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1/2024 vol. 31
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Iron deficiency, iron deficiency anaemia and anaemia of inflammation – an overview
Beata Kulik-Rechberger 1
,
 
Magdalena Dubel 1
 
 
 
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1
Department of Paediatric Propedeutics, Medical University, Lublin, Poland
 
 
Corresponding author
Beata Kulik-Rechberger   

Medical University of Lublin, Department of Paediatric Propedeutics, Lublin, Poland
 
 
Ann Agric Environ Med. 2024;31(1):151-157
DOI: https://doi.org/10.26444/aaem/171121
 
 
Article (PDF)
References (59)
 
KEYWORDS
inflammation
iron
anaemia
 
TOPICS
State of the health of rural communities depending on various factors: social factors, accessibility of medical care, etc.
 
ABSTRACT
Iron is an essential trace element for various cellular proteins and for biological processes in all cells. Severe iron deficiency (ID) impairs haem synthesis, reduces erythropoiesis and causes iron deficiency anaemia (IDA). Iron restriction in anaemia of inflammation is mainly due to retention of iron in macrophages. This condition is known as ‘functional iron deficiency’. A review of studies performed in Europe shows that the prevalence of ID and IDA in young children varies by region. It is more common in eastern than western European countries. This overview summarises information on the need for iron supplementation in children, and the current understanding of the regulatory mechanisms of iron homeostasis and ironrestricted erythropoiesis. The causes of anaemia during infection and the usefulness of classical and new indicators to distinguish absolute from functional iron deficiency are discussed.
 
REFERENCES (59)
1.
Janbek J, Sarki M, Specht IO, et al. A systematic literature review of the relation between iron status/anemia in pregnancy and offspring neurodevelopment. Eur J Clin Nutr. 2019;73(12):1561–1578.
Google Scholar
 
 
2.
Gattermann N, Muckenthaler MU, Kulozik AE, et al. The Evaluation of Iron Deficiency and Iron Overload. Dtsch Arztebl Int. 2021;118(49):847–856.
CrossRef
 
Google Scholar
 
 
3.
McCann S, Perapoch Amadó M, Moore SE. The Role of Iron in Brain Development: A Systematic Review. Nutrients. 2020;12(7):2001.
CrossRef
 
Google Scholar
 
 
4.
Wiegersma AM, Dalman C, Lee BK, et al. Association of Prenatal Maternal Anemia With Neurodevelopmental Disorders. JAMA Psychiatry. 2019;76(12):1294–1304.
Google Scholar
 
 
5.
Means RT. Iron Deficiency and Iron Deficiency Anemia: Implications and Impact in Pregnancy, Fetal Development, and Early Childhood Parameters. Nutrients. 2020;12(2):447.
Google Scholar
 
 
6.
World Health Organization. (2022). WHO Global anemia estimates, 2021 Edition. Global anemia estimates in women of reproductive age, by pregnancy status, and in children aged 6–59 months. https://www.who.int/data/gho/d....
Google Scholar
 
 
7.
Christian P, Smith ER. Adolescent Undernutrition: Global Burden, Physiology, and Nutritional Risks. Ann Nutr Metab. 2018;72(4):316–328.
Google Scholar
 
 
8.
Shao J, Lou J, Rao R, et al. Maternal serum ferritin concentration is positively associated with newborn iron stores in women with low ferritin status in late pregnancy. J Nutr. 2012;142(11):2004–2009.
Google Scholar
 
 
9.
van der Merwe LF, Eussen SR. Iron status of young children in Europe. Am J Clin Nutr. 2017;106 (Suppl 6):1663S–1671S.
Google Scholar
 
 
10.
Gupta PM, Perrine CG, Mei Z, et al. Iron, Anemia, and Iron Deficiency Anemia among Young Children in the United States Nutrients 2016, 8, 330. Nutrients. 2017;9(8):876.
Google Scholar
 
