Haemodynamic parameters in postmenopausal women – beneficial effect of moderate continuous exercise training
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Department of Family Medicine, Medical University, Gdansk, Poland
University of Leipzig, Leipzig, Germany
Department of Physiology, Gdansk University of Physical Education and Sport, Gdansk, Poland
Andrzej Molisz   

Department of Family Medicine, Medical University of Gdansk, Gdansk, Poland
Introduction and objective:
Physical effort plays a positive role in reducing the risk of cardiovascular diseases. The aim of this study was to assess the cardiovascular status in postmenopausal women after several years of regular amateur training.

Material and methods:
A total of 55 generally healthy females aged 50–70 years, of whom 38 were members of a senior exercise group and 17 comprised a control group, were enrolled in the study. Parameters of blood flow, vascular resistance, myocardial contractility and thoracic fluid content were measured in a 10-minute supine resting test by impedance cardiography. Thereafter, central blood pressure, augmentation index and pulse wave velocity were measured by applanation tonometry.

Exercising women have a better outcome than the control group, when evaluated both with impedance cardiography and with applanation tonometry. They have a lower heart rate – HR (65.1 vs 71.5; p = 0.033), higher blood flow (stroke index – SI, 58.6 vs 50.3; p = 0.040), better myocardial contractility (acceleration index – ACI, 108.8 vs 88.1; p = 0.027), higher preload (thoracic fluid content index – TFCI, 20.5 vs 18.1; p = 0.002), lower afterload (systemic vascular resistance index – SVRI, 1972.9 vs 2110.5; p = 0.026), lower central systolic blood pressure – cBPsys (119.0 vs 129.5; p = 0.037), lower augmentation pressure – AP (10.3 vs 15.0; p = 0.044) and lower pulse wave velocity – PWV (7.4 vs 8.4; p = 0.001).

Regular moderate continuous aerobic exercise training has a beneficial impact on the cardiovascular system in postmenopausal women.

