0.829
IF
20
MNiSW
166.26
ICV
RESEARCH PAPER
 
CC BY-NC-ND 3.0
 
 

A new method for setting guidelines to protect human health from agricultural exposure by using chlorpyrifos as an example

Dung Tri Phung 1  ,  
Des Connell 2,  
 
1
Centre for Environment and Population Health, Griffith School of the Environment, Griffith University, Nathan, Australia
2
Griffith School of Environment, Griffith University, Nathan, Australia
Ann Agric Environ Med 2015;22(2):275–280
KEYWORDS:
ABSTRACT:
Introduction and objectives:
Guidelines set by various agencies for the control and management of chlorpyrifos cover a wide range of values reflecting difficulties in the procedures for their development. To overcome these difficulties a new method to set guidelines would be developed. Published data derived from epidemiological investigations on human populations would be used to develop a dose-response relationship for chlorpyrifos allowing the calculation of threshold values which can be used as guidelines.

Material and Methods:
Data from the scientific literature on human populations were collected to evaluate the adverse response doses for a range of health effects. The Cumulative Frequency Distribution (CFD) for the minimum levels of adverse effects measured in terms of the Lifetime Average Daily Dose (LADD[sub]D[/sub]) and the Absorbed Daily Dose for neurological (ADD[sub]DN[/sub]) and non-neurological effects were used.

Results:
Linear regression equations were fitted to the CFD plots giving R 2 values of 0.93 and 0.86 indicating a normal distribution of the data. Using these CFD plots, the chronic and acute threshold values were calculated at the 5% cumulative frequency level for chlorpyrifos exposure giving values at 0.5 µg/kg/d and 3 µg/kg/d respectively.

Conclusions:
Guidelines set using this technique at the values at 0.5 µg/kg/d and 3 µg/kg/d for chronic and acute exposure respectively provide an alternative to the currently used biological endpoint and safety factor method.

eISSN:1898-2263
ISSN:1232-1966