 
11.
Gedfie S, Getawa S, Melku M. Prevalence and Associated Factors of Iron Deficiency and Iron Deficiency Anemia Among Under-5 Children: A Systematic Review and Meta-Analysis. Glob Pediatr Health. 2022;9:2333794X221110860.
Google Scholar
 
 
12.
Tang D, Chen X, Kang R, et al. Ferroptosis: molecular mechanisms and health implications. Cell Res. 2021;31(2):107–125.
Google Scholar
 
 
13.
Zhang DL, Ghosh MC, Rouault TA. The physiological functions of iron regulatory proteins in iron homeostasis – an update. Front Pharmacol. 2014;5:124.
Google Scholar
 
 
14.
Galetti V, Stoffel NU, Sieber C, et al. Threshold ferritin and hepcidin concentrations indicating early iron deficiency in young women based on upregulation of iron absorption. EClinicalMedicine. 2021;39:101052.
Google Scholar
 
 
15.
DeLoughery TG. Iron deficiency anemia. Med Clin North Am. 2017;101(2):319–32.
Google Scholar
 
 
16.
Anderson GJ, Frazer DM. Current understanding of iron homeostasis. Am J Clin Nutr. 2017;106(Suppl 6):1559S–1566S. doi:10.3945/ajcn.117.155804.
CrossRef
 
Google Scholar
 
 
17.
Chen JJ. Regulation of protein synthesis by the heme-regulated eIF2alpha kinase: relevance to anemias. Blood. 2007;109(7):2693–2699.
Google Scholar
 
 
18.
Powers JM, Buchanan GR. Disorders of Iron Metabolism: New Diagnostic and Treatment Approaches to Iron Deficiency. Hematol Oncol Clin North Am. 2019;33(3):393–408.
Google Scholar
 
 
19.
Chaber R. Jak wstępnie w 4 krokach zdiagnozować niedokrwistość u dziecka – kompendium dla lekarzy POZ Standardy Medyczne/Pediatria 2023. Vol. 20:41–51.
Google Scholar
 
 
20.
Gallagher PG. Anemia in the pediatric patient. Blood. 2022;140(6):571–593.
Google Scholar
 
 
21.
Munro MG, Mast AE, Powers JM, et al. The relationship between heavy menstrual bleeding, iron deficiency, and iron deficiency anemia. Am J Obstet Gynecol. 2023;S0002–9378(23)00024–8.
Google Scholar
 
 
22.
Abioye AI, McDonald EA, Park S, et al. Maternal anemia type during pregnancy is associated with anemia risk among offspring during infancy. Pediatr Res. 2019;86(3):396–402.
Google Scholar
 
 
23.
Camaschella C. Iron deficiency [published correction appears in Blood. 2023 Feb 9;141(6):682]. Blood. 2019;133(1):30–39.
Google Scholar
 
 
24.
Fisher AL, Nemeth E. Iron homeostasis during pregnancy. Am J Clin Nutr. 2017;106(Suppl 6):1567S–1574S.
Google Scholar
 
 
25.
Donker AE, van der Staaij H, Swinkels DW. The critical roles of iron during the journey from fetus to adolescent: Developmental aspects of iron homeostasis. Blood Rev. 2021;50:100866.
Google Scholar
 
 
26.
Davidson EM, Simpson JA, Fowkes FJI. The interplay between maternal-infant anemia and iron deficiency. Nutr Rev. 2023;81(4):480–491.
Google Scholar
 
 
27.
Mattiello V, Schmugge M, Hengartner H, et al. Diagnosis and management of iron deficiency in children with or without anemia: consensus recommendations of the SPOG Pediatric Hematology Working Group. Eur J Pediatr. 2020;179(4):527–545.
Google Scholar
 
 
28.
National Institutes of Health Office of Dietary Supplements: Iron Fact Sheet for Health Professionals Accessed 9/2/2019.
Google Scholar
 
