REVIEW PAPER
Influence of pesticides on respiratory pathology – a literature review
| 1 | Department of Internal Medicine, ‘Iuliu Hatieganu’ University of Medicine and Pharmacy Cluj-Napoca, Cluj-Napoca, Romania |
| 2 | Department of Pneumology, ‘ Iuliu Hatieganu’ University of Medicine and Pharmacy Cluj-Napoca, Cluj-Napoca, Romania |
CORRESPONDING AUTHOR
Teodora Gabriela Alexescu
“Iuliu Hatieganu” University of Medicine and Pharmacy Cluj-Napoca, Department of Internal Medicine, Cluj-Napoca, Romania, Republicii no 18, 4000015, Cluj-Napoca, Romania
“Iuliu Hatieganu” University of Medicine and Pharmacy Cluj-Napoca, Department of Internal Medicine, Cluj-Napoca, Romania, Republicii no 18, 4000015, Cluj-Napoca, Romania
Ann Agric Environ Med. 2020;27(2):194–200
KEYWORDS
TOPICS
ABSTRACT
Introduction:
Pesticides are widely employed in agriculture, and the food industry is forced to combat the pests and diseases they cause. Respiratory pathology is related to occupational exposure to pesticides. Impairment of pulmonary function was observed among people professionally exposed to pesticides. Because of the marked use of pesticides in agriculture during the last 20 years, there has been a significant increase in respiratory problems within the population, not only among people who come in direct contact with them, but even in the case of manipulators.
Objective:
The aim is a review of the literature of the past 10 years on the correlation between occupational exposure to pesticides and respiratory pathology.
Material and Methods:
Electronic search in ‘Pub Med’ and ‘Web of Science’ was performed in September 2019 to find papers regarding the above-investigated aspects. Abstracts and full-text articles containing the targeted subject were included. Reviews and studies about the influence of pesticides on other pathologies than respiratory were excluded. After applying the inclusion and exclusion criteria, eligible full-text articles were identified.
Conclusions:
Exposure to pesticides is highly correlated with respiratory pathologies (asthma, COPD, lung cancer). Contact with these substances can occur at any time in the production, transport, preparation or application of the treatments. Numerous studies documented the association between exposure to pesticides, and therefore the increased incidence of respiratory, cardiovascular and renal diseases, as well as the aging phenomenon.
Pesticides are widely employed in agriculture, and the food industry is forced to combat the pests and diseases they cause. Respiratory pathology is related to occupational exposure to pesticides. Impairment of pulmonary function was observed among people professionally exposed to pesticides. Because of the marked use of pesticides in agriculture during the last 20 years, there has been a significant increase in respiratory problems within the population, not only among people who come in direct contact with them, but even in the case of manipulators.
Objective:
The aim is a review of the literature of the past 10 years on the correlation between occupational exposure to pesticides and respiratory pathology.
Material and Methods:
Electronic search in ‘Pub Med’ and ‘Web of Science’ was performed in September 2019 to find papers regarding the above-investigated aspects. Abstracts and full-text articles containing the targeted subject were included. Reviews and studies about the influence of pesticides on other pathologies than respiratory were excluded. After applying the inclusion and exclusion criteria, eligible full-text articles were identified.
Conclusions:
Exposure to pesticides is highly correlated with respiratory pathologies (asthma, COPD, lung cancer). Contact with these substances can occur at any time in the production, transport, preparation or application of the treatments. Numerous studies documented the association between exposure to pesticides, and therefore the increased incidence of respiratory, cardiovascular and renal diseases, as well as the aging phenomenon.
REFERENCES (47)
1.
Banu E. Prevenirea intoxicatiilor cu pesticide in activitatile din agricultura. Ministerul Muncii, Solidaritatii Sociale si Familiei, Inspectia Muncii. www.itmvaslui.ro/prevenirea%20intoxicatiilor%20cu%20pesticide.doc (access:2020.02.20).
2.
WHO. The who recommended classification of pesticides by hazard and guidelines to classification 2009. https://conspecte.com/Agricult... (access: 2020.02.20).
3.
