Pantoea agglomerans: a mysterious bacterium of evil and good. Part III. Deleterious effects: infections of humans, animals and plants

Jacek Dutkiewicz 1  ,  
Marcin Golec 1,  
Department of Biological Health Hazards and Parasitology, Institute of Rural Health, Lublin, Poland
Department of Pneumonology, Oncology and Allergology, Medical University of Lublin, Lublin, Poland
Department of Medical Biology, Institute of Rural Health, Lublin, Poland
Ann Agric Environ Med 2016;23(2):197–205
Pantoea agglomerans, a bacterium associated with plants, is not an obligate infectious agent in humans. However, it could be a cause of opportunistic human infections, mostly by wound infection with plant material, or as a hospital-acquired infection, mostly in immunocompromised individuals. Wound infection with P. agglomerans usually follow piercing or laceration of skin with a plant thorn, wooden splinter or other plant material and subsequent inoculation of the plant-residing bacteria, mostly during performing of agricultural occupations and gardening, or children playing. Septic arthritis or synovitis appears as a common clinical outcome of exogenous infection with P. agglomerans, others include endophthalmitis, periostitis, endocarditis and osteomyelitis. Another major reason for clinical infection with P. agglomerans is exposure of hospitalized, often immunodeficient individuals to medical equipment or fluids contaminated with this bacterium. Epidemics of nosocomial septicemia with fatal cases have been described in several countries, both in adult and paediatric patients. In most cases, however, the clinical course of the hospital-acquired disease was mild and application of the proper antibiotic treatment led to full recovery. Compared to humans, there are only few reports on infectious diseases caused by Pantoea agglomerans in vertebrate animals. This species has been identified as a possible cause of equine abortion and placentitis and a haemorrhagic disease in dolphin fish (Coryphaena hippurus). P. agglomerans strains occur commonly, usually as symbionts, in insects and other arthropods. Pantoea agglomerans usually occurs in plants as an epi- or endophytic symbiont, often as mutualist. Nevertheless, this species has also also been identified as a cause of diseases in a range of cultivable plants, such as cotton, sweet onion, rice, maize, sorghum, bamboo, walnut, an ornamental plant called Chinese taro (Alocasia cucullata), and a grass called onion couch (Arrhenatherum elatius). Some plant-pathogenic strains of P. agglomerans are tumourigenic, inducing gall formation on table beet, an ornamental plant gypsophila (Gypsophila paniculata), wisteria, Douglas-fir and cranberry. Recently, a Pantoea species closely related to P. agglomerans has been identified as a cause of bacterial blight disease in the edible mushroom Pleurotus eryngii cultivated in China. The genetically governed determinants of plant pathogenicity in Pantoea agglomerans include such mechanisms as the hypersensitive response and pathogenicity (hrp) system, phytohormones, the quorum-sensing (QS) feedback system and type III secretion system (T3SS) injecting the effector proteins into the cytosol of a plant cell.
Jacek Dutkiewicz   
Department of Biological Health Hazards and Parasitology, Institute of Rural Health, Lublin, Poland
1. Pien FD, Martin WJ, Hermans PE, Washington JA. Clinical and bacteriologic observations on the proposed species Enterobacter agglomerans (the herbicola-lathyri bacteria). Mayo Clin Proc. 1972; 47: 739–745.
2. Jain S, Bohra I, Mahajan R, Jain S, Chugh TD. Pantoea agglomerans infection behaving like a tumor after plant thorn injury: an unusual presentation. Indian J Pathol Microbiol. 2012; 55(3): 386–388.
3. Mason GI, Bottone EJ, Podos SM. Traumatic endophthalmitis caused by an Erwinia species. Am J Ophthal. 1976; 82(5): 709–713.
4. Olenginski TP, Bush DC, Harrington TM. Plant thorn synovitis: an uncommon cause of monoarthritis. Semin Arthritis Rheum. 1991; 21(1): 40–46.
5. Duerinckx JF. Case report: subacute synovitis of the knee after a rose thorn injury: unusual clinical picture. Clin Orthop Relat Res. 2008; 466(12): 3138–3142.
