RESEARCH PAPER
Event-related potentials (ERP) and SGIP1 gene polymorphisms in alcoholics: relation to family history of alcoholism and drug usage
 
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1
Department of Neurodegenerative Diseases, Institute of Rural Health, Lublin, Poland
2
Department of Physiopathology, Institute of Rural Health, Lublin, Poland
3
Department of Molecular Biology and Translational Research, Institute of Rural Health, Lublin, Poland
CORRESPONDING AUTHOR
Roman Chwedorowicz   

Department of Neurodegenerative Diseases, Institute of Rural Health, Lublin, Poland
 
Ann Agric Environ Med. 2016;23(4):618–624
KEYWORDS
ABSTRACT
Objective:
The electrophysiological characteristics may serve as valuable biomarkers for the genetic vulnerability underlying alcoholism. The purpose of this study was to evaluate the potential associations between single nucleotide polymorphisms (SNPs) located in the SGIP1 gene and the theta ERP quantitative traits.

Method:
The theta band (4–7 Hz) visual ERP occurring in the P300 response in the resting EEG were examined to explore the electrophysiological effects of alcohol on the brain in five regions: frontal, central, parietal, temporal and occipital in patients with alcohol addiction. In addition, we tested the potential associations between single nucleotide polymorphisms (SNPs) located in the SGIP1 gene and ERP quantitative traits.

Results:
We found that the amplitude of the auditory P300 response differed considerably among groups of alcoholics in the frontal, central and temporal areas of the brain and it was lower in the studied brain regions in alcoholics in comparison to non-alcoholics. However, among subjects in the young adult group (GR-1) there was no statistical difference in amplitude of P300 response with control subjects in all studied brain regions in comparison with non-alcoholics. Moreover, we revealed that SNP rs10889635 had a significant effect on P300 amplitude in the central and temporal regions. The reduced P300 amplitude was in AA carriers in comparison to both carriers of GG and GA alleles.

Conclusions:
The present study demonstrated a possible association of target P300 evoked theta and of alcohol dependence with SNPs from the gene SGIP1 in the region of rs10889635, but further studies are required.

 
REFERENCES (25)
1.
Kendler KS, Prescott CA, Myers J, Neale MC. The structure of genetic and environmental risk factors for common psychiatric and substance use disorders in men and women. Arch Gen Psychiatry 2003; 60: 929–937.
 
2.
Sygit K, Kołłątaj W, Wojtyła A, Sygit M, Bojar I, Owoc A. Engagement in risky behaviours by 15-19-year-olds from Polish urban and rural areas. Ann Agric Environ Med. 2011; 18: 404–409.
 
3.
Cservenka A. Neurobiological phenotypes associated with a family history of alcoholism. Drug Alcohol Depend. 2016; 158: 8–21.
 
4.
Porjesz B, Rangaswamy M, Kamarajan C, Jones KA, Padmanabhapillai A, Begleiter H. The utility of neurophysiological markers in the study of alcoholism. Clin. Neurophysiol. 2005; 116: 993–1018.
 
5.
Porjesz B, Rangaswamy M. Neurophysiological endophenotypes, CNS disinhibi tion, and risk for alcohol dependence and related disorders. Scientific World Journal 2007; 7: 131–141.
 
6.
Hodgkinson CA, Enoch MA, Srivastava V, Cummins-Oman JS, Ferrier C, Iarikova P, et al. Genome-wide association identifies candidate genes that influence the human electroencephalogram. Proc Natl Acad Sci. 2010; 107: 8695–8700.
 
7.
Cservenka A, Nagel BJ. Risky decision-making: an fMRI study of youth at high risk for alcoholism. Alcohol Clin Exp Res. 2012; 36: 604–615.
 
8.
Uezu A, Horiuchi A, Kanda K, Kikuchi N, Umeda K, Tsujita K, et al. SGIP1alpha is an endocytic protein that directly interacts with phospholipids and Eps1 J Biol Chem. 2007; 282: 26481–26489.
 
