0.829
IF
20
MNiSW
166.26
ICV
RESEARCH PAPER
 
CC BY-NC-ND 3.0
 
 

Cerebral toxoplasmosis after haematopoietic stem cell transplantation

Joanna Dubelt 2,  
 
1
Department of Paediatric Haematology, Oncology and Transplantology, Medical University, Lublin, Poland
2
Department of Paediatric Neurology, Medical University, Lublin, Poland
Ann Agric Environ Med 2017;24(2):237–239
KEYWORDS:
ABSTRACT:
Toxoplasmosis is an opportunistic infection caused by the parasite Toxoplasma gondii. The infection is severe and difficult to diagnose in patients receiving allogeneic haematopoietic stem cell transplantation (HSCT). It frequently involves the central nervous system. The case is presented of cerebral toxoplasmosis in a 17-year-old youth with Fanconi anaemia treated with haematopoietic stem cell transplantation (HSCT)
CORRESPONDING AUTHOR:
Agnieszka Zaucha-Prażmo   
Department of Paediatric Haematology, Oncology and Transplantology, Medical University, Lublin, Poland
 
REFERENCES:
1. Meers S, Lagrou K, Theunissen K, Dierickx D, Delforge M, Devos T et al. Myeloablative conditioning predisposes patients for Toxoplasma gondi reactivation after allogeneic stem cell transplantation, Clin Infect Dis 2010; 50:1127–1134.
2. Martino R, Bretagne s, Einsele H, Maertens J, Ulmann AJ, Parody R et al. Early detection of Toxoplasma infection by molecular monitoring of Toxoplasma gondii in peripheral blood samples after allogeneic stem cell transplatation. Clin Infect Dis 2005; 40:67–78.
3. Mulanovich VE, Ahmed SI, Ozturk T, Khokhar FA, Kontoyiannis DP, de Lima M. Toxoplasmosis in allo-SCT patients: risk factors and outcomes at a transplantation center with a low incidence. Bone Marrow Transplant. 2011; 46(2): 273–277.
4. Voegele L, Cheerva AC, Bertolone S. Cerebral toxoplasmosis after tandem high-dose chemotheraphy and autologous hematopoietic cell transplant for neuroblastoma. J Pediatr Hematol Oncol. 2013; 35(2):e50–52.
5. Samardakiewicz M. Optymalizacja metod wspomagania biopsycho-społecznego dzieci leczonych z powodu choroby nowotworo wej: rozprawa habilitacyjna. 2008, Medical University, LublinLublin 2008, Uniwersytet Medyczny w Lublinie,.
6. Kazak, A., Barakat, L., Ditaranto, S., Biros, D., Hwang, W.T., Beele, D, Kersun L, Alderfer MA, Mougianis I, Hocking MC, Reilly A.. Screening for psychosocial risk at cancer diagnosis. Psychosocial Assessment Tool (PAT). J Ped Hemat, 2011; 33(4) 289–294.
7. Liu Y, Ballman K, Khan S, Derr-Yellin E, Shou W, Haneline LS. Impared function of Fanconi anemia type C-deficient macrophages. J Leukoc Biol 2012; 91(2):333–3340.
8. Myers KC, Bleesing JJ, Davies SM, Zhang X, Martin LJ, Mueller R, et al. Impaired immune function in children with Fanconi anaemai. Br J Haematol. 2011; 154(2):234–240.
9. Fricker-Hidalgo H, Bulabois CE, Brennier-Pinchart MP, Hamidfar R, Garban F, Brion JC et al. Diagnosis of toxoplasmosis after allogeneic stem cel transplantation: result of DNA detection and serological techiques. Clin Infect Dis 2009; 48:e9–15.
10. Lim Z, Baker B, Zuckermann M, Wade JJ, Ceesav M, Ho AY et al. Toxoplasmosis following alemtuzumab-based allogeneic haemato-poietic stem cell transplantation. J Infect 2007; 54:E83–86.
11. Walker M, Zunt J. Parasytic central nervous system infection in immunocompromised host. Clin Infect Dis 2005; 40:1005–1015.
12. Hakko E, Ozkan HA, Karaman K, Gulbas Z. Analysis of cerebral toxoplasmosis in a series of 170 allogeneic hematopoietic stem cell transplant patients. Transpl Infect Dis. 2013; 15(6):575–580.
13. Sumi M, Aosai E, Norose K, Takeda W, Kirihara T, Sato K et al. Acute exacerbation of Toxoplasma gondii infection after hematopoietic stem cell transplantation: five case reports among 279 recipients. Int J Hematol. 2013; 98(2):214–222.
14. Stajner T, Vasiljevic Z, Vujic D, Markovic M, Ristic G, Micic D et al. Atypical strain of Toxoplasma gondi causing fatal reactivation after hematopoietic stem cell transplantation in a patient with an underlying immunological deficiency. J Clin Microbiol. 2013; 51(8): 2686–2690.
15. Caselli D, Andreoli E, Paolicchi O, Savelli S, Guidi S, Pecile P et al. Acute encephalopathy in the immune-compromised child: never forget toxoplasmosis. J Pediatr Hematol Oncol. 2012; 34(5): 383–386.
16. Rossi CL, Nascimento FS, de Barros-Mazon S, Dias DF, Vigorito AC, de Souza CA. Serological monitoring of a Toxoplasma infection after hematopoietic stem cell transplantation. Rev Inst Med Trop. 2010; 50(4):225–227.
17. Cavattoni I, Ayuk F, Zander AR, Zabelina T, Bacher A, Cayroglu E et al. Diagnosis of Toxoplasma gondii infection after allogeneic stem cell transplan can be difficult and requires intensive scrutiny. Leuk Lymphoma. 2010; 51(8):1530–1535.
18. Kearney JA, Hay JL, Halpern L, Boulad F. Peritransplant psychiatric evaluation of patients with Fanconi anemia. J Ped Hematol Oncol. 2012; 34(3):163–168.
19. Cincotta NF, Psychosocial Issues [W:]. Hays L (ed) Fanconi Anemia:Guidelines for Diagnosis and Management. Fanconi Anemia Ressearch Foundation, Fourth Edition 2014, p.333–352.
eISSN:1898-2263
ISSN:1232-1966