RESEARCH PAPER
Red LED light therapy for telogen effluvium in the course of long COVID in patients with and without androgenetic alopecia
1
Department of Dermatology, Venereology and Paediatric Dermatology, Medical University, Lublin, Poland
2
Department of Cosmetology and Aesthetic Medicine, Medical University, Lublin, Poland
3
Orthopaedic and Sports Traumatology Department, Carolina Medical Center, Warsaw, Poland
4
Department of Machine Design and Mechatronics, Faculty of Mechanical Engineering, University of Technology, Lublin,
Poland
5
Department of Medical Chemistry, Doctoral School, Medical University, Lublin, Poland
6
Department of Medical Statistics, School of Public Health, Centre of Postgraduate Medical Education, Warsaw, Poland
7
Institute of Optoelectronics, The Military University of Technology, Poland
Corresponding author
Agnieszka Gerkowicz
Department of Dermatology, Venereology and Paediatric Dermatology, Medical University of Lublin, Staszica 11, 20-081, Lublin, Poland
Department of Dermatology, Venereology and Paediatric Dermatology, Medical University of Lublin, Staszica 11, 20-081, Lublin, Poland
KEYWORDS
TOPICS
ABSTRACT
Introduction and objective:
Photobiomodulation with the use of light-emitting diodes (LEDs) seems to be a promising option for long COVID. This retrospective study evaluates the efficiency of LED irradiation in the treatment of TE in the course of long COVID in patients with and without androgenetic alopecia.
Material and methods:
A retrospective single-centre chart review of patients with post-COVID hair loss was performed. 140 patients enrolled to the study were divided into four groups depending on the type of alopecia and treatment: 1) telogen effluvium with LED therapy (TE LED+), 2) telogen effluvium without LED therapy (TE LED-), 3) telogen effluvium and androgenetic alopecia with LED therapy (TE+AGA LED+), and 4) telogen effluvium and androgenetic alopecia without LED therapy (TE+AGA LED-). Clinical and trichoscopic parameters were compared.
Results:
After 12 weeks, cessation of hair loss and a negative hair pull test were more common in TE LED+ and TE+AGA LED+ in comparison to the patients without LED therapy (p<0.001, p=0.035, respectively). An increased number of thick hairs and an increased number of hairs within follicular units were more common in patients treated with LED irradiation, regardless of the type of alopecia, compared to the patients without LED therapy.
Conclusions:
The study revealed that LED therapy is safe, well tolerated and seems to be a promising therapeutic option for TE in patients with long COVID. It can be used as adjuvant therapy leading to faster reduction of hair loss, enhancing hair regrowth as well as hair shaft thickness and density.
Photobiomodulation with the use of light-emitting diodes (LEDs) seems to be a promising option for long COVID. This retrospective study evaluates the efficiency of LED irradiation in the treatment of TE in the course of long COVID in patients with and without androgenetic alopecia.
Material and methods:
A retrospective single-centre chart review of patients with post-COVID hair loss was performed. 140 patients enrolled to the study were divided into four groups depending on the type of alopecia and treatment: 1) telogen effluvium with LED therapy (TE LED+), 2) telogen effluvium without LED therapy (TE LED-), 3) telogen effluvium and androgenetic alopecia with LED therapy (TE+AGA LED+), and 4) telogen effluvium and androgenetic alopecia without LED therapy (TE+AGA LED-). Clinical and trichoscopic parameters were compared.
Results:
After 12 weeks, cessation of hair loss and a negative hair pull test were more common in TE LED+ and TE+AGA LED+ in comparison to the patients without LED therapy (p<0.001, p=0.035, respectively). An increased number of thick hairs and an increased number of hairs within follicular units were more common in patients treated with LED irradiation, regardless of the type of alopecia, compared to the patients without LED therapy.
Conclusions:
The study revealed that LED therapy is safe, well tolerated and seems to be a promising therapeutic option for TE in patients with long COVID. It can be used as adjuvant therapy leading to faster reduction of hair loss, enhancing hair regrowth as well as hair shaft thickness and density.
REFERENCES (52)
1.
Lechner-Scott J, Levy, M, Hawkes C, et al. Long COVID or Post COVID-19 Syndrome. Mul Scler Relat Disord. 2021;55:103268. https://doi.org/10.1016/j.msar....
2.
Lopez-Leon S, Wegman-Ostrosky T, Perelman C, et al. More than 50 Long-Term Effects of COVID-19: A Systematic Review and Meta-Analysis. Sci Rep. 2021;11(1):16144. https://doi.org/10.1038/s41598....