9.
Derringer J, Krueger RF, Manz N, Porjesz B, Almasy L, Bookman E, et al. Nonreplication of an association of SGIP1 SNPs with alcohol dependence and resting theta EEG power. Psychiatr Genet. 2011; 21: 265–266.
 
10.
Chen AC, Manz N, Tang Y, Rangaswamy M, Almasy L, Kuperman S, et al. Single-nucleotide polymorphisms in corticotropin releasing hormone receptor 1 gene (CRHR1) are associated with quantitative trait of event-related potential and alcohol dependence. Alcohol Clin Exp Res. 2010; 34: 988–996.
 
11.
Jones KA, Porjesz B, Almasy L, Bierut L, Dick D, Goate A, et al. A cholinergic receptor gene (CHRM2) affects event-related oscillations. Behav Genet. 2006; 36: 627–639.
 
12.
Hill SY, Jones BL, Holmes B, Steinhauer SR, Zezza N, Stiffler S . Cholinergic receptor gene (CHRM2) variation and familial loading for alcohol dependence predict childhood developmental trajecto ries of P30 Psychiatry Res. 2013; 209: 504–511.
 
13.
Wang JC, Hinrichs AL, Stock H, Budde J, Allen R, Bertelsen S, et al. Evidence of common and specific genetic effects: Association of the muscarinic acetylcholine receptor M2 (CHRM2) gene with alcohol dependence and major depressive syndrome. Hum Mol Gen. 2004; 13: 1903–1911.
 
14.
Dick DM, Agrawal A, Wang JC, Hinrichs A, Bertelsen S, Bucholz KK, et al. Alcohol dependence with comorbid drug dependence: Genetic and phenotypic associations suggest a more severe form of the disorder with stronger genetic contribution to risk. Addiction 2007; 102: 1131–1139.
 
15.
Kang SJ, Rangaswamy M, Manz N, Wang JC, Wetherill L, Hinrichs T, et al. Family-based genome-wide association study of frontal theta oscillations identifies potassium channel gene KCNJ Genes Brain Behav. 2012; 11: 712–719.
 
16.
Saenz del Burgo L, Cortes R, Mengod G, Zarate J, Echevarria E, Salles J. Distribution and neurochemical characterization of neurons expressing GIRK channels in the rat brain. J Com Neurol. 2008; 510: 581–606.
 
17.
Polich J, Ladish C, Bloom FE. P300 assessment of early Alzheimer’s disease. Electroencephalogr Clin Neurophysiol. 1990; 77: 179–89.
 
18.
Cohen HL, Wang W, Porjesz B, Begleiter H. Auditory P300 in young alcoholics: Regional response characteristics. Alcohol Clin Exp Res. 1995; 19, 469–475.
 
19.
Benegal V, Jain S, Subbukrishna DK, Channabasavanna SM. P300 ampli tudes vary inversely with continuum of risk in first degree male relatives of alcoholics. Psych Gen. 1995; 5: 149–156.
 
20.
Hill SY, Steinhauer S, Lowers L, Locke J. Eight-year longitudinal follow-up of P300 and clinical outcome in children from high-risk for alcoholism families. Biol Psychiatry 1995; 37: 823–827.
 
21.
Bauer LO, Hesselbrock VM. P300 decrements in teenagers with conduct problems: implications for substance abuse risk and brain development. Biol Psychiatry 1999; 46: 264.272.
 
22.
Rodriguez-Holguin SC, Corral M, Cadaveira F. Visual and auditory event-related potentials in young children of alcoholics from high- and low-density families. Alcohol Clin Exp Res. 1998; 22: 87–96.
 
23.
Ehlers CL, Phillips E, Sweeny A, Slawecki CJ. Event-related potential responses to alcohol-related stimuli in African-American young adults: relation to family history of alcoholism and drug usage. Alcohol Alcohol. 2003; 38: 332–338.
 
24.
Polich J, Herbst KL. P300 as a clinical assay: rationale, evaluation, and findings. Int J Psychophysiol. 2000; 38: 3–19.
 
25.
Polich J, Pollock VE, Bloom FE. Meta-analysis of P300 amplitude from males at risk for alcoholism. Psychol Bull. 1994; 115: 55–73.
 
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