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RESEARCH PAPER
 
CC BY-NC-ND 3.0
 
 

Urinary 1-hydroxypyrene in occupationally-exposed and non-exposed individuals in Silesia, Poland

Joanna Zając 1  ,  
Ewa Gomółka 2, 3,  
 
1
Jagiellonian University Medical College, Dep. Hygiene and Dietetics
2
Toxicological Laboratory, Diagnostics Department, University Hospital, Kraków, Poland
3
Laboratory of Poison Information and Toxicological Analysis, Department of Toxicology and Environmental Disease, Jagiellonian University Medical College, Kraków, Poland
KEYWORDS:
TOPICS:
ABSTRACT:
Introduction:
The aim of presented study was comparison of urinary 1-hydroxypyrene concentration among coke plant workers (before and after working week) and among non-exposed individuals from the same area, taking smoking status into consideration.

Material and methods:
647 coke plant workers and 206 individuals living in the same area were analysed with respect to urinary 1-OHP concentration and smoking status. Urinary samples were measured using high performance liquid chromatography (HPLC) with fluorescent detection. Concentrations were normalized with respect to creatinine concentration. For workers, two samples were collected before and after working week. Multiple regression was performed to distinguish and quantify the influence of cigarette smoking and occupational PAH exposition on the urinary 1-OHP levels.

Results:
Average urinary 1-OHP concentration of samples collected before the working week was: 1.07 μg/g; after the working week: 2.36 μg/g and for control: 0.74 μg/g. The samples collected at the beginning of the working week were not suitable for assessment of the workers’ background (non-occupational) exposition. Smoking cigarettes induced a rise in urinary 1-OHP level by 16%, on average (CI: 5% – 28%), and working for a whole working week at the coke plant made urinary 1-OHP levels, on average, 3.21 times higher (CI: 2.91 – 3.54).

Conclusions:
Working at the coke plant increases significantly urinary 1-OHP concentration in comparison to non-occupationally exposed individuals, both for samples collected before and after the working week. Smoking remains a significant source of PAHs exposition, despite the fact that occupational exposure is greater. Health promotion programmes should address both the occupational health risks reduction and smoking prevention.

CORRESPONDING AUTHOR:
Joanna Zając   
Jagiellonian University Medical College, Department Hygiene and Dietetics, Kraków, Poland
 