Poisons Control, Department of Health and Community Services. Guidelines for the safe use of pesticides in non-agricultural workplaces. https://ww2.health.wa.gov.au/~... (accessed: 2019.06.24).
4.
Havrila (Lovasz) M E. Particularitati ale utilizarii si expunerii la pesticide in mediul rural.file:///C:/Users/simin/Downloads/Dana%20MOLDOVAN_rezumatteza_de_doctorat_rolovaszmariaelisabeta_2014-06-19_13_15_51.pdf (access:2019.06.20).
5.
Mamane A, Baldi I, Tessier JF, Raherison C, Bouvier G. Occupational exposure to pesticides and respiratory health. Eur Respir Rev. 2015; 24(136): 306–19.
6.
Ye M, Beach J, Martin JW, Senthilselvan A. Pesticide exposures and respiratory health in general population. J Environ Sci (China). 2017; 51: 361–370.
7.
Hernández AF, Parrón T, Alarcón R. Pesticides and asthma. Curr Opin Allergy Clin Immunol. 2011; 11: 90–96. doi: 10.1097/ACI.0b013e3283445939.
8.
Nicolopoulou-Stamati P, Maipas S, Kotampasi C, Stamatis P, Hens L. Chemical Pesticides and Human Health: The Urgent Need for a New Concept in Agriculture. Front Public Health. 2016; 4: 148.
9.
Henneberger PK, Liang X, London SJ, Umbach DM, Sandler DP, Hoppin JA. Exacerbation of symptoms in agricultural pesticide applicators with asthma. Int Arch Occup Environ Health. 2014; 87(4): 423–32.
10.
Li D, Huang Q, Lu M, Zhang L, Yang Z, Zong M, Tao L. The organophosphate insecticide chlorpyrifos confers its genotoxic effects by inducing DNA damage and cell apoptosis. Chemosphere. 2015; 135: 387–93.
11.
Shaffo FC, Grodzki AC, Fryer AD, Lein PJ. Mechanisms of organo -phosphorus pesticide toxicity in the context of airway hyperreactivity and asthma. Am J Physiol Lung Cell Mol Physiol. 2018 Oct 1; 315(4): L485-L501, doi: 10.1152/ajplung.00211.2018.
12.
Karami-Mohajeri S, Abdollahi M. Toxic influence of organophosphate, carbamate, and organochlorine pesticides on cellular metabolism of lipids, proteins, and carbohydrates: a systematic review. Hum Exp Toxicol. 2011; 30(9): 1119–40.
13.
Santus P, Corsico A, Solidoro P, Braido F, Di Marco F, Scichilone N. Oxidative Stress and Respiratory System: Pharmacological and Clinical Reappraisal of N-Acetylcysteine. COPD. 2014; 11(6): 705–717.
14.
Ohayo-Mitoko GJA, Kromhout H, Simwa JM, Boleij JSM, Heederik D. Self reported symptoms and inhibition of acetylcholinesterase activity among Kenyan agricultural workers. Occup Environ Med. 2000; 57: 195–200.
15.
Ye M, Beach J, Martin JW, Senthilselvan A. Occupational pesticide exposures and respiratory healt. Int J Environ Res Public Health. 2013; 10(12): 6442–71.
16.
Barczyk A, Sozańska E, Pierzchała W. The influence of occupational exposure to pesticides on the frequency of chronic obstructive pulmonary diseases. Wiad Lek. 2006; 59: 596–600.
17.
Rinsky JL, Richardson DB, Kreiss K, Nylander-French L, Beane Freeman LE, London SJ, Henneberger PK, Hoppin JA. Animal production, insecticide use and self-reported symptoms and diagnoses of COPD, including chronic bronchitis, in the Agricultural Health Study. Environ Int. 2019; 127: 764–772. https://doi.org/10.1016/j.envi....
18.
Hoppin JA, Valcin M, Henneberger PK, Kullman GJ, Umbach DM, London SJ, et al. Pesticide use and chronic bronchitis among farmers in the agricultural health study. Amer J Ind Med. 2007; 50: 969–979.
19.
Pesatori AC, Sontag JM, Lubin JH, Consonni D, Blair A. Cohort mortality and nested case-control study of lung cancer among structural pest control workers in Florida (United States). Cancer Cause Control. 1994; 5: 310–318.
