Introduction and objective:
Peripheral nerve injuries are often a traumatic event that requires long-term rehabilitation-based treatment to regain the best possible mobility. One of the promising approaches to enhance recovery involves the use of locomotor training, which may influence neuroplasticity and functional regeneration. The aim of the study is to investigate the effect of forced treadmill training on locomotor functional recovery following sciatic nerve crush in Bcl-2 deficient mice. It is based on an evaluation of the results of a locomotor analysis of mice with an injured sciatic nerve, taking into account specific gait parameters using the Noldus CatWalk device.

Material and methods:
The animals trained on the treadmill for 30 minutes a day,5 days a week for 4 weeks after a crush injury of the sciatic nerve, at a speed (20 m / min), without rest, at 0 degrees and 30 degrees. The present research indicates that the bcl 2 gene plays an important role in regulating neuronal loss following axon injury. Particular attention is drawn to the fact that the functional recovery of mice lacking this gene is weaker than that of wild-type mice.

Results:
The differences observed in the recovery time of function in individual parameters of the treadmill alignment also reflect the dynamic changes taking place in the regenerating nerve. Mice lacking the bcl-2 gene regain their lost functions less clearly.

Conclusions:
Introduction and Objective. Peripheral nerve injuries are often a traumatic event that requires long-term rehabilitation- based treatment to regain the best possible mobility. One of the promising approaches to enhance recovery involves the use of locomotor training, which may influence neuroplasticity and functional regeneration. The aim of the study is to investigate the effect of forced treadmill training on locomotor functional recovery following sciatic nerve crush in Bcl-2 deficient mice. It is based on an evaluation of the results of a locomotor analysis of mice with an injured sciatic nerve, taking into account specific gait parameters using the Noldus CatWalk device. Materials and Method. The animals trained on the treadmill for 30 minutes a day,5 days a week for 4 weeks after a crush injury of the sciatic nerve, at a speed (20 m / min), without rest, at 0 degrees and 30 degrees. The present research indicates that the bcl 2 gene plays an important role in regulating neuronal loss following axon injury. Particular attention is drawn to the fact that the functional recovery of mice lacking this gene is weaker than that of wild-type mice. Results. The differences observed in the recovery time of function in individual parameters of the treadmill alignment also reflect the dynamic changes taking place in the regenerating nerve. Mice lacking the bcl-2 gene regain their lost functions less clearly. It is worth emphasizing the necessity to use intensified training. The rapid functional recovery in wild-type mice training at different levels thus demonstrates the importance of the presence of the bcl-2 gene, which clearly plays a decisive role here.t is worth emphasizing the necessity to use intensified training. The rapid functional recovery in wild-type mice training at different levels thus demonstrates the importance of the presence of the bcl-2 gene, which clearly plays a decisive role here.