Pre- and postnatal exposure of children to tobacco smoke during the first four years of life – observations of the authors
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2nd Department of Pediatrics and Allergology, Polish Mother’s Memorial Hospital - Research Institute, Lodz, Poland
Institute of General and Ecological Chemistry Technical University of Lodz, Poland
Department of Operative Gyneacology, Polish Mother’s Memorial Hospital - Research Institute, Lodz, Poland.
Corresponding author
Barbara Kamer   

2nd Department of Pediatrics and Allergology, Polish Mother’s Memorial Hospital - Research Institute, Lodz, Poland
Ann Agric Environ Med. 2014;21(4):753-759
Environmental exposure to tobacco smoke is a significant threat for human health, where the higher is its degree, the more immature the human organism is. Therefore, the exposure to Tobacco smoke in foetal life exerts unfavourable effects on developing foetus and may cause early and distant results in children.

Material and Methods:
The study comprised 318 children in their first four years of life, treated for various medical conditions. The examined children were divided into two groups, Group 1 – children exposed to Tobacco smoke – and Group 2 – a control group with children from non-smoking families. History data were obtained on the basis of a specially designed questionnaire, used by the doctor in an individual conversation with parent. In each third child from the group 1 cotinine concentration in urine was assayed by the method of high performance liquid chromatography-UV-VIS and the cotinine/creatinine ratio was calculated.

Results of study:
Results demonstrated environmental exposure to tobacco smoke in 173 children (Group 1). Out of them 31.2% were the children whose mothers had smoked also during pregnancy (Subgroup A). The other 119 children from Group 1 were accounted to Subgroup B, i.e., children, where other household members had been smoking cigarettes. A comparative group comprised 143 children from non-smoking families. The results demonstrated then that 17% of all the examined children were those, exposed to tobacco smoke effects already in their foetal life, predisposing them to prematurity and low birth weight. Moreover, it was observed that the young age and lower education level of their parents, together with worse housing conditions, may suggest a predisposing character and role of the mentioned factors.

Tutka P, Wielosz M, Zatoński W. Exposure to environmental tobacco smoke and children health. Int J Occup Med Environ Health. 2002; 15(4): 325–335.
Bartecchi CE, MacKenzie TD, Schrier RW. The human costs of tobacco use. N Engl. J Med.1994: 330(13): 907–912.
Florek E, Piekoszewski W. Ocena narażenia płodu, noworodka i dziecka na dym tytoniowy. Ginekol Praktyczna. 2002; 10: 10 (in Polish).
Sabanty W, Bróźik H. Selected parameters of health condition and the concentration of cotinine in urine in children from primary schools in Lodz expose to tobacco smoke in their home environment. Przegl Pediatr. 2004; 34: 52–59.
Flom JD, Ferris JS, Liao Y, Tehranifar P, Richards CB, Cho YH, et al. Prenatal smoke exposure and genomic DNA methylation in multiethnic birth cohort. Cancer Epidemiol Biomarkers Prev. 2011; 20(12): 2518– 2523.
Lemola S, Grob A. Drinking and smoking in pregnancy: what questions do Swiss physicians ask? Swiss Med Wkly. 2007; 137(3–4): 66–69.
Russel T, Crawford M, Woodby L. Measurements for active cigarette smoke exposure in prevalence and cessation studies: why simply asking pregnant women isn’t enough. Nicotine Tob. Res. 2004; Suppl 2: 141–151.
Ferreira-Borges C. Effectiveness of a brief counseling and behavioral intervention for smoking cessation in pregnant women. Prev Med. 2005; 41(1): 295–302.
Kalinka J. Ocena roli wybranych środowiskowych czynników ryzyka ograniczonego wzrostu płodu oraz porodu przedwczesnego przy zastosowaniu wskaźników biologicznych i biomarkerów ekspozycji. Rozprawa habilitacyjna. Folia Medica Lodziensia. 2006; 33(S1): 5–151 (in Polish).
Florek E, Piekoszewski W, Rybakowski Ł, Wrzosek J. Application of cotinine determination for the assessment of active and passive smoking of delivering women. Rocz Panstw Zakl Hig. 2003; 54: 34–36.
Czerwionka-Szaflarska M, Brazowski J, Romańczuk B, Śliwka K, Pufal E, Sykutera M. Analysis of cotinine concentration in the urine of infants and small children with lower respiratory tract inflammation in correlation with selected social conditions. Pol J Environ Stud. 2008; 17(4A): 99–104.
Zatoński W. Democracy and health: tobacco control in Poland. In: de Beyer, J., Brigden, W.(Eds.), Tobacco control policy, strategies, successes, and setbacks. World Bankand TITC, Washington 2003.p.97–120.
Vardavas CI, Plada M, Tzatzarakis M, Marcos A, Warnberg J, GomezMartinez S, et al. Passive smoking alters naïve/memory Lymphocyte T-cell subpopulations in children. Pediatr Allergy and Immunol. 2010; 21(8): 1171–1178.
Łasecka A, Czerwionka-Szaflarska M, Swincow G, Pufal E, BlockBogusławska E. The evaluation of tobacco smoke exposure in breastfeeding infants. Pediatria Polska. 2011; 86(1): 41–48.
Milidou I, Henriksen TB, Jensen MS, Olsen J, Sondergaard C. Nicotine replacement therapy during pregnancy and infantile colic in the offspring. Pediatrics. 2012; 129(3): 652–658.
Claude JA, Grimm A, Savage HP, Pinkerton KE. Perinatal exposure to environmental tobacco smoke (ETS) enhance susceptibility to viral and secondary bacterial infections. Int J Environ Res Public Health. 2012; 31;9(11): 3954–3964.
Guerrero-Preston R, Goldman LR, Brebi-Mieville P, Ili-Gangas C, Lebron C, Witter FR, et al. Global DNA hypomethylation is associated with in utero exposure to cotinine and perfluorinated alkyl compounds. Epigenetics. 2010; 16;5(6) 539–546.
Hwang SH, Hwang JH, Moon JS, Lee DH. Environmental tobacco smoke and children’s health. Korean J Pediatr. 2012; 55(2): 35–41.
Woźniacka A, Woźniacka-Węgierska M, Józefowicz O, SysaJędrzejowska A. Medical and legal aspects of smoking. Pol Merkur Lekarski. 2012; 32(189): 202–207.
Fust G, Arason GJ, Kramer J, Szalai C, Duba J, Yang Y, et al. Genetic basis of tobacco smoking: strong association of a specific major histocompatibillity complex haplotype on chromosome 6 with smoking behavior. Int Immunol. 2004; 16(10): 1507–1514.
Simpson WJ. A preliminary report on cigarette smoking and the incidence of prematurity. Am J Obstet Gynecol. 1957; 73(4): 808–815.
Coleman T. Special groups of smokers. BMJ 2004; 328: 575–577.
Falcon M, Vinas P, Perez-Carceles MD, Luna A. Placental cadmium and lipid peroxidation in smoking women related to newborn anthropometric measurements. Arch Environ Contam Toxicol. 2003; 45(2): 278–282.
Hackshaw A, Rodeck C, Boniface S. Maternal smoking in pregnancy and birth defects: a systematic review based on 173 687 malformed cases and 11,7 million controls. Hum Reprod Update. 2011; 17(5): 589–604.
Nishijo M, Nakagawa H, Honda R, Tanebe K, Saito K, Saito S, Teranishi H. Effects of maternal exposure to cadmium on pregnancy outcome and breast milk. Occup Environ Med. 2002; 59(6): 394–397.
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