Thiram - Toxic inhalational lung injury
More details
Hide details
Chair and Department of Pneumonology, Oncology and Allergology, Medical University, Lublin, Poland
1st Department of Medical Radiology, Medical University, Lublin, Poland
Corresponding author
Anna Grzywa-Celińska   

Chair and Department of Pneumonology, Oncology and Allergology, Medical University , Lublin., ul. Jaczewskiego 8, 20-954, Lublin, Poland
Ann Agric Environ Med. 2019;26(4):672-673
Thiram, a fungicides, is widely used on seeds and as foliar agent on turf, vegetables and fruit. It is also used in the rubber industry as a vulcanization accelerator. When absorbed through the respiratory system, it is rapidly metabolised to dimethylthiocarbamate and carbon disulphide, causing noxious effects. A brief review is presented of the literature, centering on the interesting case of a 45-year-old woman admitted to the hospital suffering from acute respiratory failure.

Computer tomography in angiographic option (angio-CT) showed an extensive, irregular area of ground glass in both upper lobes and apical segments of the lower lobes of the lungs. A significant enlargement of both atria was also described. There was no improvement after cardiac treatment and patient was transferred to the pulmonary department where she was succesfully treated with systemic glucocortycosteroids. The patient remains under the supervision of the pulmonary out-patient department.

The authors thank dr Maciej Siczek of the Radiology Department, Hospital of the Ministry of Internal Affairs and Administration in Lublin, Poland, for assistance and comments that greatly improved the manuscript
Struciński P. Tiuram – pyły [Thiram – dusts]. Podstawy i Metody Oceny Środowiska Pracy. 2006; 3: 145–180. [polish].
Arrandale VH, Liss GM, Tarlo SM, Pratt MD, Sasseville D, Kudla I et al. Occupational Contact Allergens: Are They Also Associated With Occupational Asthma? Am J Ind Med. 2012; 55: 353–360.
Li Q, Kobayashi M, Kawada T. Carbamate Pesticide-Induced Apoptosis in Human T Lymphocytes. Int J Environ Res Public Health. 2015; 12: 3633-3645.
Cereser C, Boget S, Parvaz P, Revol A. Thiram-induced cytotoxicity is accompanied by a rapid and drastic oxidation of reduced glutathione with consecutive lipid peroxidation and cell death. Toxicology. 2001; 163: 153–162.
Journals System - logo
Scroll to top