6. Lee NE, Chung IY, Park JM. A case of Pantoea endophthalmitis. Korean J Ophthalmol. 2010; 24(5): 318–321.
7. Flatauer FE, Khan MA. Septic arthritis caused by Enterobacter agglomerans. Arch Intern Med. 1978; 138(5): 788.
8. Rosenfeld R, Spigelblatt L, Chicoine R, Laverdiere M. Thorn-induced periostitis associated with Enterobacter agglomerans infection. Can Med Assoc J. 1978; 119(8): 925–928.
9. Strömqvist B, Edlund E, Lidgren L. A case of blackthorn synovitis. Acta Orthop Scand. 1985; 56(4): 342–343.
10. De Champs C, Le Seaux S, Dubost JJ, Boisgard S, Sauvezie B, Sirot J. Isolation of Pantoea agglomerans in two cases of septic monoarthritis after plant thorn and wood sliver injuries. J Clin Microbiol. 2000; 38(1): 460–461.
11. Kratz A, Greenberg D, Barki Y, Cohen E, Lifshitz M. Pantoea agglomerans as a cause of septic arthritis after palm tree thorn injury; case report and literature review. Arch Dis Child. 2003; 88(6): 542–544.
12. Ulloa-Gutierrez R, Moya T, Avila-Aguero ML. Pantoea agglomerans and thorn-associated suppurative arthritis. Pediatr Infect Dis J. 2004; 23(7): 690.
13. Rave O, Assous MV, Hashkes PJ, Lebel E, Hadas-Halpern I, Megged O. Pantoea agglomerans foreign body-induced septic arthritis. Pediatr Infect Dis J. 2012; 31(12): 1311–1312.
14. Vaiman M, Abuita R, Lazarovich T, Lotan G. Pantoea agglomerans as an indicator of a foreign body of plant origin in cases of wound infection. J Wound Care. 2013; 22: 182–185.
15. Sudhalkar A, Majji AB, Chhablani J, Manderwad G. Pantoea agglomerans endophthalmitis: clinical features and outcomes. Retina. 2014; 34(8): 1702–1706.
16. Venincasa VD, Kuriyan AE, Flynn HW Jr, Sridhar J, Miller D. Endophthalmitis caused by Pantoea agglomerans: clinical features, antibiotic sensitivities, and outcomes. Clin Ophthalmol. 2015; 9: 1203–1207.
17. Zuberbuhler B, Carifi G, Leatherbarrow B. Acute dacryocystitis in a 2-year old child caused by pantoea. Orbit. 2012; 31(1): 13–14.
18. Manoharan G, Lalitha P, Jeganathan LP, Dsilva SS, Prajna NV. Pantoea ananatis as a cause of corneal infiltrate after rice husk injury. J Clin Microbiol. 2012; 50(6): 2163–2164.
19. Williams AJK, Scott RJD, Lightfoot NF. Erwinia herbicola as a cause of bacterial endocarditis. J Infect. 1986; 12: 71–73.
20. Vincent K, Szabo RM. Enterobacter agglomerans osteomyelitis of the hand from a rose thorn. A case report. Orthopedics. 1988; 11(3): 465–467.
21. Labianca L, Montanaro A, Turturro F, Calderaro C, Ferretti A. Osteomyelitis caused by Pantoea agglomerans in a closed fracture in a child. Orthopedics. 2013; 36(2):e252–256.
22. Laporte C, Demachy MC, Thevenin-Lemoine C. Tibial osteitis caused by Pantoea agglomerans after open grade IIIB tibial shaft fracture. Rev Chir Orthop Reparatrice Appar Mot. 2002; 88(6): 625–627 (in French).
23. Maki DG, Rhame FS, Mackel DC, Bennett JV. Nationwide epidemic of septicaemia caused by contaminated intravenous products. I. Epidemiologic and clinical features. Am J Med. 1976; 60: 471–485.
24. Matsaniotis NS, Syriopoulou VP, Theodoridou MC, Tzanetou KG, Mostrou GI. Enterobacter sepsis in infants and children due to contaminated intravenous fluids. Infect Control. 1984; 5(10): 471–477.
25. Van Rostenberghe H, Noraida R, Wan Pauzi WI, Habsah H, Zeehaida M, Rosliza AR, Fatimah I, Nik Sharimah NY, Maimunah H. The clinical picture of neonatal infection with Pantoea species. Jpn J Infect Dis. 2006; 59(2): 120–121.
