland J. Challenges and common weaknesses in case-control studies on drug use and road traffic injury based on drug testing of biological samples. Ann Epidemiol. 2018; 28(11): 812–820.
Watling CN, Armstrong KA, Smith SS, Wilson A. The on-road experiences and awareness of sleepiness in a sample of Australian highway drivers: A roadside driver sleepiness study. Traffic Inj Prev. 2016; 17(1): 24–30.
Burns E, Kakara R. Deaths from falls among persons aged≥ 65 years—United States, 2007–2016. MMWR Morb Mortal Wkly Rep. 2018; 67(18): 509.
Esser MB, et al. Characteristics associated with alcohol consumption among emergency department patients presenting with road traffic injuries in Hyderabad, India. Inj. 2016; 47(1): 160–165.
Koh DH, et al. Cancer incidence and mortality among temporary maintenance workers in a refinery/petrochemical complex in Korea. Int J Occup Environ Health. 2014; 20(2): 141–145.
Geulayov G, et al. Incidence of suicide, hospital-presenting non-fatal self-harm, and community-occurring non-fatal self-harm in adolescents in England (the iceberg model of self-harm): a retrospective study. The Lancet Psychiatry. 2018; 5(2): 167–174.
Wang J, et al. Postsynaptic RIM1 modulates synaptic function by facilitating membrane delivery of recycling NMDARs in hippocampal neurons. Nat Commun. 2018; 9(1): 1–15.
Newman EL, et al. A role for prefrontal cortical NMDA receptors in murine alcohol-heightened aggression. Neuropsychopharmacology. 2018; 43(6): 1224–1234.
Chastain LG, Sarkar DK. Role of microglia in regulation of ethanol neurotoxic action. Int Rev Neurobiol. 2014; 118: 81–103). Academic Press.
Gaddini GW, et al. Alcohol: a simple nutrient with complex actions on bone in the adult skeleton. Alcohol Clin Exp Res. 2016; 40(4): 657–671.
Pereira RB, Andrade PB, Valentao P. A comprehensive view of the neurotoxicity mechanisms of cocaine and ethanol. Neurotoxicity Res. 2015; 28(3): 253–267.
Natarajan SK, Pachunka JM, Mott JL. Role of microRNAs in alcohol-induced multi-organ injury. Biomolecules. 2015; 5(4): 3309–3338.
Li CY, et al. Metabolomic study on idiosyncratic liver injury induced by different extracts of Polygonum multiflorum in rats integrated with pattern recognition and enriched pathways analysis. Front Pharmacol. 2016; 7: 483.
González-Reimers E, et al. Effects of Alcohol on the Corpus Callosum. In: Neuroscience of Alcohol. Academic Press. 2019; 143–152.
Li Y, Autophagy in alcohol-induced multiorgan injury: mechanisms and potential therapeutic targets. BioMed research international. 2014.
Gyongyosi B, et al. Alcohol-induced IL-17A production in Paneth cells amplifies endoplasmic reticulum stress, apoptosis, and inflammasome-IL-18 activation in the proximal small intestine in mice. Mucosal Immunol. 2019; 12(4): 930–944.
French SW. Chronic alcohol binging injures the liver and other organs by reducing NAD+ levels required for sirtuin’s deacetylase activity. Exp Mol Pathol. 2016; 100(2): 303–306.
Cabarcos P, et al. Quantification of fatty acid ethyl esters (FAEE) and ethyl glucuronide (EtG) in meconium for detection of alcohol abuse during pregnancy: correlation study between both biomarkers. J Pharmaceutical Biomedical Analysis. 2014; 100: 74–78.
Wang Q, et al. The clinical phenotypes of autoimmune hepatitis: a comprehensive review. J autoimmun. 2016; 66: 98–107.
Saha B, Momen-Heravi F, Kodys K, Szabo G. MicroRNA cargo of extracellular vesicles from alcohol-exposed monocytes signals naive monocytes to differentiate into M2 macrophages. J Biolo Chem. 2016; 291(1): 149–159.
Nowak M, Papiernik M, Mikulska A, Czarkowska-Paczek B. Smoking, alcohol consumption, and illicit substances use among adolescents in Poland. Subst Abuse Treat Prev Policy. 2018; 13(1): 42.
Mierzecki A, Kłoda K, Guźmińsk B, Morżak-Bożedajek A, Chełstowski K. Alcohol Drinking Pattern Is Associated with Demographic Features of Primary Health Care Patients in Poland: A Cross-Sectional Study. Med Sci Monit: Int Med J Exp Clin Res. 2018; 24: 2083.
Papalimperi AH, Athanaselis SA, Mina AD, Papoutsis II, Spiliopoulou CA, Papadodima SA. Incidence of fatalities of road traffic accidents associated with alcohol consumption and the use of psychoactive drugs: A 7-year survey (2011–2017). Exp Ther Med. 2019; 18(3): 2299–2306.
Haghpanahan H, et al. An evaluation of the effects of lowering blood alcohol concentration limits for drivers on the rates of road traffic accidents and alcohol consumption: a natural experiment. The Lancet. 2019; 393(10169): 321–329.
Blais E, Maurice P. Toward improved evaluations of laws against drink-driving. The Lancet. 2019; 393(10169): 297–298.
