REVIEW PAPER
Magnetic resonance spectroscopy as a promising modality for assessing ketogenic diet impact on the level of cerebral metabolites in the treatment of certain neurological disorders
1
Chair and Department of Epidemiology and Clinical Research Methodology, Medical University, Lublin, Poland
Corresponding author
Piotr Artur Machowiec
hair and Department of Epidemiology and Clinical Research Methodology, Medical University, Lublin, Poland
hair and Department of Epidemiology and Clinical Research Methodology, Medical University, Lublin, Poland
Ann Agric Environ Med. 2022;29(2):201-206
KEYWORDS
TOPICS
Prevention of occupational diseases in agriculture, forestry, food industry and wood industryState of the health of rural communities depending on various factors: social factors, accessibility of medical care, etc.
ABSTRACT
Introduction and objective:
The ketogenic diet (KD) is a high-fat, adequate-protein, low-carbohydrate diet that is getting more and more widespread in medicine. This dietary intervention causes changes in cerebral metabolism, which are considered potentially beneficial in patients with neurological disorders, but its impact should be controlled and assessed individually. The aim of this review is to provide an update of existing evidence concerning the utility of magnetic resonance spectroscopy (MRS) in monitoring shifts in the cerebral metabolism during ketogenic diet in patients with neurological disorders
Review methods:
The latest available literature was reviewed by May 13, 2021 using the PubMed, Web of Science and Google Scholar databases. There were 13 papers selected for analysis after reading the title, abstracts and whole text, meeting the assumed criteria.
Abbreviated description of the state of knowledge:
MRS is a non-invasive imaging method providing information about the metabolism of brain tissues and playing an increasingly important role in monitoring the concentrations of cerebral metabolites in the course of such neurological disorders as primary brain tumour, epilepsy during KD. Recent trials prove that inverse correlation between serum β-hydroxybutyrate levels and N-acetylaspartate in brain tissue confirm antiepileptogenic properties of KD. Furthermore, ketone concentrations including β-hydroxybutyrate and acetone in both lesional and contralateral brain are referred to as correlating with average ketonuria in patients with primary brain tumou
Summary:
MRS is a feasible tool for detecting cerebral metabolic shifts linked to a ketogenic diet. However, further studies confirming MR spectroscopy utility in monitoring ketogenic diet treatment in patients with neurological disorders are needed
The ketogenic diet (KD) is a high-fat, adequate-protein, low-carbohydrate diet that is getting more and more widespread in medicine. This dietary intervention causes changes in cerebral metabolism, which are considered potentially beneficial in patients with neurological disorders, but its impact should be controlled and assessed individually. The aim of this review is to provide an update of existing evidence concerning the utility of magnetic resonance spectroscopy (MRS) in monitoring shifts in the cerebral metabolism during ketogenic diet in patients with neurological disorders
Review methods:
The latest available literature was reviewed by May 13, 2021 using the PubMed, Web of Science and Google Scholar databases. There were 13 papers selected for analysis after reading the title, abstracts and whole text, meeting the assumed criteria.
Abbreviated description of the state of knowledge:
MRS is a non-invasive imaging method providing information about the metabolism of brain tissues and playing an increasingly important role in monitoring the concentrations of cerebral metabolites in the course of such neurological disorders as primary brain tumour, epilepsy during KD. Recent trials prove that inverse correlation between serum β-hydroxybutyrate levels and N-acetylaspartate in brain tissue confirm antiepileptogenic properties of KD. Furthermore, ketone concentrations including β-hydroxybutyrate and acetone in both lesional and contralateral brain are referred to as correlating with average ketonuria in patients with primary brain tumou
Summary:
MRS is a feasible tool for detecting cerebral metabolic shifts linked to a ketogenic diet. However, further studies confirming MR spectroscopy utility in monitoring ketogenic diet treatment in patients with neurological disorders are needed
REFERENCES (26)
1.
Murphy EA, Jenkins TJ. A ketogenic diet for reducing obesity and maintaining capacity for physical activity: hype or hope? Curr Opin Clin Nutr Metab Care. 2019 Jul; 22(4): 314–319. https://doi.org/ 10.1097/ MCO.0000000000000572.
2.
Moreno B, Crujeiras AB, Bellido D, et al. Obesity treatment by very low-calorie-ketogenic diet at two years: reduction in visceral fat and on the burden of disease. Endocrine. 2016; 54(3): 681–690. https://doi. org/10.1007/s12020-016-1050-2.