20.
Lee WJ, Blair A, Hoppin JA, Lubin JH, Rusiecki JA, Sandler DP, Dosemeci M, Alavanja Mc. Cancer incidence among pesticide applicators exposed to chlorpyrifos in the agricultural health study. J Natl Cancer Inst. 2004; 96: 1781–1789.
21.
Freeman LEB, Bonner MR, Blair A, Hoppin JA, Sandler DP, Lubin JH, Dosemeci M, Lynch CF, Knott C, Alavanja MC. Cancer incidence among male pesticide applicators in the agricultural health study cohort exposed to diazinon. Amer J Epidemiol. 2005; 162: 1070–1079.
22.
Rusiecki JA, Hou L, Lee WJ, Blair A, Dosemeci M, Lubin JH, Bonner M, Samanic C, Hoppin JA, Sandler DP, Alavanja MC. Cancer incidence among pesticide applicators exposed to metolachlor in the agricultural health study. Int J Cancer. 2006; 118: 3118–3123.
23.
Hou L, Lee WJ, Rusiecki J, Hoppin JA, Blair A, Bonner MR, Lubin JH, Samanic C, Sandler DP, Dosemeci M, Alavanja MC. Pendimethalin exposure and cancer incidence among pesticide applicators. Epidemiology. 2006; 17: 302–307.
24.
Bonner MR, Freeman LEB, Hoppin JA, Koutros S, Sandler DP, Lynch CF, Hines CJ, Thomas K, Blair A, Alavanja MCR. Occupational Exposure to Pesticides and the Incidence of Lung Cancer in the Agricultural Health Study. Environ Health Perspect. 2017; Apr 125(4): 544–551. doi: 10.1289/EHP456.
25.
Purdue MP, Hoppin JA, Blai A, Dosemeci M, Alavanja MC. Occupational exposure to organochlorine insecticides and cancer incidence in the agricultural health study. Int J Cancer. 2007; 120: 642–649.
26.
Bonner MR, Lee WJ, Sandler DP, Hoppin JA, Dosemeci M, Alavanja MC. Occupational exposure to carbofuran and the incidence of cancer in the agricultural health study. Environ Health Perspect. 2005; 113: 285–289.
27.
Samanic C, Rusiecki J, Dosemeci M, Hou L, Hoppin JA, Sandler DP, Lubin J, Blair A, Alavanja MC. Cancer incidence among pesticide applicators exposed to dicamba in the agricultural health study. Environ Health Perspect. 2006; 114: 1521–1526.
28.
Christensen CH, Platz EA, Andreotti G, Blair A, Hoppin JA, Koutros S, Lynch CF, San dler DP, Alavanja MC. Coumaphos exposure and incident cancer among male participants in the agricultural health study (AHS). Environ Health Perspect. 2010; 118: 92–96.
29.
van Bemmel DM, Visvanathan K, Beane Freeman LE, Coble J, Hoppin JA, Alavanja MC. S-ethyl-N,N-dipropylthiocarbamate exposure and cancer incidence among male pesticide applicators in the agricultural health study: A prospective cohort. Environ Health Perspect. 2008; 116: 1541–1546.
30.
Lynch SM, Mahajan R, Beane Freeman LE, Hoppin, JA, Alavanja MC. Cancer incidence among pesticide applicators exposed to butylate in the agricultural health study (AHS). Environ Res. 2009; 109: 860–868.
31.
Lynch SM, Rusiecki JA, Blair A, Dosemeci M, Lubin J, Sandler D, Hoppin JA, Lynch CF, Alavanja MC. Cancer incidence among pesticide applicators exposed to cyanazine in the agricultural health study. Int J Environ Res Public Health 2013; 10: 6467.
32.
Mahajan R, Blair A, Lynch CF, Schroeder P, Hoppin JA, Sandler DP, Alavanja MC. Fonofos exposure and cancer incidence in the agricultural health study. Environ Health Perspect. 2006; 114: 1838–1842.
33.