Valen A, Bogstrand ST, Vindenes V, Frost J, Larsson M, Holtan A, Gjerde H. Driver-related risk factors of fatal road traffic crashes associated with alcohol or drug impairment. Accid Anal Prev. 2019; 131: 191–199.
World Health Organization. Global status report on alcohol and health 2018. World Health Organization 2019.
Asgarian FS, Namdari M, Soori H. Worldwide prevalence of alcohol in fatally injured motorcyclists: A meta-analysis. Traffic Inj Prev. 2019; 20(7): 685–689.
Rolison JJ, Regev S, Moutari S, Feeney A. What are the factors that contribute to road accidents? An assessment of law enforcement views, ordinary drivers’ opinions, and road accident records. Accid Anal Prev. 2018; 115: 11–24.
Jørgenrud B, Bogstrand ST, Furuhaugen H, Jamt RE, Vindenes V, Gjerde H. Association between speeding and use of alcohol and medicinal and illegal drugs and involvement in road traffic crashes among motor vehicle drivers. Traffic Inj Prev. 2018; 19(8): 779–785.
Pawłowski W, et al. The effect of ethyl alcohol upon pedestrian trauma sustained in traffic crashes. Int J Environ Res Public Health. 2019; 16(8): 1471.
Timmins MA, et al. Does state dissociation mediate the relation between alcohol intoxication and deliberate self-harm? Arch Suicide Res. 2019; 1–12.
Evans JR, et al. The impact of alcohol intoxication on witness suggestibility immediately and after a delay. Appl Cogn Psychol. 2019; 33(3): 358–369.
O’Brien J. States of Intoxication: The Place of Alcohol in Civilisation. Routledge 2018.
Johnson EG, Skromanis S, Bruno R, Mond J, Honan CA. Inhibiting automatic negative social responses in alcohol intoxication: interactions with theory of mind ability and level of task guidance. Psychopharmacol. 2018; 235(4): 1221–1232.
Rehm J, et al. Alcohol dependence and very high risk level of alcohol consumption: a life-threatening and debilitating disease. Addict Biol. 2018; 23(4): 961–968.
Baykova MA, Merinov AV. Influence of parental alcoholism on suicidal and personality-psychological characteristics of offspring. IP Pavlov Russian Med Biol Herald. 2018; 26(4): 547–558.
Bartoli F, et al. Testing the association of serum uric acid levels with behavioral and clinical characteristics in subjects with major affective disorders: A cross-sectional study. Psychiatry Res. 2018; 269: 118–123.
Keane S, Szigeti A, Fanning F, Clarke M. Are patterns of violence and aggression at presentation in patients with first-episode psychosis temporally stable? A comparison of 2 cohorts. Early Interv Psychiatry. 2019; 13(4): 888–894.
Balabanova V, et al. Nonsuicidal self-injury in mentally ill patients: a clinical case. Neurology, Neuropsychiatry, Psychosomatics. 2019; 11(3): 83–88.
Smith MM, et al. The perniciousness of perfectionism: A meta-analytic review of the perfectionism–suicide relationship. J Personality. 2018; 86(3): 522–542.
General Police Headquarters of Poland: Zamachy samobójcze od 2017 (Suicide attempts since 2017). Available online: http://www.statystyka.policja.... [retrieved: 21.11.2018]. (in Polish).
Caetano R, et al. Precipitating circumstances of suicide and alcohol intoxication among US ethnic groups. Alcoholism: Clin Exp Res. 2015; 39(8): 1510–1517.
Yuodelis-Flores C, Ries RK. Addiction and suicide: a review. Am J Addict. 2015; 24(2): 98–104.
Park CH, et al. Impact of acute alcohol consumption on lethality of suicide methods. Compr Psychiatry. 2017; 75: 27–34.
Lasota D, et al. Alcohol intoxication and suicide by hanging in Poland. Alcohol Alcohol. 2020.
Orellana J, Souza C, Souza M. Hidden suicides of the indigenous people of the Brazilian Amazon: gender, alcohol and familial clustering. Revista colombiana de psiquiatria. 2019; 48(3): 133–139.
Bagge C, et al. Alcohol use to facilitate a suicide attempt: an event-based examination. J Stud Alcohol Drugs. 2015; 76(3): 474–481.
Lasota D, et al. Seasonality of suicides among victims who are under the influence of alcohol. Int J Environ Res Public Health. 2019; 16(15): 2806.
Niskanen L, Partonen T, Auvinen A, Haukka J. Excess mortality in Finnish diabetic subjects due to alcohol, accidents and suicide: a nationwide study. Eur J Endocrinol. 2018; 179(5): 299–306.
Darnell D, Dunn, C, Atkins D, Ingraham L, Zatzick DA randomized evaluation of motivational interviewing training for mandated implementation of alcohol screening and brief intervention in trauma centers. J Subst Abuse Treat. 2016; 60: 36–44.
Nowacki G, Olejnik K, Zakrzewsk, B. Safety Status on Road Transport System in the European Union. In International Conference on Reliability and Statistics in Transportation and Communication. 2018; 457–467. Springer, Cham.
Central Statistical Office of Poland. Available online: [retrieved: 01.10.2019]. (in Polish).
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