Lloyd-Jones DM, Leip EP, Larson MG, D’Agostino RB, Beiser A, Wilson PWF, et al. Prediction of lifetime risk for cardiovascular disease by risk factor burden at 50 years of age. Circulation 2006; 113: 791–8.
Anderson KM, Odell PM, Wilson PWF, Kannel WB. Cardiovascular-disease risk profiles. Am Heart J. 1991; 121: 293–8.
Wieczorowska-Tobis K, Kostka T, Borowicz AM. Fizjoterapia w geriatrii. Wydawnictwo Lekarskie PZWL; 2011.
Grześkowiak A, Stanimir A. Wielowymiarowa analiza wybranych aspektów postaw życiowych młodszych i starszych pokoleń Europejczyków. Pr Nauk Uniw Ekon We Wrocławiu Tak 2011; 18: 157–65.
Kowaleski JT, Majdzińska A. Starzenie sie populacji krajów Unii Europejskiej – nieodległa przeszłość i prognoza. Studia Demogr 2012: 57–80.
Nocon M, Hiemann T, Mueller-Riemenschneider F, Thalau F, Roll S, Willich SN. Association of physical activity with all-cause and cardiovascular mortality: a systematic review and meta-analysis. Eur J Cardiovasc Prev Rehabil. 2008; 15: 239–46.
Grzanka-Tykwińska A, Kędziora-Kornatowska K. Znaczenie wybranych form aktywności w życiu osób w podeszłym wieku. Gerontol Pol. 2010; 18: 29–32.
Christou DD, Seals DR. Decreased maximal heart rate with aging is related to reduced beta-adrenergic responsiveness but is largely explained by a reduction in intrinsic heart rate. J Appl Physiol. 2008; 105: 24–9.
Docherty JR. Cardiovascular-responses in aging – a review. Pharmacol Rev. 1990; 42: 103–25.
Schuler G, Adams V, Goto Y. Role of exercise in the prevention of cardiovascular disease: results, mechanisms, and new perspectives. Eur Heart J. 2013; 34: 1790.
Wen CP, Wai JPM, Tsai MK, Yang YC, Cheng TYD, Lee MC, et al. Minimum amount of physical activity for reduced mortality and extended life expectancy: a prospective cohort study. Lancet 2011; 378: 1244–53.
Sattelmair J, Pertman J, Ding EL, Kohl HW, Haskell W, Lee IM. Dose Response Between Physical Activity and Risk of Coronary Heart Disease A Meta-Analysis. Circulation 2011; 124: 789-U84.
Kokkinos PF, Andreas PE, Coutoulakis E, Colleran JA, Narayan P, Dotson CO, et al. Determinants of exercise blood pressure response in normotensive and hypertensive women: role of cardiorespiratory fitness. J Cardiopulm Rehabil. 2002; 22: 178–83.
Panigrahi G, Pedersen A, Boudoulas H. Effect of physical training on exercise hemodynamics in patients with stable coronary artery disease. The use of impedance cardiography. J Med. 1983; 14: 363–73.
Goldberg MJ, Boutcher SH, Boutcher YN. The effect of 4 weeks of aerobic exercise on vascular and baroreflex function of young men with a family history of hypertension. J Hum Hypertens 2012; 26: 644–9.
Piepoli MF, Guazzi M, Boriani G, Cicoira M, Corra U, Dalla Libera L, et al. Exercise intolerance in chronic heart failure: mechanisms and therapies. Part I. Eur J Cardiovasc Prev Rehabil. 2010; 17: 637–42.
Newman DG, Callister R. The non-invasive assessment of stroke volume and cardiac output by impedance cardiography: a review. Aviat Sp Env Med. 1999; 70: 780–9.
Strobeck JE, Silver MA, Ventura H. Impedance cardiography: noninvasive measurement of cardiac stroke volume and thoracic fluid content. Congest Hear Fail. 2000; 6: 56–9.
Fellahi JL, Caille V, Charron C, Deschamps-Berger PH, Vieillard-Baron A. Noninvasive assessment of cardiac index in healthy volunteers: a comparison between thoracic impedance cardiography and Doppler echocardiography. Anesth Analg. 2009; 108: 1553–9.
Lorne E, Mahjoub Y, Diouf M, Sleghem J, Buchalet C, Guinot PG, et al. Accuracy of impedance cardiography for evaluating trends in cardiac output: a comparison with oesophageal Doppler. Br J Anaesth. 2014; 113: 596–602.
Sodolski T, Kutarski A. Impedance cardiography: A valuable method of evaluating haemodynamic parameters. Cardiol J. 2007; 14: 115–26.
Rada MA, Cuffaro PE, Galarza CR, Barochiner J, Alfie J, Posadas Martinez ML, et al. Predictive value of non-invasive hemodynamic measurement by means of impedance cardiography in hypertensive subjects older than 50 years of age. Clin Exp Hypertens. 2014; 36: 280–4.
Edmunds AT, Godfrey S, Tooley M. Cardiac output measured by transthoracic impedance cardiography at rest, during exercise and at various lung volumes. Clin Sci. 1982; 63: 107–13.
Farinatti PT V, Soares PPS. Cardiac output and oxygen uptake relationship during physical effort in men and women over 60 years old. Eur J Appl Physiol. 2009; 107: 625–31.
Franke WD, Taylor KA. Exercise training mode affects the hemodynamic responses to lower body negative pressure in women. Eur J Appl Physiol Occup Physiol. 1996; 73: 169–74.
Miles DS, Cox MH, Verde TJ, Gotshall RW. Application of impedance cardiography during exercise. Biol Psychol. 1993; 36: 119–29.
Miles DS, Gotshall RW. Impedance cardiography: noninvasive assessment of human central hemodynamics at rest and during exercise. Exerc Sport Sci Rev. 1989; 17: 231–63.
Siebert J, Zielinska D, Trzeciak B, Bakula S. Haemodynamic response during exercise testing in patients with coronary artery disease undergoing a cardiac rehabilitation programme. Biol Sport 2011; 28: 189–93.
Adji A, O’Rourke MF, Namasivayam M. Arterial Stiffness, Its Assessment, Prognostic Value, and Implications for Treatment. Am J Hypertens. 2011; 24: 5–17.
Hamilton PK, Lockhart CJ, Quinn CE, McVeigh GE. Arterial stiffness: clinical relevance, measurement and treatment. Clin Sci. 2007; 113: 157–70.
Van Bortel LM, Laurent S, Boutouyrie P, Chowienczyk P, Cruickshank JK, De Backer T, et al. Expert consensus document on the measurement of aortic stiffness in daily practice using carotid-femoral pulse wave velocity. J Hypertens. 2012; 30: 445–8.
Guimaraes G V, Ciolac EG, Carvalho VO, D’Avila VM, Bortolotto LA, Bocchi EA. Effects of continuous vs. interval exercise training on blood pressure and arterial stiffness in treated hypertension. Hypertens Res. 2010; 33: 627–32.
Tjonna AE, Lee SJ, Rognmo O, Stolen TO, Bye A, Haram PM, et al. Aerobic interval training versus continuous moderate exercise as a treatment for the metabolic syndrome – A pilot study. Circulation 2008; 118: 346–54.
Wisloff U, Stoylen A, Loennechen JP, Bruvold M, Rognmo O, Haram PM, et al. Superior cardiovascular effect of aerobic interval training versus moderate continuous training in heart failure patients – A randomized study. Circulation 2007; 115: 3086–94.
Cornelissen VA, Fagard RH. Effects of endurance training on blood pressure, blood pressure-regulating mechanisms, and cardiovascular risk factors. Hypertension 2005; 46: 667–75.
Fagard RH, Cornelissen VA. Effect of exercise on blood pressure control in hypertensive patients. Eur J Cardiovasc Prev Rehabil. 2007; 14: 12–7.
Chaui-Berlinck JG, Monteiro LHA. Frank-Starling mechanism and short-term adjustment of cardiac flow. J Exp Biol. 2017; 220: 4391–8.
de Tombe PP, EDJ ter Keurs H. Cardiac muscle mechanics: Sarcomere length matters. J Mol Cell Cardiol. 2016; 91: 148–50.
Schotola H, Sossalla ST, Renner A, Gummert J, Danner BC, Schott P, et al. The contractile adaption to preload depends on the amount of afterload. ESC Hear Fail. 2017; 4: 468–78.