Mahajan R, Bonner MR, Hoppin JA, Alavanja MC. Phorate exposure and incidence of cancer in the agricultural health study. Environ Health Perspect. 2006; 114: 1205–1209.
34.
Koutros S, Mahajan R, Zheng T, Hoppin JA, Ma X, Lynch CF, Blair A, Alavanja MC. Dichlorvos exposure and human cancer risk: results from the agricultural health study. Cancer Cause Control. 2008; 19: 59–65.
35.
Greenburg DL, Rusiecki J, Koutros S, Dosemeci M, Patel R, Hines CJ, Hoppin J, Alavanja MC. Cancer incidence among pesticide applicators exposed to captan in the Agricultural Health Study. Cancer Cause Control. 2008; 19: 1401–1407.
36.
Zendehdel R, Tayefeh-Rahimian R, Kabir A. Chronic exposure to chlorophenol related compounds in the pesticide production workplace and lung cancer: a meta-analysis. Asian Pac J Cancer Prev. 2014; 15(13): 5149–53.
37.
Atamas SP, Chapoval SP, Keegan AD. Cytokines in chronic respiratory diseases. F1000 Biol Rep. 2013; 5: 3.
38.
De Jong K, Boezen MH, Kromhout H, Vermeulen R, Postma DS, Judith M. Association of Occupational Pesticide Exposure With Accelerated Longitudinal Decline in Lung Function. American Journal of Epidemiology. 2014; 179(11): 1323–1330. https://doi.org/10.1093/aje/kw....
39.
Nerilo SB, Martins FA, Nerilo LB. Pesticide use and cholinesterase inhibition in small-scale agricul-tural workers in southern Brazil. Braz J Pharm Sci. 2014; 50: 783–91.
40.
Ye M, Beach J, Martin JW, Senthilselvan A. Occupational pesticide exposures and respiratory healt. Int J Environ Res Public Health. 2013; 10(12): 6442.
41.
Baur X, Budnik LT, Preisser AM. Health risks of residual fumigants in international transport containers. Dtsch Med Wochenschr. 2010; 135(11): 516–21. doi: 10.1055/s-0030-1249198. Epub 2010 Mar 10.
42.
Newman LS, Rose CS, Bresnitz EA, Rossman MD, Barnard J, Frederick M, Terrin ML, Weinberger SE, Moller DR, McLennan G, Hunninghake G, DePalo L, Baughman RP, Iannuzzi MC, Judson MA, Knatterud GL, Thompson BW, Teirstein AS, Yeager H Jr, Johns CJ, Rabin DL, Rybicki BA, Cherniack R; ACCESS Research Group. A Case Control Etiologic Study of Sarcoidosis: Environmental and Occupational Risk Factors. Am J Respir Crit Care Med. 2004 Dec 15; 170(12): 1324–30. Epub 2004 Sep 3.
43.
Slager RE, Simpson SL, Levan TD, Poole JA, Sandler DP, Hoppin JA. Rhinitis associated with pesticide use among private pesticide applicators in the agricultural health study. J Toxicol Environ Health A. 2010; 73(20): 1382–93. doi: 10.1080/15287394.2010.497443.
44.
Hoppin JA, Umbach DM, Kullman GJ, Henneberger PK, London SJ, Alavanja MCR, Sandler DP. Pesticides and other agricultural factors associated with self-reported farmer’s lung among farm residents in the Agricultural Health Study. Occup Environ Med. 2007; May 64(5): 334–342, doi: 10.1136/oem.2006.028480.
45.
Jalilian H, Neghab M, Tatar M, Taheri S. Respiratory and dermal symptoms and raised serum concentrations of biomarkers of oxidative stress among pesticide retailers. Int J Occup Environ Med. 2018; 9: 194–204.
46.
Lekei EE, Ngowi AV, London L. Pesticide retailers’ knowledge and handling practices in selected towns of Tanzania. Public Health. 2019; 174: 31–41. https://doi.org/10.1016/j.puhe....
47.
Buralli RJ, Ribeiro H, Mauad T. Respiratory Condition of Family Farmers Exposed to Pesticides in the State of Rio de Janeiro, Brazil. Int J Environ Res Public Health. 2018; 15(6): 1203.
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