Online first
Current issue
Archive
Special Issues
About the Journal
Publication Ethics
Anti-Plagiarism system
Instructions for Authors
Instructions for Reviewers
Editorial Board
Editorial Office
Contact
Reviewers
All Reviewers
2023
2022
2021
2020
2019
2018
2017
2016
General Data Protection Regulation (RODO)
BRIEF COMMUNICATION
How much do we know about genetic predisposition of hypersensitivity pneumonitis?
1
Department of Clinical Immunology, Medical University, Lublin, Poland
2
Department of Pneumonology, Oncology and Allergology, Medical University, Lublin, Poland
Corresponding author
Barbara Mackiewicz
Department of Pneumonology, Oncology and Allergology, Medical University ofLublin, 20-954, Lublin, Poland
Department of Pneumonology, Oncology and Allergology, Medical University ofLublin, 20-954, Lublin, Poland
Ann Agric Environ Med. 2022;29(2):306-308
KEYWORDS
TOPICS
Biological agents posing occupational risk in agriculture, forestry, food industry and wood industry and diseases caused by these agents (zoonoses, allergic and immunotoxic diseases)Exposure to physical hazards associated with the use of machinery in agriculture and forestry: noise, vibration, dustWork-related accidents and injuries in agriculture, forestry, food industry and wood industry: incidence, causes, social aspects and prevention
ABSTRACT
Introduction and Objective:
Hypersensitivity pneumonitis (HP) is an interstitial lung disease caused by iterative inhalation of various environmental agents. The clinical presentation is variable, acute HP commonly presents an inflammatory response, whereas the development and clinical consequences in chronic HP may be similar to IPF (idiopathic pulmonary fibrosis). The aim of the study is to present the latest discoveries regarding the genetic predisposition of HP.
Material and Methods:
The appropriate scientific literature was reviewed and analyzed.
Results:
Studies have discovered relevant gene polymorphisms in HP, including polymorphisms in the major histocompatibility complex in the metalloproteinases genes. The length of the peripheral blood leukocyte telomere has been investigated and discovered to be important. Recently, the need to study miRNAs in ILD (interstitial lung disease) has been highlighted.
Conclusions:
Exposed HP developed only in some people and a genetic susceptibility significantly increases the risk. Further more current studies on large groups of patients are needed to learn more about the genetic predisposition and risk factors of HP.
Hypersensitivity pneumonitis (HP) is an interstitial lung disease caused by iterative inhalation of various environmental agents. The clinical presentation is variable, acute HP commonly presents an inflammatory response, whereas the development and clinical consequences in chronic HP may be similar to IPF (idiopathic pulmonary fibrosis). The aim of the study is to present the latest discoveries regarding the genetic predisposition of HP.
Material and Methods:
The appropriate scientific literature was reviewed and analyzed.
Results:
Studies have discovered relevant gene polymorphisms in HP, including polymorphisms in the major histocompatibility complex in the metalloproteinases genes. The length of the peripheral blood leukocyte telomere has been investigated and discovered to be important. Recently, the need to study miRNAs in ILD (interstitial lung disease) has been highlighted.
Conclusions:
Exposed HP developed only in some people and a genetic susceptibility significantly increases the risk. Further more current studies on large groups of patients are needed to learn more about the genetic predisposition and risk factors of HP.
REFERENCES (13)
1.
Vasakova M, Morell F, Walsh S, Leslie K, Raghu G. Hypersensitivity pneumonitis: perspectives in diagnosis and management. Am J Respir Crit Care Med. 2017; 196: 680–689.
2.
Pereira CA, Gimenez A, Kuranishi L, Storrer K. Chronic hypersensitivity pneumonitis. J Asthma Allergy. 2016; 9: 171–181. doi:10.2147/JAA.S81540.
3.
Chan AL, Juarez MM, Leslie KO, Ismail HA, Albertson TE. Bird fancier’s lung: a state-of-the-art review. Clin Rev Allergy Immunol. 2012; 43(1–2): 69–83.