3.
Nguyen B, Tosti A. Alopecia in Patients with COVID-19: A Systematic Review and Meta-Analysis. JAAD Int.2022;7: 67–77. https://doi.org/10.1016/j.jdin....
4.
Popescu MN, Berteanu M, Beiu C, et al. Complementary Strategies to Promote Hair Regrowth in Post-COVID-19 Telogen Effluvium. Clin Cosmet Investig Dermat. 2022;15:735–743. https://doi.org/10.2147/CCID.S....
5.
Inamadar A. Covid Induced Telogen Effluvium (CITE): An Insight. Indian Dermatol Online J. 2022;13(4):445. https://doi.org/10.4103/idoj.i....
6.
Mieczkowska, K., Deutsch A., Borok J, et al. Telogen Effluvium: A Sequela of COVID-19. Int J Dermatol. 2021;60(1):122–124. https://doi.org/10.1111/ijd.15....
7.
Abrantes T F, Artounian KA, Falsey R, et.al Time of Onset and Duration of Post-COVID-19 Acute Telogen Effluvium. J Am Acad Dermatol. 2021;85(4):975–976. https://doi.org/10.1016/j.jaad....
8.
Rivetti N, Barruscotti S. Management of Telogen Effluvium during the COVID-19 Emergency: Psychological Implications. Dermatol Ther. 2020;33(4). https://doi.org/10.1111/dth.13....
9.
Aida G, Daniela Guzman S, Alireza F, et al. COVID-19 Can Exacerbate Pattern Hair Loss and Trigger Telogen Effluvium – The Role of Proteoglycan Replacement Therapy with Nourkrin® in Clinical Treatment of COVID-19 Associated Hair Loss. J Dermatol Res Ther. 2021;7(2):103. https://doi.org/10.23937/2469-....
10.
Gentile P. Preliminary Investigation on Micro-Needling with Low-Level LED Therapy and Growth Factors in Hair Loss Related to COVID-19. JCM. 2022;11(19):5760. https://doi.org/10.3390/jcm111....
11.
Avci P, Gupta A, Sadasivam M, et al. Low-Level Laser (Light) Therapy (LLLT) in Skin: Stimulating, Healing, Restoring. Semin Cutan Med Surg. 2013;32(1):41–52.
12.
Torres AE, Lim HW. Photobiomodulation for the Management of Hair Loss. Photodermatol Photoimmunol Photomed. 2021;37(2):91–98. https://doi.org/10.1111/phpp.1....
13.
Marashian SM, Hashemian M, Pourabdollah M, et al. A. Photobiomodulation Improves Serum Cytokine Response in Mild to Moderate COVID-19: The First Randomized, Double-Blind, Placebo Controlled, Pilot Study. Front Immunol. 2022;13:929837. https://doi.org/10.3389/fimmu.....
14.
Pereira PC, De Lima C J, Fernandes AB, et al. Cardiopulmonary and Hematological Effects of Infrared LED Photobiomodulation in the Treatment of SARS-COV2. J Photochem Photobiol B. 2023;238:112619. https://doi.org/10.1016/j.jpho....
15.
Bowen R, Arany PR. Use of Either Transcranial or WHOLE-BODY Photobiomodulation Treatments Improves COVID-19 Brain Fog. J Biophotonics. 2023;16(8):e202200391. https://doi.org/10.1002/jbio.2....
16.
Kwon TR, Moon DW, Yoon BH, et al. Hair Growth Promotion by Photobiomodulation Therapy Using Different Parameters: Animal Study. Med Lasers. 2023;12(1):34–43. https://doi.org/10.25289/ML.23....
17.
Gupta AK, Foley KA. A Critical Assessment of the Evidence for Low-Level Laser Therapy in the Treatment of Hair Loss. Dermatol Surg. 2017;43(2):188–197. https://doi.org/10.1097/DSS.00....
18.
Choi YS, Zhang Y, Xu M, et al. Distinct Functions for Wnt/ß-Catenin in Hair Follicle Stem Cell Proliferation and Survival and Interfollicular Epidermal Homeostasis. Cell Stem Cell. 2013;13(6):720–733. https://doi.org/10.1016/j.stem....
19.
Stepanov YV, Golovynska I, Golovynskyi S, et al. Red and near Infrared Light-Stimulated Angiogenesis Mediated via Ca2+ Influx, VEGF Production and NO Synthesis in Endothelial Cells in Macrophage or Malignant Environments. J Photochem Photobiol B. 2022;227:112388. https://doi.org/10.1016/j.jpho....
