Dermal absorption and distribution of 14C carbaryl in Wistar rats.
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Department of Pathomorphology, Institute of Agricultural Medicine, Lublin, Poland
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Sabina Tos-Luty
Department of Pathomorphology, Institute of Agricultural Medicine, Lublin, Poland
Ann Agric Environ Med. 2001;8(1):47-50
The level of 14C carbaryl was determined in blood (leukocytes, erythrocytes, all blood cells, plasma) and organs (brain, heart, lungs, liver, spleen, skin at the site of exposure) of male Wistar rats after dermal administration. The application liquid was 14C carbaryl solution in 96% ethyl alcohol. This preparation, possessing an activity of 670 kBq/ml, containing 1.67 mg of carbaryl, was applied to the skin of the tail according to Massmann's method in own modification. The amount of the preparation per 1 cm2 of the tail skin was 0.19 mg of carbaryl (74.4 kBq). The tails of experimental rats were exposed to 14C carbaryl by soaking for 4 h daily: once, twice or three times. Beta radiation from 14C was measured in homogenized organs (brain, heart, lungs, liver, skin) and in blood by computer controlled Wallac scintillation counter Model 1409, using Multi Calc software. The dermal absorption of carbaryl at the site of exposure and in the surrounding area of about 2 cm was observed already during 4 hour exposure. Carbaryl reached plasma within 4 h of a single dermal exposure and penetrated into leukocytes, erythrocytes, heart, liver, lung, kidney and brain. The largest amount of 14C carbaryl, about 2% of absorbed dose, was detected in liver
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