 
29.
Muckenthaler MU, Rivella S, Hentze MW, et al. A Red Carpet for Iron Metabolism. Cell. 2017;168(3):344–361.
Google Scholar
 
 
30.
Fewtrell M, Bronsky J, Campoy C, et al. Complementary Feeding: A Position Paper by the European Society for Paediatric Gastroenterology, Hepatology, and Nutrition (ESPGHAN) Committee on Nutrition. J Pediatr Gastroenterol Nutr. 2017;64(1):119–132.
Google Scholar
 
 
31.
EFSA Panel on Dietetic Products Nutrition and Allergies. Scientific opinion on dietary reference values for iron. EFSA J 2015;13:4254.
Google Scholar
 
 
32.
Lauterbach R. Homeostaza żelaza – zapobieganie niedoborowi we wczesnym okresie rozwoju. In: Standardy Opieki Medycznej nad Noworodkiem w Polsce – zalecenia Polskiego Towarzystwa Neonatologicznego. 4th ed. Warszawa: Media-Press Sp. z o.o.; 2021. p. 471–475.
Google Scholar
 
 
33.
Domellöf M, Braegger C, Campoy C, et al. Iron requirements of infants and toddlers. J Pediatr Gastroenterol Nutr. 2014;58(1):119–129.
CrossRef
 
Google Scholar
 
 
34.
World Health Organization. Daily iron supplementation in infants and children Guideline. Geneva: World Health Organization; 2016.
Google Scholar
 
 
35.
Nairz M, Theurl I, Wolf D, et al. Iron deficiency or anemia of inflammation?: Differential diagnosis and mechanisms of anemia of inflammation. Eisenmangel oder Entzündungsanämie?: Differenzialdiagnose und Mechanismen der Entzündungsanämie. Wien Med Wochenschr. 2016;166(13–14):411–423.
CrossRef
 
Google Scholar
 
 
36.
Weiss G, Ganz T, Goodnough LT. Anemia of inflammation. Blood. 2019;133(1):40–50.
CrossRef
 
Google Scholar
 
 
37.
Nemeth E, Rivera S, Gabayan V, et al. IL-6 mediates hypoferremia of inflammation by inducing the synthesis of the iron regulatory hormone hepcidin. J Clin Invest. 2004;113(9):1271–1276.
CrossRef
 
Google Scholar
 
 
38.
Marques O, Weiss G, Muckenthaler MU. The role of iron in chronic inflammatory diseases: from mechanisms to treatment options in anemia of inflammation. Blood. 2022;140(19):2011–2023.
CrossRef
 
Google Scholar
 
 
39.
Bergamaschi G, Borrelli de Andreis F, Aronico N, et al. Anemia in patients with Covid-19: pathogenesis and clinical significance [published correction appears in Clin Exp Med. 2021;21(2):239–246.
Google Scholar
 
 
40.
Ganz T, Nemeth E. Iron sequestration and anemia of inflammation. Semin Hematol. 2009;46:387–393.
CrossRef
 
Google Scholar
 
 
41.
Abbas M, Hayirli Z, Drakesmith H, et al. Effects of iron deficiency and iron supplementation at the host-microbiota interface: Could a piglet model unravel complexities of the underlying mechanisms? Front Nutr. 2022;9:927754.
CrossRef
 
Google Scholar
 
 
42.
Hess SY, Owais A, Jefferds MED, et al. Accelerating action to reduce anemia: Review of causes and risk factors and related data needs. Ann N Y Acad Sci. 2023;1523(1):11–23.
Google Scholar
 
 
43.
Tanous O, Levin C, Suchdev PS, et al. Resolution of iron deficiency following successful eradication of Helicobacter pylori in children. Acta Paediatr. 2022;111(5):1075–1082.
CrossRef
 
