RESEARCH PAPER
Prostate cancer in patients from rural and suburban areas – PSA value, Gleason score and presence of metastases in bone scan
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1
Hygiene and Diet Department, Jagiellonian University Medical College, Cracow, Poland
 
2
Nuclear Medicine Department, John Paul II Hospital, Cracow, Poland
 
3
Cardiovascular Diseases Department, Jagiellonian University Medical College, Cracow, Poland
 
4
Higher School of Public Health, Zielona Góra, Poland
 
5
Department for Health Problems of Ageing, Institute of Rural Health, Lublin, Poland
 
 
Corresponding author
Iwona Bojar   

Department for Health Problems of Ageing, Institute of Rural Health, Lublin, Poland
 
 
Ann Agric Environ Med. 2014;21(4):888-892
 
KEYWORDS
ABSTRACT
Introduction:
Prostate cancer is the second most common neoplasm among men both worldwide and in Poland. In prostate cancer, bone metastasis is related to a poorer prognosis. A diagnosis of metastatic bone disease is important in prostate cancer patients prior to therapy. Prostate specific antigen (PSA) serum value is used both as a screening tool and for staging of prostate cancer.

Aim:
To evaluate whether there is a link between symptoms presented by patients, pain in particular, and the presence, number and location of bone metastases as assessed by bone scan scintigraphy in concordance with PSA values and Gleason scores.

Material and Methods:
A group of 186 patients (aged: 68.38±6.16) diagnosed with prostate cancer, from rural and suburban areas of Małopolska province, that was directed for bone scan scintigraphy to the Nuclear Medicine Dept, John Paul II Hospital in Kraków. Analysis of all laboratory findings (including PSA value) and a biopsy were performed. Then, bone scan scintigraphy was done with the use of methylene disphosphonate (MDP) labeled with Tc-99m.

Results:
In patients with a Gleason value ≤7 and a PSA value ≤20 ng/ml, the cutoff value for a negative bone scan with a confidence interval of 0.95 was established at a PSA value below 10 ng/ml (p<0.01). Correlations were established between PSA value and presence of metastases in bone scan (r=0.45, p=0.05), the number of metastases (r=0.66, p<0.01), and their presence in particular body regions.

Conclusions:
The correlation between PSA value and both presence and number of metastases confirms the usefulness of bone scan scintigraphy in prostate cancer staging. The cutoff value for negative bone scan with a 95% confidence interval was established at PSA = 10 ng/ml.

 
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ISSN:1232-1966
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