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RESEARCH PAPER
 
CC BY-NC-ND 3.0
 
 

Influence of biological factors on injuries occurrence in the Polish population

Marek Sawczuk 1,  
Jerzy Eider 1,  
Marian Sygit 1, 4,  
 
1
Faculty of Physical Education and Health Promotion, University of Szczecin, Poland
2
Academy School of Physical Education in Katowice, Poland
3
Department of Clinical and Molecular Biochemistry, Pomeranian Medical University of Szczecin, Poland
4
Institute of Rural Health in Lublin, Poland
5
Department of Sport Education, Academy of Physical Education and Sport, Gdansk, Poland
6
Department of Orthopaedics, Traumatology and Oncology, Pomeranian Medical University of Szczecin, Poland
Ann Agric Environ Med 2016;23(2):315–318
KEYWORDS:
ABSTRACT:
Introduction and objective:
Anterior cruciate ligament rupture is one of the most common knee injuries in sports. Although various intrinsic and extrinsic risk factors have been identified, the exact aetiology of the injury is not yet fully understood. Single nucleotide polymorphisms (SNPs) in the collagen type I (COL1A1) gene have been shown to be associated with several complex connective tissue disorders. The aim of this study was to examine the association of -1997G/T polymorphisms in the COL1A1 gene with ACL ruptures in Polish recreational skiers in a case-control study.

Material and Methods:
A total of 180 male and female recreational skiers with surgically diagnosed with primary ACL ruptures were recruited for the study, all of whom qualified for ligament reconstruction. The control group was comprised of 245 apparently healthy male and female skiers with a comparable level of exposure to ACL injury, none of whom had any self-reported history of ligament or tendon injury. DNA samples extracted from the oral epithelial cells were genotyped for -1997G/T polymorphisms using PCR method.

Results:
Genotype distribution in the cases (GG-82.2% GT-16.7%; TT-1.1%) showed significant difference (P=0.036) compared to controls (GG-71.4% GT-26.5%; TT-2.2%). The frequency of the GG genotype in the ACL rupture group was also statistically significant (p=0.011, Fisher’s exact test recessive mode: GG vs GT+TT). The frequency of the G allele was higher in these cases (90.6%), and also statistically significant (p=0.012) when compared with controls (84.7%).

Conclusions:
The results obtained indicate that the -1997G/T COL1A1 gene is one of the genetic markers to be taken into the consideration in the identification of the risk of ACL injury.

CORRESPONDING AUTHOR:
Marta Stępień-Słodkowska   
Faculty of Physical Education and Health Promotion, University of Szczecin, Poland
 