26. Shubov A, Jagannathan P, Chin-Hong PV. Pantoea agglomerans pneumonia in a heart-lung transplant recipient: case report and a review of an emerging pathogen in immunocompromised hosts. Transpl Infect Dis. 2011; 13(5): 536–539.
27. Rasmussen SW, Koczulab B. Transfusion associated bacteremia and septic shock due to Erwinia herbicola. Scand J Infect Dis. 1992; 24(2): 241–243.
28. Boszczowski I, Nóbrega de Almeida Júnior J, Peixoto de Miranda EJ, Pinheiro Freire M, Guimarães T, Chaves CE, Cais DP, Strabelli TM, Risek CF, Soares RE, Rossi F, Costa SF, Levin AS. Nosocomial outbreak of Pantoea agglomerans bacteraemia associated with contaminated anticoagulant citrate dextrose solution: new name, old bug? J Hosp Infect. 2012; 80(3): 255–258.
29. Habsah H, Zeehaida M, Van Rostenberghe H, Noraida R, Wan Pauzi WI, Fatimah I, Rosliza AR, Nik Sharimah NY, Maimunah H. An outbreak of Pantoea spp. in a neonatal intensive care unit secondary to contaminated parenteral nutrition. J Hosp Infect. 2005; 61(3): 213–218.
30. Bicudo EL, Macedo VO, Carrara MA, Castro FF, Rage RI. Nosocomial outbreak of Pantoea agglomerans in a pediatric urgent care center. Braz J Infect Dis. 2007; 11(2): 281–284.
31. Cruz AT, Cazacu AC, Allen CH. Pantoea agglomerans, a plant pathogen causing human disease. J Clin Microbiol. 2007; 45(6): 1989–1992.
32. Kurşun O, Unal N, Cesur S, Altın N, Canbakan B, Argun C, Koldaş K, Sencan I. A case of ventilator-associated pneumonia due to Pantoea agglomerans. Mikrobiyol Bul. 2012; 46(2): 295–298 (in Turkish).
33. Izzo I, Lania D, Castro A, Lanzini F, Bella D, Pagani A, Colombini P. Seven cases of port-a-cath contamination caused by Pantoea agglomerans in the Oncological Service of Iseo Hospital, Brescia (Italy). Infez Med. 2014; 22(2): 152–155 (in Italian).
34. Hrabińska-Zachwieja J, Krukowski J, Tubek S, Zeljaś A. Bacterial endocarditis caused by Enterobacter agglomerans in a patient with mitral valve leaflet prolapse. Wiad Lek. 1989; 42(7): 453–455 (in Polish).
35. Bergman KA, Arends JP, Schölvinck EH. Pantoea agglomerans septicemia in three newborn infants. Pediatr Infect Dis J. 2007; 26(5): 453–454.
36. Aly NY, Salmeen HN, Lila RA, Nagaraja PA. Pantoea agglomerans bloodstream infection in preterm neonates. Med Princ Pract. 2008; 17(6): 500–503.
37. Habhab W, Blake PG. Pantoea peritonitis: not just a “thorny” problem. Perit Dial Int. 2008; 28(4): 430.
38. Cheng A, Liu C-Y, Tsai H-Y, Hsu M-S, Yang C-J, Huang Y-T, Liao C-H, Hsueh P-R. Bacteremia caused by Pantoea agglomerans at a medical center in Taiwan, 2000–201J Microbiol Immunol Infection. 2013; 46: 187–194.
39. Cicchetti R, Iacobini M, Midulla F, Papoff P, Mancuso M, Moretti C. Pantoea agglomerans sepsis after rotavirus gastroenteritis. Pediatr Infect Dis J. 2006; 25(3): 280–281.
40. Christakis GB, Perlorentzou SP, Aslanidou M, Savva L, Zarkadis IK. Bacteremia caused by Pantoea agglomerans and Enterococcus faecalis in a patient with colon cancer. J BUON. 2007; 12(2): 287–290.
41. Liberto MC, Matera G, Puccio R, Lo Russo T, Colosimo E, Focà E. Six cases of sepsis caused by Pantoea agglomerans in a teaching hospital. New Microbiol. 2009; 32(1): 119–123.
