RESEARCH PAPER
Effects of growth hormone and testosterone therapy on aerobic and anaerobic fitness , body composition and lipoprotein profile in middle-aged men
 
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1
Department of Sports Theory, Academy of Physical Education, Katowice, Poland
2
Department of Sports Training, Academy of Physical Education, Katowice, Poland
3
Department of Individual Sports, Academy of Physical Education, Katowice, Poland
4
Department of Methodology, Statistics and Informatics Systems, Academy of Physical Education, Katowice, Poland
 
Ann Agric Environ Med. 2014;21(1):156–160
KEYWORDS
ABSTRACT
Introduction. Andropause and aging are associated with neuroendocrine dysfunctions. Growth hormone and testosterone play a significant role in several processes affecting adaptation and thereby also everyday functioning. The aim of this research project was to evaluate the effects of recombinant human growth hormone and testosterone enanthate injections on body mass and body composition, aerobic and anaerobic fitness and lipid profile in middle-aged men. Materials and method. The research group was comprised of 14 men aged 45 – 60 years. Two series of laboratory analyses were performed. Independent tests were carried out at baseline and after 12 weeks of the experiment. The data were analyzed using Statistica 9.1 software. Results. A two-way repeated measures ANOVA revealed a statistically significant effect of the intervention programme on fat-free mass (η2=0.34), total body fat (η2=0.79), total cholesterol (η2=0.30), high-density lipoprotein cholesterol (η2=0.31), low-density lipoprotein cholesterol (η2=0.42), triglyceride (η2=0.28), testosterone (η2=0.52), insulin-like growth factor 1 (η2=0.47) and growth hormone (η2=0.63). Furthermore, ANOVA revealed a statistically significant effect of the rhGH and T treatment on maximal oxygen uptake (η2=0.63), anaerobic threshold (η2=0.61) and maximal work rate (η2=0.53). Conclusion. It should be emphasized that the lipid profile was affected not only by rhGH+T replacement therapy, but also by the prescribed physical activity programme. The strength and endurance fitness programme alone did not cause significant changes in body mass and composition, nor the anaerobic and aerobic capacity. On the other hand, the rhGH=T treatment stimulated these changes significantly.
 
REFERENCES (25)
1.
De Boer H, Blok GJ, Voerman HJ, De Vries PM. van der Veen EA. Body composition in adult growth hormone-deficient men, assessed by anthropometry and bioimpedance analysis. J. Clin Endocrinal Metab. 1992; 75: 833–837.
 
2.
Bhasin S, Storer TW, Berman N, Callegari C, Clevenger B, Phillips J, Bunnell TJ, Tricker R, Shirazi A, Casaburi R. The effects of supraphysiological doses of testosterone on muscle size and strength in normal men. N Engl J Med. 1996; 335: 1–7.
 
3.
Singh R, Artaza JN, Taylor WE, Gonzalez-Cadavid NF, Bhasin S. Androgens stimulate myogenic differentiation and inhibit adipogenesis in C3H 10T1/2 pluripotent cells through an androgen receptormediated pathway. Endocrinology. 2003; 144(11): 5081–5088.
 
4.
Kraemer WJ, Hakkinen K, Newton RU, Nindl BC, Volek JS, McCormick M, Gotshalk LA, Gordon SE, Fleck SJ, Campbell WW, Putukian M, Evans WJ. Effects of heavy-resistance training on hormonal response patterns in younger vs. older men. J. Appl Physiol. 1999; 87(3): 982–992.
 
5.
Hakkinen K. Pakarinen A. Acute hormonal responses to heavy resistance exercise in men and women at different ages. Int J Sports Med. 1995; 16: 507–513.
 
6.
Whitehead H, Boreham C, McIlrath EM, Sheridan B, Kennedy L, Atkinson AB. Growth hormone treatment of adults with growth hormone deficiency; results of a 13-month placebo controlled crossover study. Clin Endocrinol. 1992; 36: 45–52.
 
7.
Cuneo RC, Salomon F, Wiles CM, Hesp R, Sonksen PH. Growth hormone treatment improves serum lipids aPnd lipoproteins in adults with growth hormone deficiency. Metabolism. 1993; 42: 1519–1523.
 
8.
Friedl KE, Dettori JR, Hannan CJ Jr, Patience TH, Plymate SR. Comparison of the effect of high-dose testosterone and 19-nortestosterone to a replacement dose of testosterone on strength and body composition in normal men. J Steroid Biochem Mol Biol. 1991; 40: 607–612.
 
