The role of vitamin D in reproductive dysfunction in women – a systematic review

Ewa Pastuszek 1, 2,  
Paweł Kuć 3, 4,  
Grzegorz Jakiel 6, 7,  
Department of Obstetrics and Gynecological Nursing, Faculty of Health Sciences, Medical University of Gdansk, Poland
INVICTA Fertility and Reproductive Center, Gdańsk, Poland
Centre for Reproductive Medicine KRIOBANK, Białystok, Poland
Medical University of Bialystok, Poland
Department of Chemical and Process Engineering Chemical Faculty, Gdansk University of Technology, Poland
INVICTA Fertility and Reproductive Center, Warszawa, Poland
First Department of Obstetrics and Gynaecology, Medical Center of Postgraduate Education, Warsaw, Poland
Institute of Animal Reproduction and Food Research of the Polish Academy of Sciences, Department of Reproductive Immunology and Pathology, Olsztyn, Poland
Department of Gyneacological Endocrinology, Medical University of Warsaw, Warsaw, Poland
Ann Agric Environ Med 2016;23(4):671–676
Vitamin D is essential for the proper functioning of the human body. There is also evidence of its strong association with fertility problems in women. This review aims to evaluate the relationship between vitamin D and diseases affecting women’s fertility (polycystic ovarian syndrome (PCOS), uterine leiomyomas and endometriosis), and in vitro fertilization (IVF) outcome. A systematic review of the literature was conducted in Scopus and PubMed for relevant English language publications since 1989. Vitamin D influences the functioning of the reproductive system in women and has been associated with PCOS, uterine leiomyomas, endometriosis and in vitro fertilization (IVF) outcome. However, further studies on larger groups of patients are needed to establish what role vitamin D plays in the treatment of female infertility.
Patrycja Skowrońska   
Department of Obstetrics and Gynecological Nursing, Faculty of Health Sciences, Medical University of Gdansk, Poland
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