42. Wang J, Fraser JF. An Intracranial Petri Dish? Formation of Abscess in Prior Large Stroke After Decompressive Hemicraniectomy. World Neurosurg. 2015; 84(5): 1495.e5–9.
43. Hischebeth GT, Kohlhof H, Wimmer MD, Randau TM, Bekeredjian-Ding I, Gravius S. Detection of Pantoea agglomerans in hip prosthetic infection by sonication of the removed prosthesis: the first reported case. Technol Health Care. 2013; 21(6): 613–618.
44. Seok S, Jang YJ, Lee SW, Kim HC, Ha GY. A case of bilateral endogenous Pantoea agglomerans endophthalmitis with interstitial lung disease. Korean J Ophthalmol. 2010; 24(4): 249–51.
45. Kletke SN, Brissette AR, Gale J. Endogenous bacterial endophthalmitis caused by Pantoea species: a case report. Can J Ophthalmol. 2014; 49(1): e1–doi: 10.1016/j.jcjo.2013.09.004.
46. Flores Popoca EO, Garcıa MM, Figueroa SR, Medellın AM, Trujillo HS, Rojas HVS, Durán NR. Clinical study: Pantoea agglomerans in immunodeficient patients with different respiratory symptoms. Scien World J 2012; 2012:156827, doi: 10.1100/2012/156827.
47. Lim PS, Chen SL, Tsai CY, Pai MA. Pantoea peritonitis in a patient receiving chronic ambulatory peritoneal dialysis. Nephrology. 2006; 11(2): 97–99.
48. Magnette C, Tintillier M, Horlait G, Cuvelier C, Pochet JM. Severe peritonitis due to Pantoea agglomerans in a CCPD patient. Perit Dial Int. 2008; 28(2): 207–208.
49. Ferrantino M, Navaneethan SD, Sloand JA. Pantoea agglomerans: an unusual inciting agent in peritonitis. Perit Dial Int. 2008; 28(4): 428–430.
50. Borràs M, Roig J, Garcia M, Fernández E. Adverse effects of pantoea peritonitis on peritoneal transport. Perit Dial Int. 2009; 29(2): 234–235.
51. Kazancioglu R, Buyukaydin B, Iraz M, Alay M, Erkoc R. An unusual cause of peritonitis in peritoneal dialysis patients: Pantoea agglomerans. J Infect Dev Ctries. 2014; 8(7): 919–922.
52. Naha K, Ramamoorthi, Prabhu M. Spontaneous septicaemia with multi-organ dysfunction – a new face for Pantoe agglomerans? Asian Pacific J Trop Med. 2012; 5(1): 83–84.
53. García-Pardo G, Martí N, Vidal F, Richart C. Enterobacter agglomerans pneumonia outside of the hospital in a previously health patient. Enferm Infecc Microbiol Clin. 1999; 17(1): 48 (in Spanish).
54. Al-Damluji S, Dickinson CM, Beck A. Enterobacter agglomerans: a new cause of primary pneumonia. Thorax. 1982; 37(11): 865–866.
55. Dutkiewicz J, Mackiewicz B, Lemieszek MK, Golec M, Skórska C, Góra-Florek A, Milanowski J. Pantoea agglomerans: a mysterious bacterium of evil and good. Part II. Deleterious effects: Dust-borne endotoxins and allergens – focus on grain dust, other agricultural dusts and wood dust. Ann Agric Environ Med. 2016; 23(1): 110–133.
56. Porter P, Wray CC. Enterobacter agglomerans spondylodiscitis: a possible, unrecognized complication of tetracycline therapy. Spine. 2000; 25(10): 1287–1289.
57. Rodrigues AL, Lima IK, Koury A Jr, de Sousa RM, Meguins LC. Pantoea agglomerans liver abscess in a resident of Brazilian Amazonia. Trop Gastroenterol. 2009; 30(3): 154–155.
58. Fullerton DG, Lwin AA, Lal S. Pantoea agglomerans liver abscess presenting with a painful thigh. Eur J Gastroenterol Hepatol. 2007; 19(5): 433–435.