3.
Bruci A, Tuccinardi D, Tozzi R, et al. Very Low-Calorie Ketogenic Diet: A Safe and Effective Tool for Weight Loss in Patients With Obesity and Mild Kidney Failure. Nutrients. 2020; 12(2): 333. Published 2020 Jan 27. https://doi.org/10.3390/nu1202....
4.
Lambrechts DA, de Kinderen RJ, Vles JS, et al. A randomized controlled trial of the ketogenic diet in refractory childhood epilepsy. Acta Neurol Scand. 2017; 135(2): 231–239. https://doi.org/10.1111/ane.12....
5.
Baby N, Vinayan KP, Pavithran N, et al. A pragmatic study on efficacy, tolerability and long term acceptance of ketogenic diet therapy in 74 South Indian children with pharmacoresistant epilepsy. Seizure. 2018; 58: 41–46. https://doi.org/10.1016/j.seiz....
6.
Ashrafi MR, Hosseini SA, Zamani GR, et al. The efficacy of the ketogenic diet in infants and young children with refractory epilepsies using a formula-based powder. Acta Neurol Belg. 2017; 117(1): 175–182. https:// doi.org/10.1007/s13760-016-0732-0.
7.
Kverneland M, Molteberg E, Iversen PO, et al. Effect of modified Atkins diet in adults with drug-resistant focal epilepsy: A randomized clinical trial. Epilepsia. 2018; 59(8): 1567–1576. https://doi.org/10.1111/epi.14....
8.
Gzieło K, Janeczko K, Węglarz W, et al. MRI spectroscopic and tractography studies indicate consequences of long-term ketogenic diet. Brain Struct Funct. 2020; 225(7): 2077–2089. https://doi.org/10.1007/ s00429020-02111-9.
9.
Voss M, Wagner M, von Mettenheim N, et al. ERGO2: A Prospective, Randomized Trial of Calorie-Restricted Ketogenic Diet and Fasting in Addition to Reirradiation for Malignant Glioma. Int J Radiat Oncol Biol Phys. 2020; 108(4): 987–995. https.//doi.org/10.1016/j.ijrobp.2020.06.021.
10.
Cohen CW, Fontaine KR, Arend RC, et al. Favorable Effects of a Ketogenic Diet on Physical Function, Perceived Energy, and Food Cravings in Women with Ovarian or Endometrial Cancer: A Randomized, Controlled Trial. Nutrients. 2018; 10(9): 1187. Published 2018 Aug 30. https://doi.org/10.3390/nu1009....
11.
Cohen CW, Fontaine KR, Arend RC, et al. A Ketogenic Diet Reduces Central Obesity and Serum Insulin in Women with Ovarian or Endometrial Cancer. J Nutr. 2018; 148(8): 1253–1260. https://doi. org/10.1093/jn/nxy119.
12.
Khodabakhshi A, Akbari ME, Mirzaei HR, et al. Feasibility, Safety, and Beneficial Effects of MCT-Based Ketogenic Diet for Breast Cancer Treatment: A Randomized Controlled Trial Study. Nutr Cancer. 2020; 72(4): 627–634. https://doi.org/10.1080/016355....
13.
Zahra A, Fath MA, Opat E, et al. Consuming a Ketogenic Diet while Receiving Radiation and Chemotherapy for Locally Advanced Lung Cancer and Pancreatic Cancer: The University of Iowa Experience of Two Phase 1 Clinical Trials. Radiat Res. 2017; 187(6): 743–754. https:// doi.org/10.1667/RR14668.1.
14.
Lee P, Adany P, Choi IY. Imaging based magnetic resonance spectroscopy (MRS) localization for quantitative neurochemical analysis and cerebral metabolism studies. Anal Biochem. 2017; 529: 40–47. https://doi.org/10.1016/j.ab.2....
15.
Emir UE, Auerbach EJ, Van De Moortele PF, et al. Regional neurochemical profiles in the human brain measured by ¹H MRS at 7 T using local B₁ shimming. NMR Biomed. 2012; 25(1): 152–160. https:// doi.org/10.1002/nbm.1727.
16.
Setkowicz Z, Gaździńska A, Osoba JJ, et al. Does Long-Term High Fat Diet Always Lead to Smaller Hippocampi Volumes, Metabolite Concentrations, and Worse Learning and Memory? A Magnetic Resonance and Behavioral Study in Wistar Rats. PLoS One. 2015; 10(10): e0139987. Published 2015 Oct 8. https://doi.org/10.1371/journa.... pone.0139987.