9.
Griggs RC, Kingston W, Jozefowicz RF, Herr BE, Forbes G, Halliday D. Effect of testosterone on muscle mass and protein synthesis. J Appl Physiol. 1989; 66(1): 498–503.
 
10.
Salomon F, Cuneo RC, Hesp R, Sonksen PH. The effect of treatment with recombinant human growth hormone on body composition and metabolism in adults with growth hormone deficiency. N Engl J Med. 1989; 321: 1797–1803.
 
11.
Cuneo RC, Salomon F, Wiles CM, Hesp R, Sonksen PH. Growth hormone treatment in growth hormone-deficient adults. I. Effects on muscle mass and strength. J Appl Physiol. 1991; 70: 688–694.
 
12.
Yarasheski KE. Growth hormone effects on metabolism, body composition, muscle mass, and strength. In: Holloszy JO, ed. Exercise and Sports Science Reviews. Williams and Wilkins, Baltimore MD 1994; 22: 285–312.
 
13.
Hopkins WG. Linear Models and Effect Magnitudes for Research, Clinical and Practical Applications. Sportscience 2010, 14: 49–57.
 
14.
Friedl KE, Dettori JR, Hannan CJ Jr, Patience TH, Plymate SR. Comparison of the effect of high-dose testosterone and 19-nortestosterone to a replacement dose of testosterone on strength and body composition in normal men. J Steroid Biochem Mol Biol. 1991; 40: 607–613.
 
15.
Urban RJ, Bodenburg YH, Gilkison C, Foxworth J, Coggan AR, Wolfe RR, Ferrando A. Testosterone administration to elderly men increases skeletal muscle strength and protein synthesis. American Journal of Physiology 1995; 269: 820–826.
 
16.
Chihara K, Kato Y, Kohno H, Takano K, Tanaka T, Teramoto A, Shimatsu A. Safety and efficacy of growth hormone (GH) during extended treatment of adult Japanese patients with GH deficiency (GHD). Growth Horm Igf Res. 2008; 18(4): 307–317.
 
17.
Rudman D, Feller AG, Nagraj HS, Gergans GA, Lalitha PY, Goldberg AF, Schlenker RA, Cohn L, Rudman IW, Mattson DE. Effects of human growth hormone in men over 60 years old. N Engl J Med. 1990; 323: 1–6.
 
18.
Moller J, Moller N, Frandsen E, Wolthers T, Jørgensen JO, Christiansen JS. Blockade of the renin-angiotensin-aldosterone system prevents growth hormone-induced fluid retention in humans. Am J Physiol. 1997; 272: 803–808.
 
19.
Jorgensen JO, Pedersen SA, Thuesen L, Jørgensen J, IngemannHansen T, Skakkebaek NE, Christiansen JS. Beneficial effects of growth hormone treatment in GH-deficient adults. Lancet. 1989 3; 1(8649): 1221–1225.
 
20.
Blackman MR, Sorkin JD, Munzer T, Bellantoni MF, Busby-Whitehead J, Stevens TE, Jayme J, O’Connor KG, Christmas C, Tobin JD, Stewart KJ, Cottrell E, St. Clair C, Pabst KM, Harman SM. Growth hormone and sex steroid administration in healthy aged women and men: a randomized controlled trial. J Am Med Assoc (JAMA). 2002; 288: 2282–2292.
 
21.
Yarasheski KE, Zachwieja JJ, Campbell JA, Bier DM. Effect of growth hormone and resistance exercise on muscle growth and strength in older men. Am J Physiol. 1995; 268: 268–276.
 
22.
Fryburg DA. Insuline-like growth factor exerts growth hormone and insulin-like actions on human muscle protein metabolism. Am J Physiol. 1994; 267: 331–336.
 
23.
Rodriguez-Arnao J, Jabbar A, Fulcher K, Besser GM, Ross, RJ. Effects of growth hormone replacement on physical performance and body composition in GH deficient adults. Clin Endocrinol (Oxf). 1999; 51: 5360.
 
24.
Isidori AM, Giannetta E, Greco EA, Gianfrilli D, Bonifacio V, Isidori A, Lenzi A, Fabbri A. Effects of testosterone on body composition, bone metabolism and serum lipid profile in middle aged men: a metaanalysis. Clin Endocrinol (Oxf). 2005; 63: 280–293.
 
25.
Munzer T, Harman SM, Sorkin JD, Blackman MR. Growth hormone and sex steroid effects on serum glucose, insulin, and lipid concentrations in healthy older women and men. J Clin Endocrinol Metab. 2009; 94(10): 3833–3841.
 
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