59. Gonçalves MO, Coutinho-Filho WP, Pimenta FP, Pereira GA, Pereira JA, Mattos-Guaraldi AL, Hirata R Jr. Periodontal disease as reservoir for multi-resistant and hydrolytic enterobacterial species. Lett Appl Microbiol. 2007; 44(5): 488–494.
60. Gibson JA, Eaves LE, O’Sullivan BM. Equine abortion associated with Enterobacter agglomerans. Equine Vet J. 1982; 14(2): 122–125.
61. Hong CB, Donahue JM, Giles RC, Jr, Petrites-Murphy MB, Poonacha KB, Roberts AW, Smith BJ, Tramontin RR, Tuttle PA, Swerczek TW. Etiology and pathology of equine placentitis. J Vet Diagn Invest. 1993; 5: 56–63.
62. Pomorski ZJH, Dutkiewicz J, Taszkun I, Woźniak M, Sitkowski W, Skórska C, Cholewa G. Studies on allergic conditioning of cattle pneumopathy, resulting from breathing in pneumoallergens comprised in organic dusts. Ann UMCS (Sectio DD). 1993; 48: 183–193 (in Polish).
63. Verdier-Metz I, Gagne G, Bornes S, Monsallier F, Veisseire P, Delbès-Paus C, Montel MC. Cow teat skin, a potential source of diverse microbial populations for cheese production. Appl Environ Microbiol. 2012; 78(2): 326–333.
64. Kisková J, Hrehová Z, Janiga M, Lukáň M, Haas M, Čuvalováa Z. Bacterial prevalence in the Dunnock (Prunella modularis) in sub-alpine habitats of the Western Carpathians, Slovak Republik. Ornis Fennica. 2012; 89: 34–43.
65. Hansen GH, Raa J, Olafsen JA. Isolation of Enterobacter agglomerans from dolphin fish, Coryphaena hippurus L. J Fish Dis. 1990; 13: 93–96.
66. Loch TP, Faisal M. Isolation of Pantoea agglomerans from brown trout (Salmo trutta) from Gilchrist Creek, Michigan, USA. Bull Europ Assoc Fish Pathol. 2007; 27(5): 200–204.
67. Carbajal-González MT, Fregeneda-Grandes JM, Suárez-Ramos S, Rodríguez Cadenas F, Aller-Gancedo JM. Bacterial skin flora variation and in vitro inhibitory activity against Saprolegnia parasitica in brown and rainbow trout. Dis Aquat Organ. 2011; 96(2): 125–135.
68. Walterson AM, Stavrinides J. Pantoea: insights into a highly versatile and diverse genus within the Enterobacteriaceae. FEMS Microbiol Rev. 2015; 39: 968–984.
69. Loncaric I, Heigl H, Licek E, Moosbeckhofer R, Busse H-J, Rosengarten R. Typing of Pantoea agglomerans isolated from colonies of honey bees (Apis mellifera) and culturability of selected strains from honey. Apidologie. 2009; 40: 40–54.
70. Lozo J, Berić T, Terzić-Vidojević A, Stanković S, Fira D, Stanisavljević L. Microbiota associated with pollen, bee bread, larvae and adults of solitary bee Osmia cornuta (Hymenoptera: Megachilidae). Bull Entomol Res. 2015; 105(4): 470–476.
71. Suen G, Scott JJ, Aylward FO, Adams SM, Tringe SG, Pinto-Toma´s AA, Foster CE, Pauly M, Weimer PJ, Barry KW, Goodwin LA, Bouffard P, Li11 L, Osterberger J, Harkins TT, Slater SC, Donohue TJ, Currie1 CR. An insect herbivore microbiome with high plant biomass-degrading capacity. PLoS Genet. 2010; 6(9): e100112 doi: 10.1371/journal.pgen.1001129.
72. Potrikus CJ, Breznak JA. Nitrogen-fixing Enterobacter agglomerans isolated from guts of wood-eating termites. Appl Environ Microbiol. 1977; 33(2): 392–399.
73. Medrano EG, Esquivel JF, Bell AA. Transmission of cotton seed and boll rotting bacteria by the southern green stink bug (Nezara viridula L.). J Appl Microbiol. 2007; 103(2): 436–444.
