RESEARCH PAPER
Differences in the expression of selected genes associated with cell stress response in a PTSD patient and in healthy individuals – a case study
 
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1
Institute of Psychology, Kazimierz Wielki University, Bydgoszcz, Poland
2
Faculty of Medicine and Health Sciences, Jan Kochanowski University in Kielce, Kielce, Poland
3
The Old Polish University, Kielce, Poland
4
Department of Life Sciences, Gdańsk University of Physical Education and Sport, Gdańsk, Poland
5
Chair of Neuropsychology, The Andrzej Frycz-Modrzewski Cracow University, Kraków, Poland
6
The Department of Physiotherapy, Academy of Physical Education, Katowice, Poland
 
Ann Agric Environ Med. 2017;24(2):332–337
KEYWORDS:
ABSTRACT:
Objective:
The aim of the study was determination of the level in expression genes associated with cell stress response in a patient with PTSD.

Case study:
A 57-year-old PTSD patient, A.P., was the subject of the study. Blood samples were taken from the ulnar vein to assess the relative expression of the tested genes in leukocytes via a quantitative reverse transcription polymerase chain reaction (qRT-PCR).

Results:
A considerably decreased level in the expression HSF-1, NF-kB, Hif-1 and IL6 m-RNA was observed in the patient when compared to the control group. A low expression in HSPA1A, HSPB1, IL10 and CRP m-RNA compared with the control group was also noted.

Conclusions:
It is possible that the lower level of transcriptional factors: HSF-1, NF-kB and Hif-1 as well as IL6 m-RNA may be associated with the effect of the PTSD patient’s treatment.

 
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