17.
Berrington A, Schreck KC, Barron BJ, et al. Cerebral Ketones Detected by 3T MR Spectroscopy in Patients with High-Grade Glioma on an Atkins-Based Diet. AJNR Am J Neuroradiol. 2019; 40(11): 1908–1915. https://doi.org/10.3174/ajnr.A....
18.
Artzi M, Liberman G, Vaisman N, et al. Changes in cerebral metabolism during ketogenic diet in patients with primary brain tumors: 1H-MRS study. J Neurooncol. 2017; 132(2): 267–275. https.//doi.org/10.1007/ s11060-016-2364-x.
19.
Schreck KC, Hsu FC, Berrington A, et al. Feasibility and Biological Activity of a Ketogenic/Intermittent-Fasting Diet in Patients With Glioma [published online ahead of print, 2021 Jul 7]. Neurology. 2021; 10.1212/WNL.0000000000012386. https://doi.org/10.1212/ WNL.0000000000012386.
20.
Ciusani E, Vasco C, Rizzo A, et al. MR-Spectroscopy and Survival in Mice with High Grade Glioma Undergoing Unrestricted Ketogenic Diet [published online ahead of print, 2020 Sep 21]. Nutr Cancer. 2020; 1–8. https://doi.org/10.1080/016355....
21.
Napolitano A, Longo D, Lucignani M, et al. The Ketogenic Diet Increases In Vivo Glutathione Levels in Patients with Epilepsy. Metabolites. 2020; 10(12): 504. Published 2020 Dec 10. https.//doi.org/10.3390/ metabo10120504.
22.
Wright JN, Saneto RP, Friedman SD. β-Hydroxybutyrate Detection with Proton MR Spectroscopy in Children with Drug-Resistant Epilepsy on the Ketogenic Diet. AJNR Am J Neuroradiol. 2018; 39(7): 1336–1340. https.//doi.org/10.3174/ajnr.A5648.
23.
Yum MS, Lee M, Woo DC, et al. β-Hydroxybutyrate attenuates NMDA- induced spasms in rats with evidence of neuronal stabilization on MR spectroscopy. Epilepsy Res. 2015; 117: 125–132. https.//doi.org/10.1016/j. eplepsyres.2015.08.005.
24.
Mu C, Corley MJ, Lee RWY, et al. Metabolic Framework for the Improvement of Autism Spectrum Disorders by a Modified Ketogenic Diet: A Pilot Study. J Proteome Res. 2020; 19(1): 382–390. https.//doi. org/10.1021/acs.jproteome.9b00581.
25.
Lee SK, Kim J, Kim HD, et al. Initial experiences with proton MR spectroscopy in treatment monitoring of mitochondrial encephalopathy. Yonsei Med J. 2011; 51(5): 672–675. https.//doi. org/10.3349/ymj.2010.51.5.672.
26.
Zhang F, Wu H, Jin Y, et al. Proton Magnetic Resonance Spectroscopy (H1-MRS) Study of the Ketogenic Diet on Repetitive Mild Traumatic Brain Injury in Adolescent Rats and Its Effect on Neurodegeneration. World Neurosurg. 2018; 120: e1193-e1202. https.//doi.org/10.1016/j. wneu.2018.09.037.
| eISSN: | 1898-2263 |
| ISSN: | 1232-1966 |
Improvement of visual identification of the journal - task financed under the agreement No. 618/P-DUN/2019 by the Minister of Science and Higher Education allocated to the activities of disseminating science.
Generation of the DOI (Digital Object Identifier) - task financed under the agreement No. 618/P-DUN/2019 by the Minister of Science and Higher
© 2006-2024 Journal hosting platform by Bentus
We process personal data collected when visiting the website. The function of obtaining information about users and their behavior is carried out by voluntarily entered information in forms and saving cookies in end devices. Data, including cookies, are used to provide services, improve the user experience and to analyze the traffic in accordance with the Privacy policy. Data are also collected and processed by Google Analytics tool (more).
You can change cookies settings in your browser. Restricted use of cookies in the browser configuration may affect some functionalities of the website.
You can change cookies settings in your browser. Restricted use of cookies in the browser configuration may affect some functionalities of the website.