74. Wang S, Ghosh AK, Bongio N, Stebbings KA, Lampe DJ, Jacobs-Lorena M. Fighting malaria with engineered symbiotic bacteria from vector mosquitoes. Proc Natl Acad Sci U S A. 2012; 109(31): 12734–12739.
75. Dillon RJ, Vennard CT, Charnley AK. A note: gut bacteria produce components of a locust cohesion pheromone. J Appl Microbiol. 2002; 92(4): 759–763.
76. Dutkiewicz J. Studies on endotoxins of Erwinia herbicola and their biological activity. Zbl Bakt Hyg I Abt Orig A. 1976; 236: 487–508.
77. Vieira RHS, de Lima EA, Sousa DBR, dos Reis EF, Costa RG, Rodrigues DP. Vibrio spp. and Salmonella spp., presence and susceptibility in crabs Ucides cordatus. Rev Inst Med Trop S Paulo. 2004; 46(4): 179–182.
78. Kania G, Kłapeć T. Seasonal activity of millipedes (Diplopoda) – their economic and medical significance. Ann Agric Environ Med. 2012; 19(4): 646–650.
79. Nadarasah G, Stavrinides J. Quantitative evaluation of the host-colonizing capabilities of the enteric bacterium Pantoea using plant and insect hosts. Microbiology. 2014; 160: 602–615.
80. Medrano EG, Bell AA. Role of Pantoea agglomerans in opportunistic bacterial seed and boll rot of cotton (Gossypium hirsutum) grown in the field. J Appl Microbiol. 2007; 102(1): 134–143.
81. Dutta B, Barman AK, Srinivasan R, Avci U, Ullman DE, Langston DB, Gitaitis RD. Transmission of Pantoea ananatis and P. agglomerans, causal agents of center rot of onion (Allium cepa), by onion thrips (Thrips tabaci) through feces. Phytopathology. 2014; 104(8): 812–819.
82. Gvozdiak RI, Iakovleva LM. Pantoea agglomerans – pathogen of Elytrigia repens and Arrhenatherum elatius diseases. Mikrobiol Z. 2007; 69(1): 61–67 (in Russian).
83. Madhukar B. Khetmalas, Arya K. Bal, Lisa D. Noble, John A. Gow. Pantoea agglomerans is the etiological agent for black spot necrosis on beach peas. Can J Microbiol. 1996, 42(12): 1252–1257.
84. Romeiro RS, Macagnan D, Mendonça HL, Rodrigues Neto J. Bacterial spot of Chinese taro (Alocasia cucullata) in Brazil induced by Pantoea agglomerans. Plant Pathol. 2007; 56: 103 doi: 10.1111/j.1365–3059.2007.01631.
85. Nadha HK, Salwan R, Kasana RC, Anand M, Sood A. Identification and elimination of bacterial contamination during in vitro propagation of Guadua angustifolia Kunth. Pharmacogn Mag. 2012; 8(30): 93–97.
86. Yang KQ, Qu WW, Liu X, Liu HX, Hou LQ. First report of Pantoea agglomerans causing brown apical necrosis of walnut in China. Plant Dis. 2011; 95(6): 773.
87. Morales-Valenzuela G, Silva-Rojas HV, Ochoa-Martinez D, Valadez-Moctezuma E, Alarcon-Zuniga B, Zelaya-Molina LX, Cordova-Tellez L, Mendoza-Onofre L, Vaquera-Huerta H, Carballo-Carballo A, Farfan-Gomez A, Avila-Quezada G. First report of Pantoea agglomerans causing leaf blight and vascular wilt in maize and sorghum in Mexico. Plant Dis. 2007; 91(10): 1365.
88. Lee HB, Hong JP, Kim SB. First report of leaf blight caused by Pantoea agglomerans on rice in Korea. Plant Dis. 2010; 94(11): 1372.
89. Kim YC, Kim KC, Cho BH. Palea browning disease of rice caused by Erwinia herbicola and ice nucleation activity of the pathogenic bacteria. Korean J Plant Pathol. 1989; 5(1): 72–79.
90. Katsube K, Sato K, Shirakawa T, Takeda S. Occurrence of bacterial palea browning disease of rice in Iwate Prefecture. Annual Rep Soc Plant Protect North Japan. 1995; 46: 33–35.
