The interaction between menstrual cycle, Tumour Necrosis Factor alpha receptors and sex hormones in healthy non-obese women – results from an observational study
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Department of Mother’s and Child’s Health, University of Medical Sciences, Poznań, Poland
Department of Educational Medicine, University of Medical Sciences, Poznań, Poland; Higher Vocational State School, Kalisz, Poland
Department of Health Informatics and Statistics, Institute of Rural Health, Lublin, Poland
Faculty of Pedagogy and Psychology, University of Economics and Innovation, Lublin, Poland
Corresponding author
Anna Włoszczak-Szubzda   

Department of Health Informatics and Statistics, Institute of Rural Health, Lublin, Poland
Ann Agric Environ Med. 2014;21(3):571-575
There is growing evidence that TNF-alpha and its two receptors play an important role in hormonal regulation, metabolism, inflammation and cancer. The biological effects of TNF-alpha are mediated by two receptors, p55 and p75. The aim of this study was to analyze serum concentrations of p55 and p75 and hormonal status in healthy women during the normal menstrual cycle. Eight women aged 20–22 with regular menstrual cycles were scheduled for examination on 3rd, 8th, 14th and 25th day of their menstrual cycle. We only observed a positive correlation of p75 subunit with prolactin level (correlation coefficient 0.417; p=0.0116) and negative correlation with insulin level (correlation coefficient -0.35; p=0.032) and HOMAIR insulin resistance index correlation coefficient 0.39; p=0.0185). Furthermore, a negative correlation of p55/p75 ratio with prolactin (correlation coefficient -0.42; p=0.0101) and a positive correlations of p55/p75 ratio with insulin level (correlation coefficient 0.43; p=0.008) and HOMAIR insulin resistance factor correlation coefficient 0.45; p=0.0065) were found.
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