Respiratory health effects of fifteen years of improved collective protection in a wheat-processing worker population
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Service of Occupational Medicine, Institute for Work and Health, University of Lausanne and Geneva, Epalinges-Lausanne, Switzerland.
INRS, Scientific Management, Nancy, France
Service of Parasitology and Mycology, CHU de Besançon, Besançon, France
Service of Occupational Hygiene, Institute for Work and Health, University of Lausanne and Geneva, Route de la Corniche 2, CH-1066 Epalinges-Lausanne, Switzerland.
Ann Agric Environ Med. 2015;22(4):647-654
Occupational exposure to grain dust causes respiratory symptoms and pathologies. To decrease these effects, major changes have occurred in the grain processing industry in the last twenty years. However, there are no data on the effects of these changes on workers’ respiratory health.

The aim of this study was to evaluate the respiratory health of grain workers and farmers involved in different steps of the processing industry of wheat, the most frequently used cereal in Europe, fifteen years after major improvements in collective protective equipment due to mechanisation.

Material and Methods:
Information on estimated personal exposure to wheat dust was collected from 87 workers exposed to wheat dust and from 62 controls. Lung function (FEV1, FVC, and PEF), exhaled nitrogen monoxide (FENO) and respiratory symptoms were assessed after the period of highest exposure to wheat during the year. Linear regression models were used to explore the associations between exposure indices and respiratory effects.

Acute symptoms – cough, sneezing, runny nose, scratchy throat – were significantly more frequent in exposed workers than in controls. Increased mean exposure level, increased cumulative exposure and chronic exposure to more than 6 mg.m-3 of inhaled wheat dust were significantly associated with decreased spirometric parameters, including FEV1 and PEF (40 ml and 123 ml.s -1), FEV1 and FVC (0.4 ml and 0.5 ml per 100, FEV1 and FVC (20 ml and 20 ml per 100 h at >6 mg.m-3). However, no increase in FENO was associated with increased exposure indices.

The lung functions of wheat-related workers are still affected by their cumulative exposure to wheat dust, despite improvements in the use of collective protective equipment.