REFERENCES:
1. Tovar N, Bourke S, Jaffe M, Murthy NS, Kohn J, Gatt C, Dunn MGA. Comparison of degradable synthetic polymer fibers for anterior cruciate ligament reconstruction. J Biomed Mater Res A. 2010; 93(2): 738–747.
2. Dhillon MS, Bali K, Prabhakar S. Proprioception in anterior cruciate ligament deficient knees and its relevance in anterior cruciate ligament reconstruction Indian. J Orthop. 2011; 45(4): 294–300.
3. O’Connell K, Saunders CJ, Collins M. Collagen gene sequence variants in exercise-related traits. Cent Eur J Sport Sci Med. 2013; 1(1): 3–17.
4. Amor MB, Glorieux FH, Rauch F. Genotype-phenotype correlations in autosomal dominant osteogenesis imperfecta. J Osteoporos. 2011: 540178.
5. Frank CB. Ligament structure, physiology and function. J Musculoskel Neuron Interact. 2004; 4(2): 199–201.
6. Hurd WJ, Axe M, Snyder-Mackler L, Influence of age, gender, and injury mechanism on the development of dynamic knee stability after acute ACL rupture. J Orthop Sports Phys Ther. 2008; 38(2): 36–41.
7. Legnani C, Terzaghi C, Borgo E, Ventura A. Management of anterior cruciate ligament rupture in patients aged 40 years and older. J Orthop Traumatol. 2011; 12(4): 177–184.
8. September AV, Schwellnus MP, Collins M. Tendon and ligament injuries: the genetic component. Br J Sports Med. 2007; 41(4): 241–246.
9. Yu B, Garrett WE. Mechanisms of non-contact ACL injuries. Br J Sports Med. 2007; 41(1): 47–51.
10. Farshad M, Gerber C, Meyer DC, Schwab A, Blank PR, Szucs T. Reconstruction versus conservative treatment after rupture of the anterior cruciate ligament: cost effectiveness analysis. Health Serv Res. 2011; 11: 317.
11. Habelt S, Hasler CC, Steinbrück K, Majewski M. Sport injuries in adolescents. Orthop Rev (Pavia) 2011; 3(2): 18.
12. Kim S, Endres NK, Johnson RJ, Ettlinger CF, Shealy JE. Snowboarding injuries: trends over time and comparisons with alpine skiing injuries. Am J Sports Med. 2012; 40(4): 770–6.
13. Benjaminse A, Lemmink K, Diercks RL, Otten B. An investigation of motor learning during side-step cutting, design of a randomised controlled trial. Musculoskelet Disord. 2010; 11: 235.
14. Swärd P, Kostogiannis I, Roos H. Risk factors for a contralateral anterior cruciate ligament injury. Knee Surg Sports Traumatol Arthrosc. 2010; 18 (3): 277–91.
15. Zhang D, Shi Y, Gong B, He F, Lu F, Lin H, Wu Z, Cheng J, Chen B, Liao S, Ma S, Hu J, Yang Z. An association study of the COL1A1 gene and high myopia in a Han Chinese population. Epub. 2011; 17: 3379–83.
16. Meyer , Haist , Schaefer , Ivan , Ittner , Nawroth , Plöckinger , Stalla , Tuschy , Weber , Weise A, Pfützner , Habbe N. Kann PH. Association of COLIA1 Sp1 polymorphism with the effect of subcutaneously injected recombinant hGH in GH-deficient adults Pharmacogenomics. 2008; 9(8): 1017–1026.
17. Collins M, Raleigh S. Genetics Risk Factors for Musculoskeletal Soft Tissue Injuries. Med Sport Sci. 2009; 54: 136–49.
18. Posthumus M, September AV, Keegan M, O’Cuinneagain D, Van Der Merwe W, Schwellnus MP, Collins M. Genetic risk factors for anterior cruciate ligament ruptures: COL1A1 gene variant. Br J Sports Med. 2009; 43(5): 352–6.
19. Kruk J. Good scientific practice and ethical principles in scientific research and higher education. Cent Eur J Sport Sci Med. 2013; 1(1): 25–29.
20. September AV, Cook J, Handley CJ, Van Der Merwe L, Schwellnus MP, Collins M. Variants within the COL5A1 gene are associated with Achilles tendinopathy in two populations. Br J Sports Med. 43, 357–365, 2009.
21. Collins M, Posthumus M, Schwellnus MP, The COL1A1 gene and acute soft tissue. Ruptures. Br J Sports. 2009; 44: 1063–1064.
22. Hewett TE. Prevention of non-contact ACL injuries in Women: Use of the core of evidence to clip the wings of a “Black Swan”. Curr Sports Med Rep. 2009; 8: 219–21.
23. Flyn RK, Pedersen CL, Birmingham TB, Kirkley A, Jackowski D, Fowler PJ. The familial predisposition toward tearing the anterior cruciate ligament: a case control study. Am J Sports Med. 2005; 33: 23–8.
24. Sawczuk M, Maciejewska A, Cięszczyk P, Eider J. The Role of genetic research in sport. Science&Sports. 2011; 26: 251–8.
25. Mokone GG, Schwellnus MP, Noakes TD, Collins M. The COL5A1 gene and Achilles tendon pathology. Scand J Med Sci Sports. 2006; 16: 19–26.
26. Laguette MJ, Abrahams Y, Prince S, Collins M. Sequence variants within the 3’-UTR of the COL5A1 gene alters mRNA stability: Implications for musculoskeletal soft tissue injuries. Matrix Biology 2011; 30: 338–45.
27. Malila S, Yuktanandana P, Saowaprut S, Jiamjarasrangsi W, Honsawek S. Association between matrix metalloproteinase-3 polymorphism and anterior cruciate ligament ruptures. Genet Mol Res. 2011; 10: 4158–65.
28. Horn SD. Goodness-of-fit tests for discrete data: a review and an application to a health impairment scale. Biometrics. 1977; 33: 237–47.
29. Khoshnau S, Melhus H, Jacobson A, Rahme H, Bengtsson H, Ribom E, Grundberg E, Mallmin H, Michaëlsson K. Type I collagen alpha1 Sp1 polymorphism and the risk of cruciate ligament ruptures or shoulder dislocations. Am J Sports Med. 2008; 36: 2432–6.
30. Collins M, Posthumus M, Schwellnus M. The COL1A1 gene and acute soft tissue ruptures. Br J Sports Med. 2010; 44: 1063–4.
31. Posthumus M, September AV, O’cuinneagain D, Van Der Merwe W, Schwellnus MP, Collins M. The COL5A1 gene is associated with increased risk of anterior cruciate ligament ruptures in females. Am J Sports Med. 2009; 37: 2234–2240.
32. September AV, Posthumus M, Van Der Ml, Schwellnus M, Noakes TD, Collins M. The COL12A1 and COL14A1 genes and Achilles tendon injuries. Int J Sports Med. 2008; 29: 257–263.
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