20.
Rudnicka L, Olszewska M, Rakowska A, et al. Trichoscopy Update 2011. J Dermatol Case Rep. 2011;5(4):82–88. https://doi.org/10.3315/jdcr.2....
21.
Alkeraye S, Alrashidi A, Alotaibi NS, et al. The Association Between Hair Loss and COVID-19: The Impact of Hair Loss After COVID-19 Infection on the Quality of Life Among Residents in Saudi Arabia. Cureus. 2022;14(10):e30266. https://doi.org/10.7759/cureus....
22.
Dhami L. Psychology of Hair Loss Patients and Importance of Counseling. Indian J Plast Surg. 2021;54(04):411–415. https://doi.org/10.1055/s-0041....
23.
Sharquie KE, Jabbar RI. COVID-19 Infection Is a Major Cause of Acute Telogen Effluvium. Ir J Med Sci. 2022;191(4):1677–1681. https://doi.org/10.1007/s11845....
24.
Babaei K, Kavoussi H, Rezaei M, et al. Characteristics of Telogen Effluvium in COVID-19 in Western Iran (2020). An Bras Dermatol. 2021;96(6):688–692. https://doi.org/10.1016/j.abd.....
25.
Chang Y, Bai M, You Q. Associations between Serum Interleukins (IL-1ß, IL-2, IL-4, IL-6, IL-8, and IL-10) and Disease Severity of COVID-19: A Systematic Review and Meta-Analysis. Biomed Res Internat. 2022;2022:2755246. https://doi.org/10.1155/2022/2....
26.
Zanza C, Romenskaya T, Manetti AC, et al. Cytokine Storm in COVID-19: Immunopathogenesis and Therapy. Medicina (Kaunas). 2022;58(2):144. https://doi.org/10.3390/medici....
27.
Ito T, Ito N, Saathoff M, et al. Interferon-Gamma Is a Potent Inducer of Catagen-like Changes in Cultured Human Anagen Hair Follicles. Br J Dermatol. 2005;152(4):623–631. https://doi.org/10.1111/j.1365....
28.
Kwack MH, Ahn, JS, Kim MK, et al. Dihydrotestosterone-Inducible IL-6 Inhibits Elongation of Human Hair Shafts by Suppressing Matrix Cell Proliferation and Promotes Regression of Hair Follicles in Mice. J Invest Dermatol. 2012;132(1):43–49. https://doi.org/10.1038/jid.20....
29.
Kasumagic-Halilovic E, Cavaljuga S, Prohic A. Tumor Necrosis Factor-Alpha in Patients with Alopecia Areata. Indian J Dermatol. 2011;56(5):494. https://doi.org/10.4103/0019-5....
30.
Mandt N, Geilen CC, Wrobel A, et al. Interleukin-4 Induces Apoptosis in Cultured Human Follicular Keratinocytes, but Not in Dermal Papilla Cells. Eur J Dermatol. 2002;12(5):432–438.
31.
English RS. A Hypothetical Pathogenesis Model for Androgenic Alopecia: Clarifying the Dihydrotestosterone Paradox and Rate-Limiting Recovery Factors. Med Hypotheses. 2018;111:73–81. https://doi.org/10.1016/j.mehy....
32.
Tosti A, Piraccini BM, Iorizzo M, et al. The Natural History of Androgenetic Alopecia. J Cosmet Dermatol. 2005;4(1):41–43. https://doi.org/10.1111/j.1473....
33.
Yin JX, Agbana Y L, Sun ZS, et al. Increased Interleukin-6 Is Associated with Long COVID-19: Evidence a Systematic Review and Meta-Analysis. Infect Dis Poverty. 2023;12(1):43. doi:10.1186/s40249-023-01086-z.
34.
Davis HE, McCorkell L, Vogel JM, et al. Long COVID: Major Findings, Mechanisms and Recommendations. Nat Rev Microbiol. 2023;21(3):133–146. https://doi.org/10.1038/s41579....
35.
Queiroz MAF, Neves P FM, das, Lima SS, et al. Cytokine Profiles Associated With Acute COVID-19 and Long COVID-19 Syndrome. Front Cell Infect Microbiol. 2022;12:922422. https://doi.org/10.3389/fcimb.....
36.
Rebora A, Guarrera M, Baldari M, et al. Distinguishing Androgenetic Alopecia From Chronic Telogen Effluvium When Associated in the Same Patient: A Simple Noninvasive Method. Arch Dermatol. 2005;141(10). https://doi.org/10.1001/archde....