Google Scholar
 
 
44.
Pasricha SR, Tye-Din J, Muckenthaler MU, et al. Iron deficiency. Lancet. 2021;397(10270):233–248.
Google Scholar
 
 
45.
Kumar SB, Arnipalli SR, Mehta P, et al. Iron Deficiency Anemia: Efficacy and Limitations of Nutritional and Comprehensive Mitigation Strategies. Nutrients. 2022;14(14):2976.
CrossRef
 
Google Scholar
 
 
46.
Cappellini MD, Motta I. Anemia in Clinical Practice-Definition and Classification: Does Hemoglobin Change With Aging?. Semin Hematol. 2015;52(4):261–269.
CrossRef
 
Google Scholar
 
 
47.
WHO, UNICEF, UNU: Iron deficiency anemia: assessment, prevention, and control: a guide for programme managers. Geneva: World Health Organization; 2001. WHO/ NHD/01.3.
Google Scholar
 
 
48.
WHO. WHO guideline on use of ferritin concentrations to assess iron status in individuals and populations. 2020. https://www.who.int/publicatio... (accessed Nov 14, 2020).
Google Scholar
 
 
49.
Camaschella C. Iron-deficiency anemia. N Engl J Med. 2015;372(19): 1832–1843.
CrossRef
 
Google Scholar
 
 
50.
Dignass A, Farrag K, Stein J. Limitations of Serum Ferritin in Diagnosing Iron Deficiency in Inflammatory Conditions. Int J Chronic Dis. 2018;2018:9394060.
Google Scholar
 
 
51.
Baker RD, Greer FR; Committee on Nutrition American Academy of Pediatrics. Diagnosis and prevention of iron deficiency and iron-deficiency anemia in infants and young children (0–3 years of age). Pediatrics. 2010;126(5):1040–1050.
CrossRef
 
Google Scholar
 
 
52.
Mukhtarova N, Ha B, Diamond CA, et al. Serum Ferritin Threshold for Iron Deficiency Screening in One-Year-Old Children. J Pediatr. 2022;245:217–221.
CrossRef
 
Google Scholar
 
 
53.
Gelaw Y, Woldu B, Melku M. The Role of Reticulocyte Hemoglobin Content for Diagnosis of Iron Deficiency and Iron Deficiency Anemia, and Monitoring of Iron Therapy: a Literature Review. Clin Lab. 2019;65(12):10.7754/Clin.Lab.2019.190315.
CrossRef
 
Google Scholar
 
 
54.
Ogawa C, Tsuchiya K, Maeda K. Reticulocyte hemoglobin content. Clin Chim Acta. 2020 May;504:138–145.
Google Scholar
 
 
55.
Soldin OP, Miller M, Soldin SJ. Pediatric reference ranges for zinc protoporphyrin. Clin Biochem. 2003;36(1):21–5.
CrossRef
 
Google Scholar
 
 
56.
Rohner F, Namaste SM, Larson LM, et al. Adjusting soluble transferrin receptor concentrations for inflammation: Biomarkers Reflecting Inflammation and Nutritional Determinants of Anemia (BRINDA) project. Am J Clin Nutr. 2017;106(Suppl 1):372S–382S.
CrossRef
 
Google Scholar
 
 
57.
Bhatia P, Siyaram D, Deepshikha, et al. Lower Plasma Soluble Transferrin Receptor Range in Healthy Indian Pediatric Cohort as Compared to Asian and Western Data. Indian J Hematol Blood Transfus. 2017;33(3):405–407.
Google Scholar
 
 
58.
Pagani A, Nai A, Silvestri L, Camaschella C. Hepcidin and Anemia: A Tight Relationship. Front Physiol. 2019;10:1294.
CrossRef
 
Google Scholar
 
 
59.
Au TY, Benjamin S, Wiśniewski OW. Is the Role of Hepcidin and Erythroferrone in the Pathogenesis of Beta Thalassemia the Key to Developing Novel Treatment Strategies? Thalass Rep. 2022, 12, 123–134.
Google Scholar
 
 
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