91. Azegami K. Suppressive effect of bacteriophage on bacterial palea browning of rice caused by Pantoea ananatis. J Gen Plant Pathol. 2013; 79: 145–154.
92. Burr TJ, Katz BH, Abawi GS, Crosier DC. Comparison of tumorigenic strains of Erwinia herbicola isolated from table beet with E. h. gypsophilae. Plant Dis. 1991; 75: 855–858.
93. Manulis S, Barash I. Pantoea agglomerans pvs. gypsophilae and betae, recently evolved pathogens? Mol Plant Pathol. 2003; 4(5): 307–314.
94. Chalupowicz L(1), Manulis-Sasson S, Itkin M, Sacher A, Sessa G, Barash I. Quorum-sensing system affects gall development incited by Pantoea agglomerans pv. gypsophilae. Mol Plant Microbe Interact. 2008; 21(8): 1094–1105.
95. Barash I, Manulis-Sasson S. Recent evolution of bacterial pathogens: the gall-forming Pantoea agglomerans case. Annu Rev Phytopathol. 2009; 47: 133–152.
96. Chalupowicz L, Barash I, Panijel M, Sessa G, Manulis-Sasson S. Regulatory interactions between quorum-sensing, auxin, cytokinin, and the Hrp regulon in relation to gall formation and epiphytic fitness of Pantoea agglomerans pv. gypsophilae. Mol Plant Microbe Interact. 2009; 22(7): 849–856.
97. Panijel M, Chalupowicz L, Sessa G, Manulis-Sasson S, Barash I. Global regulatory networks control the hrp regulon of the gall-forming bacterium Pantoea agglomerans pv. gypsophilae. Mol Plant Microbe Interact. 2013; 26(9): 1031–1043.
98. Koutsoudis MD, Tsaltas D, Minogue TD, von Bodman SB. Quorum-sensing regulation governs bacterial adhesion, biofilm development, and host colonization in Pantoea stewartii subspecies stewartii. Proc Natl Acad Sci U S A. 2006; 103(15): 5983–5988.
99. Buonaurio R, Moretti C, da Silva DP, Cortese C, Ramos C, Venturi V. The olive knot disease as a model to study the role of interspecies bacterial communities in plant disease. Front Plant Sci. 2015; 6: 43 doi: 10.3389/fpls.2015.00434.
100. Ma Y, Yin Y, Rong C, Chen S, Liu Y, Wang S, Xu F. Pantoea pleuroti sp. nov., isolated from the fruiting bodies of Pleurotus eryngii. Curr Microbiol. 2016; 72(2): 207–212.
101. Lindow SE, Arny DC, Upper CD. Bacterial ice nucleation: a factor in frost injury to plants. Plant Physiol. 1982; 70(4): 1084–1089.
102. Phelps P, Giddings TH, Prochoda M, Fall R. Release of cell-free ice nuclei by Erwinia herbicola. J Bacteriol. 1986; 167(2): 496–502.
103. Li J, Lee TC. Enhanced production of extracellular ice nucleators from Erwinia herbicola. J Gen Appl Microbiol. 1998; 44(6): 405–413.
104. Dutkiewicz J, Tucker J, Burrell R, Olenchock SA, Schwegler-Berry D, Keller III GE, Ochalska B, Kaczmarski F, Skórska C. Ultrastructure of the endotoxin produced by Gram-negative bacteria associated with organic dusts. System Appl Microbiol. 1992; 15: 474–485.
105. Matsuzawa T, Mori K, Kadowaki T, Shimada M, Tashiro K, Kuhara S, Inagawa H, Soma G, Takegawa K. Genome sequence of Pantoea agglomerans strain IGJ Bacteriol. 2012; 194(5): 1258–1259.
106. Remus-Emsermann MN, Kim EB, Marco ML, Tecon R, Leveau JH. Draft genome sequence of the phyllosphere model bacterium Pantoea agglomerans 299R. Genome Announc. 2013; 1(1): e00036–1doi: 10.1128/genomeA.00036–13.