37.
Rebora A. Telogen Effluvium: A Comprehensive Review. Clin Cosmet Investig Dermatol. 2019;12:583–590. https://doi.org/10.2147/CCID.S....
38.
Han L, Liu B, Chen X, et al. Activation of Wnt/ß-Catenin Signaling Is Involved in Hair Growth-Promoting Effect of 655-Nm Red Light and LED in in Vitro Culture Model. Lasers Med Sci. 2018;33(3):637–645. https://doi.org/10.1007/s10103....
39.
Suchonwanit P, Chalermroj N, Khunkhet S. Low-Level Laser Therapy for the Treatment of Androgenetic Alopecia in Thai Men and Women: A 24-Week, Randomized, Double-Blind, Sham Device-Controlled Trial. Lasers Med Sci. 2019;34(6):1107–1114. https://doi.org/10.1007/s10103....
40.
Fonda-Pascual P, Moreno-Arrones OM, Saceda-Corralo D, et. al. Effectiveness of Low-Level Laser Therapy in Lichen Planopilaris. J Am Acad Dermatol. 2018;78(5):1020–1023. https://doi.org/10.1016/j.jaad....
41.
Egger A, Resnik SR, Aickara D, et al. Examining the Safety and Efficacy of Low-Level Laser Therapy for Male and Female Pattern Hair Loss: A Review of the Literature. Skin Appendage Disord. 2020;6(5):259–267. https://doi.org/10.1159/000509....
42.
Amer M, Nassar A, Attallah H, et al. Results of Low-level Laser Therapy in the Treatment of Hair Growth: An Egyptian Experience. Dermatol Ther. 2021;34(3):e14940. https://doi.org/10.1111/dth.14....
43.
Kato H, Kinoshita K, Saito N, et al. The Effects of Ischemia and Hyperoxygenation on Hair Growth and Cycle. Organogenesis 2020;16(3):83–94. https://doi.org/10.1080/154762....
44.
Zarei M, Wikramanayake TC, Falto-Aizpurua L, et al. Low Level Laser Therapy and Hair Regrowth: An Evidence-Based Review. Lasers Med Sci. 2016;31(2):363–371. https://doi.org/10.1007/s10103....
45.
Starace M, Iorizzo M, Sechi A, et al. Trichodynia and Telogen Effluvium in COVID-19 Patients: Results of an International Expert Opinion Survey on Diagnosis and Management. JAAD Int. 2021;5:11–18. https://doi.org/10.1016/j.jdin....
46.
Ericson M, Gabrielson A, Worel S, et al. Substance P (SP) in Innervated and Non-Innervated Blood Vessels in the Skin of Patients with Symptomatic Scalp. Exp Dermatol. 1999;8(4):344–345.
47.
Kim C, Shin JM, Kim D, et al. Role of Substance P in Regulating Micro-Milieu of Inflammation in Alopecia Areata. Ann Dermatol. 2022;34(4):270. https://doi.org/10.5021/ad.21.....
48.
Doganay Yildiz E, Arslan H, Köseoglu S, et al. The Effect of Photobiomodulation on Total Amount of Substance P in Gingival Crevicular Fluid: Placebo-Controlled Randomized Clinical Trial. Lasers Med Sci. 2019;34(3):517–523. https://doi.org/10.1007/s10103....
49.
Kunarti S, Eka Juniarti D, Kartini Sunur Y, et al. The Different Effects of Low-Level Laser Therapy before and after Overinstrumentation on the Expression of Substance P and Interleukin-10. Saudi Dental J. 2023;35(4):317–321. https://doi.org/10.1016/j.sden....
50.
Han DS, Lee CH, Shieh YD, et al. Involvement of Substance P in the Analgesic Effect of Low-Level Laser Therapy in a Mouse Model of Chronic Widespread Muscle Pain. Pain Med. 2019;20(10):1963–1970. https://doi.org/10.1093/pm/pnz....
51.
Ward IL, Bermingham C, Ayoubkhani D, et al. Risk of Covid-19 Related Deaths for SARS-CoV-2 Omicron (B.1.1.529) Compared with Delta (B.1.617.2): Retrospective Cohort Study. BMJ. 2022;378:e070695. https://doi.org/10.1136/bmj-20....
52.
Seyfi S, Alijanpour R, Aryanian Z, et al. Prevalence of Telogen Effluvium Hair Loss in COVID-19 Patients and Its Relationship with Disease Severity. J Med Life. 2022;15(5):631–634. https://doi.org/10.25122/jml-2....
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