4.
Johansson E, Boivin GP, Yadav JS. Early immunopathological events in acute model of mycobacterial hypersensitivity pneumonitis in mice. J Immunotoxicol. 2017; 14: 77–88.
5.
Ley B, Newton CA, Arnould I, et al. The MUC5B promoter polymorphism and telomere length in patients with chronic hypersensitivity pneumonitis: an observational cohort-control study. Lancet Respir Med. 2017; 5(8): 639–647. doi:10.1016/S2213-2600(17)30216-3.
6.
Ley B, Torgerson DG, Oldham JM, et al. Rare protein-altering telomere-related gene variants in patients with chronic hypersensitivity pneumonitis. Am J Respir Crit Care Med. 2019; 200(9): 1154–1163. doi:10.1164/rccm.201902-0360OC.
7.
Santiago-Ruiz L, Buendía-Roldán I, Pérez-Rubio G, et al. MMP2 Polymorphism affects plasma matrix metalloproteinase (MMP)-2 levels, and correlates with the decline in lung function in hypersensitivity pneumonitis positive to autoantibodies patients. Biomolecules. 2019; 9(10): 574. doi:10.3390/biom9100574.
8.
Kondoh K, Usui Y, Ohtani Y, Inase N, Miyake S, Yoshizawa Y. Proinflammatory and anti-inflammatory cytokine gene polymorphisms in hypersensitivity pneumonitis. J Med Dent Sci. 2006; 53(1): 75–83.
9.
Furukawa H, Oka S, Shimada K, et al. Genetics of interstitial lung disease: vol de nuit (night flight). Clinical Medicine Insights: Circulatory, Respiratory and Pulmonary Medicine 2015; 9(S1)1–7. doi: 10.4137/CCRPRPM.S23283.
10.
Falfan-Valencia R, Camarena A, Pineda CL. Genetic susceptibility to multicase hypersensitivity pneumonitis is associated with the TNF-238 GG genotype of the promoter region and HLA-DRB1*04 bearing HLA haplotypes. Respir Med. 2014; 108(1): 211–217.
11.
Aquino-Galvez A, Camarena A, Montano M, et al. Transporter associated with antigen processing (TAP) 1 gene polymorphisms in patients with hypersensitivity pneumonitis. Exp Mol Pathol. 2008; 84(2): 173–177. doi:10.1016/j.yexmp.2008.01.002.
12.
Kiszałkiewicz J, Piotrowski W, Brzeziańska-Lasota E. Signaling pathways and their miRNA regulators involved in the etiopathology of idiopathic pulmonary fibrosis (IPF) and hypersensitivity pneumonitis (HP). Adv Respir Med. 2017; 85(3): 169–178. doi:10.5603/ARM.2017.0029.
13.
Croston TL, Lemons AR, Beezhold DH, Green BJ. MicroRNA regulation of host immune responses following fungal exposure. Front Immunol. 2018; 9:170. Published 2018 Feb 7. doi:10.3389/fimmu.2018.00170.
Share
RELATED ARTICLE
| eISSN: | 1898-2263 |
| ISSN: | 1232-1966 |
Improvement of visual identification of the journal - task financed under the agreement No. 618/P-DUN/2019 by the Minister of Science and Higher Education allocated to the activities of disseminating science.
Generation of the DOI (Digital Object Identifier) - task financed under the agreement No. 618/P-DUN/2019 by the Minister of Science and Higher
© 2006-2024 Journal hosting platform by Bentus
We process personal data collected when visiting the website. The function of obtaining information about users and their behavior is carried out by voluntarily entered information in forms and saving cookies in end devices. Data, including cookies, are used to provide services, improve the user experience and to analyze the traffic in accordance with the Privacy policy. Data are also collected and processed by Google Analytics tool (more).
You can change cookies settings in your browser. Restricted use of cookies in the browser configuration may affect some functionalities of the website.
You can change cookies settings in your browser. Restricted use of cookies in the browser configuration may affect some functionalities of the website.