107. Smith DD, Kirzinger MW, Stavrinides J. Draft genome sequence of the antibiotic-producing cystic fibrosis isolate Pantoea agglomerans Tx1 Genome Announc. 2013; 1(5): e00904–1 doi: 10.1128/genomeA.00904–13.
108. Moretti C, Cortese C, Passos da Silva D, Venturi V, Torelli E, Firrao G, Buonaurio R. Draft genome sequence of a hypersensitive reaction-inducing Pantoea agglomerans strain isolated from olive knots caused by Pseudomonas savastanoi pv. savastanoi. Genome Announc. 2014; 2(4): e00774–1doi: 10.1128/genomeA.00774–14.
109. Minogue TD, Daligault HE, Davenport KW, Bishop-Lilly KA, Bruce DC, Chain PS, Coyne SR, Chertkov O, Freitas T, Frey KG, Jaissle J, Koroleva GI, Ladner JT, Palacios GF, Redden CL, Xu Y, Johnson SL. Draft genome assemblies of Enterobacter aerogenes CDC 6003–71, Enterobacter cloacae CDC 442–68, and Pantoea agglomerans UA 0804–0Genome Announc. 2014; 2(5): e01073–1doi: 10.1128/genomeA.01073–14.
110. Lim JA, Lee DH, Kim BY, Heu S. Draft genome sequence of Pantoea agglomerans R190, a producer of antibiotics against phytopathogens and foodborne pathogens. J Biotechnol. 2014; 188C: 7–doi: 10.1016/j.jbiotec.2014.07.440.
111. Smits THM, Rezzonico F, Blom J, Goesmann A, Abelli A, Kron Morelli R, Vanneste JL, Duffy B. Draft genome sequence of the commercial biocontrol strain Pantoea agglomerans P10c. Genome Announc. 2015; 3(6): e01448–1doi: 10.1128/genomeA.01448–15.
112. Rezzonico F, Stockwell VO, Tonolla M, Duffy B, Smits TH. Pantoea clinical isolates cannot be accurately assigned to species based on metabolic profiling. Transpl Infect Dis. 2012; 14(2): 220–221.
113. Delétoile A, Decré D, Courant S, Passet V, Audo J, Grimont P, Arlet G, Brisse S. Phylogeny and identification of Pantoea species and typing of Pantoea agglomerans strains by multilocus gene sequencing. J Clin Microbiol. 2009; 47(2): 300–310.
114. Völksch B, Thon S, Jacobsen ID, Gube M. Polyphasic study of plant- and clinic-associated Pantoea agglomerans strains reveals indistinguishable virulence potential. Infect Genet Evol. 2009; 9(6): 1381–1391.
115. De Maayer P, Chan WY, Blom J, Venter SN, Duffy B, Smits TH, Coutinho TA. The large universal Pantoea plasmid LPP-1 plays a major role in biological and ecological diversification. BMC Genomics. 2012; 13: 62doi: 10.1186/1471–2164–13–625.
116. Nissan G, Manulis-Sasson S, Weinthal D, Mor H, Sessa G, Barash I. The type III effectors HsvG and HsvB of gall-forming Pantoea agglomerans determine host specificity and function as transcriptional activators. Mol Microbiol. 2006; 61(5): 1118–1131.
117. Kirzinger MWB, Stavrinides J. Host specificity determinants as a genetic continuum. Trends Microbiol. 2012; 20(2): 88–93.
118. Correa VR, Majerczak DR, Ammar el-D, Merighi M, Pratt RC, Hogenhout SA, Coplin DL, Redinbaugh MG. The bacterium Pantoea stewartii uses two different type III secretion systems to colonize its plant host and insect vector. Appl Environ Microbiol. 2012; 78(17): 6327–6336.
119. Kirzinger MWB, Butz CJ, Stavrinides J. Inheritance of Pantoea type III secretion systems through both vertical and horizontal transfer. Mol Genet Genomics. 2015; 290(6): 2075–2088.
120. Dutkiewicz J, Mackiewicz B, Lemieszek M, Golec M, Milanowski J. Pantoea agglomerans: a mysterious bacterium of evil and good. Part I. Deleterious effects: Dust-borne endotoxins and allergens – focus on cotton dust. Ann Agric Environ Med. 2015; Ann Agric Environ Med. 2015, 22(4): 576–588.