[No authors listed] Respiratory health hazards in agriculture. Am J Respir Crit Care Med. 1998; 158(5 Pt 2): S1-S76.
Rask-Andersen A. Asthma increase among farmers: a 12-year follow-up. Ups J Med Sci. 2011; 116(1): 60–71.
Kline JN, Jagielo PJ, Watt JL, Schwartz DA. Bronchial hyperreactivity is associated with enhanced grain dust-induced airflow obstruction. J Appl Physiol. 2000; 89(3): 1172–1178.
Pahwa P, Senthilselvan A, McDuffie HH, Dosman JA. Longitudinal decline in lung function measurements among Saskatchewan grain workers. Can Respir J. 2003; 10(3): 135–141.
Chaudemanche H, Monnet E, Westeel V, Pernet D, Dubiez A, Perrin C, Laplante JJ, Depierre A, Dalphin JC. Respiratory status in dairy farmers in France; cross sectional and longitudinal analyses. Occup Environ Med. 2003; 60(11): 858–863.
Jouneau S, Boche A, Brinchault G, Fekete K, Guillot S, Bayat S, Desrues B. On-site screening of farming-induced chronic obstructive pulmonary disease with the use of an electronic mini-spirometer: results of a pilot study in Brittany, France. Int Arch Occup Environ Health. 2012; 85(6): 623–630.
Spankie S, Cherrie JW. Exposure to grain dust in Great Britain. Ann Occup Hyg. 2012; 56(1): 25–36.
Halstensen AS, Nordby KC, Wouters IM, Eduard W. Determinants of microbial exposure in grain farming. Ann Occup Hyg. 2007; 51(7): 581–592.
Eduard W, Pearce N, Douwes J. Chronic bronchitis, COPD, and lung function in farmers: the role of biological agents. Chest. 2009; 136(3): 716–725.
Mounchetrou IN, Monnet E, Laplante JJ, Dalphin JC, Thaon I. Predictors of early cessation of dairy farming in the French Doubs province: 12-year follow-up. Am J Ind Med. 2012; 55(2): 136–142.
Thaon I, Thiebaut A, Jochault L, Lefebvre A, Laplante JJ, Dalphin JC. 2011. Influence of hay and animal feed exposure on respiratory status: a longitudinal study. Eur Respir J. 2011; 37(4): 767–774.
Venier AG, Chaudemanche H, Monnet E, Thaon I, Fury R, Laplante JJ, Dalphin JC. Influence of occupational factors on lung function in French dairy farmers. A 5-year longitudinal study. Am J Ind Med. 2006; 49(4): 231–237.
Senthilselvan A, Chenard L, Grover V, Kirychuk SP, Hagel L, Ulmer K, Hurst TS, Dosman JA. Excess longitudinal decline in lung function in grain farmers. J Agromedicine. 2010; 15(2): 157–165.
Halstensen AS, Heldal KK, Wouters IM, Skogstad M, Ellingsen DG, Eduard W. Exposure to grain dust and microbial components in the Norwegian grain and compound feed industry. Ann Occup Hyg. 2013; 57(9): 1105–1114.
Minette A. Questionnaire of the European Community for Coal and Steel (ECSC) on respiratory symptoms. 1987--updating of the 1962 and 1967 questionnaires for studying chronic bronchitis and emphysema. Eur Respir J. 1989; 2(2): 165–177.
Miller MR, Hankinson J, Brusasco V, Burgos F, Casaburi R, Coates A, Crapo R, Enright P, van der Grinten CP, Gustafsson P, Jensen R, Johnson DC, MacIntyre N, McKay R, Navajas D, Pedersen OF, Pellegrino R, Viegi G, Wanger J, Force AET. Standardisation of spirometry. Eur Respir J. 2005; 26(2): 319–338.
Pellegrino R, Viegi G, Brusasco V, Crapo RO, Burgos F, Casaburi R, Coates A, van der Grinten CP, Gustafsson P, Hankinson J, Jensen R, Johnson DC, MacIntyre N, McKay R, Miller MR, Navajas D, Pedersen OF, Wanger J. Interpretative strategies for lung function tests. Eur Respir J. 2005; 26(5): 948–968.
Dweik RA, Boggs PB, Erzurum SC, Irvin CG, Leigh MW, Lundberg JO, Olin AC, Plummer AL, Taylor DR. An official ATS clinical practice guideline: interpretation of exhaled nitric oxide levels (FENO) for clinical applications. Am J Respir Crit Care Med. 2011; 184(5): 602–615.
Viet SM, Buchan R, Stallones L. Acute respiratory effects and endotoxin exposure during wheat harvest in Northeastern Colorado. Appl Occup Environ Hyg. 2001; 16(6): 685–697.
Gainet M, Thaon I, Westeel V, Chaudemanche H, Venier AG, Dubiez A, Laplante JJ, Dalphin JC. Development of OASYS-2: a system for.
the analysis of serial measurement of peak expiratory flow in workers with suspected occupational asthma. Thorax. 1996; 51(5): 484–489.
Dimich-Ward H, Beking KJ, Dybuncio A, Bartlett KH, Karlen BJ, Chow Y, Chan-Yeung M. Respiratory health of two cohorts of terminal grain elevator workers studied 30 years apart. Am J Ind Med. 2011; 54(4): 263–268.
Kerstjens HA, Rijcken B, Schouten JP, Postma DS. Decline of FEV1 by age and smoking status: facts, figures, and fallacies. Thorax. 1997; 52(9): 820–827.
Wuthrich B, Schmid-Grendelmeier P, Schindler C, Imboden M, Bircher A, Zemp E, Probst-Hensch N. Prevalence of atopy and respiratory allergic diseases in the elderly SAPALDIA population. Int Arch Allergy Immunol. 2013; 162(2): 143–148.
von Mutius E, Braun-Fahrlander C, Schierl R, Riedler J, Ehlermann S, Maisch S, Waser M, Nowak D. Exposure to endotoxin or other bacterial components might protect against the development of atopy. Clin Exp Allergy. 2000; 30: 1230–1234.
Tossa P, Paris C, Zmirou-Navier D, Demange V, Acouetey DS, Michaely JP, Bohadana A. Increase in exhaled nitric oxide is associated with bronchial hyperresponsiveness among apprentices. Am J Respir Crit Care Med. 2010; 182: 738–744.
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