CASE REPORT
Polysynovitis in a horse due to Borrelia burgdorferi sensu lato infection – Case study
 
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Centro di Studio del cavallo sportivo, Department of Veterinary Medicine, University of Perugia, Italy
CORRESPONDING AUTHOR
Fabrizio Passamonti   

Centro di Studio del cavallo sportivo, Department of Veterinary Medicine, University of Perugia, Italy
 
Ann Agric Environ Med. 2015;22(2):247–250
KEYWORDS
ABSTRACT
Lyme borreliosis (LB) is a multi-systemic tick-borne disease affecting both humans and animals, including horses, and is caused by a group of interrelated spirochetes classified within the Borrelia burgdorferi sensu lato (s.l.) complex. Despite the high reported seroprevalence in the European equine population for B. burgdorferi s.l., to-date no documented clinical cases have been described. A 6-year-old Paint gelding was referred with a history of three weeks of fever, intermittent lameness and digital flexor tendon sheath effusion of the right hind limb. Based on a strict diagnostic protocol, which included serological tests for infectious diseases and molecular investigations, a final diagnosis was made of polysynovitis due to B. burgdorferi s.l. infection. An unreported aspect observed in this case was the absence of the pathogen DNA in two of the affected joints. To the authors’ knowledge, the case described represents the first documented clinical case of equine LB in Italy. Moreover, the absence of pathogen DNA in two of the affected joints observed in this case revealed a possible similarity with the same condition described in humans, where an immunomediated pathogenesis for arthropathy due to B. burgdorferi s.l. infection is suspected. Since humans and horses share the same habitat, this report supports the role of the horse as potential sentinel for human biological risk.
 
REFERENCES (20)
1.
Ebani VV, Bertelloni F, Pinzauti P, Cerri D. Seroprevalence of Leptospira spp. and Borrelia burgdorferi sensu lato in Italian horses. Ann Agric Environ Med. 2012; 19: 237–240.
 
2.
Butler CM, Houwers DJ, Jongejan F, van der Kolk JH. Borrelia burgdorferi infections with special reference to horses. A review. Vet Q. 2005; 27:146–156.
 
3.
Stefanciková A, Adaszek Ł, Pet’ko B, Winiarczyk S, Dudinák V. Serological evidence of Borrelia burgdorferi sensu lato in horses and cattle from Poland and diagnostic problems of Lyme borreliosis. Ann Agric Environ Med. 2008; 15: 37–43.
 
4.
Hansen MG, Christoffersen M, Thuesen LR, Petersen MR, Bojesen AM. Seroprevalence of Borrelia burgdorferi sensu lato and Anaplasma phagocytophilum in Danish horses. Acta Vet Scand. 2010; 18: 52–53.
 
5.
Crovato F, Nazzari G, Fumarola D, Rovetta G, Cimmino MA, Bianchi G. Lyme disease in Italy: first reported case. Ann Rheum Dis. 1985; 44: 570–571.
 
6.
Veronesi F, Laus F, Passamonti F, Tesei B, Piergili Fioretti D, Genchi C. Occurrence of Borrelia lusitaniae infection in horses. Vet Microbiol. 2012; 160: 535–538.
 
7.
Laus F, Veronesi F, Passamonti F, Paggi E, Cerquetella M, Hyatt D, et al. Prevalence of tick borne pathogens in horses from Italy. J Vet Med Sci. 2013; 75: 715–720.
 
8.
Jacobsen S, Thomsen MH, Nanni S. Concentrations of serum amyloid A in serum and synovial fluid from healthy horses and horses with joint disease. Am J Vet Res. 2006; 67: 1738–1742.
 
9.
Burgess EC, Gillette D, Pickett JP. Arthritis and panuveitis as manifestations of Borrelia burgdorferi infection in a Wisconsin pony. J Am Vet Med Assoc. 1986; 189: 1340–1342.
 
10.
Bertolotti L, Tomassone L, Tramuta C, Grego E, Amore G, Ambrogi C et al. Borrelia lusitaniae and spotted fever group rickettsiae in Ixodes ricinus (Acari: Ixodidae) in Tuscany, central Italy. J Med Entomol. 2006; 43: 159–165.
 
11.
Ragagli C, Bertolotti L, Giacobini M, Mannelli A, Bisanzio D, Amore G, et al. Transmission dynamics of Borrelia lusitaniae and Borrelia afzelii among Ixodes ricinus, lizards, and mice in Tuscany, central Italy. Vector Borne Zoonotic Dis. 2011; 11: 21–28.
 
12.
Tomassone L, Grego E, Auricchio D, Iori A, Giannini F, Rambozzi L. Lyme borreliosis spirochetes and spotted fever group rickettsiae in ixodid ticks from Pianosa island, Tuscany Archipelago, Italy. Vector Borne Zoonotic Dis. 2013; 13: 84–91.
 
13.
Rizzoli A, Hauffe H, Carpi G, Vourc HG, Neteler M, Rosa R. Lyme borreliosis in Europe. Euro Surveill. 2011; 16: 19906.
 
14.
Collares-Pereira M, Couceiro S, Franca I, Kurtenbach K, Schäfer SM, Vitorino L, et al. First isolation of Borrelia lusitaniae from a human patient. J Clin Microbiol. 2004; 42: 1316–1318.
 
15.
Egenvall A, Franzén P, Gunnarsson A, Engvall EO, Vågsholm I, Wikström UB, et al. Cross-sectional study of the seroprevalence to Borrelia burgdorferi sensu lato and granulocytic Ehrlichia spp. and demographic, clinical and tick-exposure factors in Swedish horses. Prev Vet Med. 2001; 49: 191–208.
 
16.
Steere AC, Duray PH, Kauffmann DJ, Wormser GP. Unilateral blindness caused by infection with the Lyme disease spirochete, Borrelia burgdorferi. Ann Intern Med. 1985; 103: 382–384.
 
17.
Reed SM, Toribio R. Lyme disease in horses. In: Reed SM, Bayly WM, Sellon DC, et al. Equine Internal Medicine ed 3. St Louis, Saunders Elsevier, 2010.p.644–646.
 
18.
Nardelli DT, Callister SM, Schell RF. Lyme arthritis: current concepts and a change in paradigm. Clin. Vaccine Immunol. 2008; 15: 21–34.
 
19.
Hirschfeld M, Kirschning CJ, Schwandner R, Wesche H, Weis JH, Wooten RM, et al. Cutting edge: inflammatory signaling by Borrelia burgdorferi lipoproteins is mediated by Toll-like receptor 2. J Immunol. 1999; 163: 2382–2386.
 
20.
Fairweather D, Kaya Z, Shellam GR, Lawson CM, Rose NR. From infection to autoimmunity. J Autoimmun. 2001; 16; 175–186.
 
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