REFERENCES (27):
1. Samanta SK, Singh OV, Jain RK. Polycyclic aromatic hydrocarbons: environmental pollution and bioremediation. Trends Biotechnol. 2002; 20(6): 243–248.
2. Ciarrocca M, Rosati MV, Tomei F, Capozzella A, Andreozzi G, Tomei G, Bacaloni A, Casale T, Andre`JC, Fioravanti M, Cuartas MF, Caciari T. Is urinary 1-hydroxypyrene a valid biomarker for exposure to air pollution in outdoor workers? A meta-analysis. J Exp Sci Env Epidemiol. 2014; 24:17–26.
3. http://monographs.iarc.fr/ENG/Classification/latest_classif.php (accessed: 04.04.2017).
4. Chen S-C, Liao C-M. Health risk assessment on human exposed to environmental polycyclic aromatic hydrocarbons pollution sources. Sci Total Environ. 2006; 366:112–123.
5. Lee MS, Magari S, Christiani DC. Cardiac autonomic dysfunction from occupational exposure to polycyclic aromatic hydrocarbons. Occup Environ Med. 2010; 68: 474–478.
6. Apostoli P, Porru S. Biological monitoring and risk assessment. In:. Advances in Occupational Medicine vol. 1. Maugeri Foundation Books: Pavia, 2000. pp 227–233.
7. Ifegwu C, Osunjaye K, Fashogbon F, Oke K, Adeniyi A, Anyakora C. Urinary 1-hydroxypyrene as a biomarker to carcinogenic polycyclic aromatic hydrocarbon exposure. Biomarkers Cancer. 2012; 4:7–17.
8. Förster K, Preuss R, Roßbach B, Brüning T, Angerer J, Simon P. 3-hydroxybenzo[a]pyrene in the urine of workers with occupational exposure to polycyclic aromatic hydrocarbons in different industries. Occup Environ Med. 2008; 65:224–229.
9. Jongeneelen FJ. Benchmark guideline for urinary 1-hydroxypyrene as biomarker of occupational exposure to polycyclic aromatic hydrocarbons. Ann Occup Hyg. 2001; 45(1): 3–13.
10. Yamano, Y., Hara, K., Ichiba, M, Hanaoka T, Pan G, Nakadate T. Urinary 1-hydroxypyrene as a comprehensive carcinogenic biomarker of exposure to polycyclic aromatic hydrocarbons: a cross-sectional study of coke oven workers in China. Arch Occup Environ Health. 2014; 87: 705–713.
11. Käfferlein, H.U., Marczynski, B., Simon, P, Angerer J, Rihs H-P, Wilhelm M, Straif K, Pesch B, Brüning T. Internal exposure to carcinogenic polycyclic aromatic hydrocarbons and DNA damage: a null result in brief. Arch Toxicol. 2012; 86: 1317 – 1321.
12. Jongeneelen FJ. A guidance value of 1-hydroxypyrene in urine in view of acceptable occupational exposure to polycyclic aromatic hydrocarbons. Toxicol Let. 2014; 231 (2):239–248.
13. http://www.inrs.fr/publications/bdd/biotox/dosage.html?refINRS=Dosage_151 (accessed: 04.04.2017).
14. Simon P, Morele Y, Delsaut P, Nicot T. Automated column-switching high-performance liquid chromatography method for the determination of 1-hydroxypyrene in human urine. J Chromatogr B Biomed Sci Appl. 1999; 732: 91–101.
15. Taussky H. A micro-colorimetric determination of creatinine in urine by Jaffe´ reaction. J Biol Chem. 1954; 208: 853–861.
16. https://www.cdc.gov/nchs/nhis/tobacco/tobacco_glossary.htm (accessed: 19.04.2017).
17. Ahn YS, Park RM, Stayner L, Kang SK, Jang JK. Cancer morbidity in iron and steel workers in Korea. Am J Ind Med. 2006; 49(8):647–657.
18. Pless-Mulloli T, Phillimore P, Moffatt S, Bhopal R, Foy C, Dunn C, Tate J. Lung cancer, proximity to industry and poverty in northeast England. Environ Health Perspect, 1998, 106(4):189–196.
19. Rafiei M, Gadgil A, Patil H, Jamir T. Evaluation of health consequences of air pollution induced by Beam Rolling Mills Factory (Iran), PESD. 2015; 8(2):63–73.
20. Campo L, Vimercati L, Carrus A, Bisceglia L, Pesatori AC, Bertazzi PA, Assennato G, Fustinoni S. Environmental and biological monitoring of PAHs exposure in coke-oven workers at the Taranto plant compared to two groups from the general population of Apulia, Italy. Med Lav 2012; 103, 5: 347–360.
21. Hansen ÅM, Mathiesen L, Pedersen M, Knudsen LE. Urinary 1-hydroxypyrene (1-HP) in environmental and occupational studies—A review. Int J Hygiene Environ Health. 2008; 211: 471–503.
22. Huang W, Grainger J, Patterson DG, Turner WE, Caudill SP, Needham LL, Pirkle JR, Sampson EJ. Comparison of 1-hydroxypyrene exposure in the US population with that in occupational exposure studies. Int Arch Occup Environ Health. 2004; 77:491.
23. Talaska G, Thoroman J, Schuman B, Käfferlein HU. Biomarkers of polycyclic aromatic hydrocarbon exposure in European coke oven worker. Toxicol Let. 2014; 231: 213–216.
24. Chen B, Hu Y, Jin T, Zheng L, Wang Q, Shen Y, Zhou Y. Higher urinary 1-hydroxypyrene concentration is associated with cooking practice in a Chinese population. Toxicol Lett. 2007; 171(3): 119–125.
25. Mucha AP, Hryhorczuk D, Serdyuk A, Nakonechny J, Zvinchuk A, Erdal S, Caudill M, Scheff P, Lukyanova E, Shkiryak-Nyzhnyk Z, Chislovska N. Urinary 1-hydroxypyrene as a biomarker of PAH exposure in 3-year-old Ukrainian children. Environ Health Persp. 2006; 114: 603–609.
26. Rubino FM, Verduci C, Buratti M, Fustinoni S, Neri L, Brambilla G. Biomonitoring of exposure to PAH: the pyrene vs. 1-hydroxypyrene paradox. G Ital Med Lav Ergon. 2004; 26(4):98–99.
27. Bartolomé M, Ramos JJ, Cutanda F, Huetos O, Esteban M, Ruiz-Moraga M, Calvo E, Pérez-Gómez B, González O, BIOAMBIENT.ES, Castaño A. Urinary polycyclic aromatic hydrocarbon metabolites levels in a representative sample of the Spanish adult population: The BIOAMBIENT.ES project. Chemosphere. 2015; 135: 436–446.
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ISSN:1232-1966