RESEARCH PAPER
Differences in the expression of selected genes associated with cell stress response in a PTSD patient and in healthy individuals – a case study
| 1 | Institute of Psychology, Kazimierz Wielki University, Bydgoszcz, Poland |
| 2 | Faculty of Medicine and Health Sciences, Jan Kochanowski University in Kielce, Kielce, Poland |
| 3 | The Old Polish University, Kielce, Poland |
| 4 | Department of Life Sciences, Gdańsk University of Physical Education and Sport, Gdańsk, Poland |
| 5 | Chair of Neuropsychology, The Andrzej Frycz-Modrzewski Cracow University, Kraków, Poland |
| 6 | The Department of Physiotherapy, Academy of Physical Education, Katowice, Poland |
Ann Agric Environ Med. 2017;24(2):332–337
KEYWORDS
ABSTRACT
Objective:
The aim of the study was determination of the level in expression genes associated with cell stress response in a patient with PTSD.
Case study:
A 57-year-old PTSD patient, A.P., was the subject of the study. Blood samples were taken from the ulnar vein to assess the relative expression of the tested genes in leukocytes via a quantitative reverse transcription polymerase chain reaction (qRT-PCR).
Results:
A considerably decreased level in the expression HSF-1, NF-kB, Hif-1 and IL6 m-RNA was observed in the patient when compared to the control group. A low expression in HSPA1A, HSPB1, IL10 and CRP m-RNA compared with the control group was also noted.
Conclusions:
It is possible that the lower level of transcriptional factors: HSF-1, NF-kB and Hif-1 as well as IL6 m-RNA may be associated with the effect of the PTSD patient’s treatment.
The aim of the study was determination of the level in expression genes associated with cell stress response in a patient with PTSD.
Case study:
A 57-year-old PTSD patient, A.P., was the subject of the study. Blood samples were taken from the ulnar vein to assess the relative expression of the tested genes in leukocytes via a quantitative reverse transcription polymerase chain reaction (qRT-PCR).
Results:
A considerably decreased level in the expression HSF-1, NF-kB, Hif-1 and IL6 m-RNA was observed in the patient when compared to the control group. A low expression in HSPA1A, HSPB1, IL10 and CRP m-RNA compared with the control group was also noted.
Conclusions:
It is possible that the lower level of transcriptional factors: HSF-1, NF-kB and Hif-1 as well as IL6 m-RNA may be associated with the effect of the PTSD patient’s treatment.
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Improvement of visual identification of the journal - task financed under the agreement No. 618/P-DUN/2019 by the Minister of Science and Higher Education allocated to the activities of disseminating science.
Generation of the DOI (Digital Object Identifier) - task financed under the agreement No. 618/P-DUN/2019 by the Minister of Science and Higher
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