Introduction and objective:
T2DM is a chronic disease with high prevalence. It can lead to a series of complications, causing severe damage to the body. The aim of the study is to examine the expression of miR-155 in patients with prediabetes and T2DM, and assessment of its diagnostic value.

Material and methods:
The biochemical indices of 96 prediabetic patients, 96 patients with T2DM, and 60 healthy subjects were measured using related instruments. The serum expression level of miR-155 in these three groups was detected through RT-qPCR. The early diagnostic value of miR-155 for T2DM was evaluated using a Receiver Operating Characteristic (ROC) curve. The predictive value of miR-155 for chronic complications in T2DM patients was assessed using a Kaplan-Meier curve. A logistic regression analysis was used to further assess the impact of miR-155 and other factors on T2DM complications.

Results:
The expression level of miR-155 was found to be down-regulated in the serum of patients with pre-diabetes and T2DM. MiR-155 demonstrated a significant ability to differentiate between prediabetic, T2DM, and healthy individuals. T2DM patients with low miR-155 expression were found to be more susceptible to complications. Therefore, miR-155 can be considered a risk factor for T2DM complications.

Conclusions:
The study highlighted the potential use of miR-155 in the early diagnosis and prognosis of T2DM. Additionally, miR-155 is somewhat associated with the onset and progression of T2DM complications