CASE REPORT
Figure from article: Atypical eczema-like skin...
 
KEYWORDS
TOPICS
ABSTRACT
Introduction:
Toxocariasis is the most widespread zoonotic parasitic infection, shared between humans, dogs, and wild canids. Clinical manifestations vary widely, often leading to delayed diagnosis, with allergic skin reactions and joint swelling being less common.

Case Report:
A 53-year-old man presented wityh unusual allergic skin symptoms, including a rash, blisters, and joint swelling. The symptoms occurred intermittently over several years.

Results:
Extensive testing yielded negative results, with the exception of anti-Toxocara antibodies, suggesting that Toxocara infection may have contributed to the symptoms or triggered an inflammatory response in the host. Albendazole therapy was initiated, resulting in an improvement in the skin symptoms.

Conclusions:
This cosmopolitan parasitic disease should always be considered in the diagnosis of allergic skin changes and joint swelling. Serological testing plays a crucial role in the diagnostics.
REFERENCES (28)
1.
Strube C, Raulf M-K, Springer A, et al. Chapter Nineteen -Seroprevalences of human toxocarosis in Europe: A review and meta-analysis. Adv Parasitol. 2020;109:375–418. https://doi.org/10.1016/bs.apa.... Epub 2020 Feb10.
 
2.
Chen J, Liu Q, Liu GH, et al. Toxocariasis: a silent threat with a progressive public health impact. Infect Dis Poverty. 2018;7:59. https://doi.org/10.1186/S40249....
 
3.
Raissi V, Raiesi O, Etemadi S, et al. Environmental soil contamination by Toxocara species eggs in public places of Ilam, Iran. Ann Agric Environ Med. 2020;27:15–8. https://doi.org/10.26444/AAEM/....
 
4.
Macpherson CNL. The epidemiology and public health importance of toxocariasis: a zoonosis of global importance. Int J Parasitol. 2013;43:999–1008. https://doi.org/10.1016/J.IJPA....
 
5.
Rostami A, Ma G, Wang T, et al. Human toxocariasis – A look at a neglected disease through an epidemiological “prism.” Infect Genet Evol. 2019;74. https://doi.org/10.1016/J.MEEG....
 
6.
Ma G, Holland CV, Wang T, et al. Human toxocariasis. Lancet Infect Dis. 2018;18:e14–24. https://doi.org/10.1016/S1473-....
 
7.
Despommier D. Toxocariasis: clinical aspects, epidemiology, medical ecology, and molecular aspects. Clin Microbiol Rev. 2003;16:265–72. https://doi.org/10.1128/CMR.16....
 
8.
Pawlowski Z. Toxocariasis in humans: clinical expression and treatment dilemma. J Helminthol. 2001;75:299–305. https://doi.org/10.1017/S00221....
 
9.
Abou-El-Naga I, Mogahed NMFH, Potential roles of Toxocara canis larval excretory – secretory molecules In immunomodulation and immune evasion. Acta Trop. 2023;238:106784. https://doi.org/10.1016/j.acta....
 
10.
Antonopoulos A, Giannelli A, Morgan ER, Charlier J. Quantifying the neglected: Initial estimation of the global burden and economic impact of human toxocariasis. Curr Res Parasitol Vector-Borne Dis. 2024;5. https://doi.org/10.1016/J.CRPV....
 
11.
Rostami A, Riahi SM, Holland CV, et al. Seroprevalence estimates for toxocariasis in people worldwide: A systematic review and meta-analysis. PLoS Negl Trop Dis. 2019;13. https://doi.org/10.1371/JOURNA....
 
12.
Noordin R, Yunus MH, Tan Farrizam SN, Arifin N. Serodiagnostic methods for diagnosing larval toxocariasis. Adv Parasitol. 2020;109:131–52. https://doi.org/10.1016/BS.APA....
 
13.
Hotez PJ. Toxocariasis: A neglected infection for the Anthropocene epoch. Adv Parasitol. 2020;109:879–83. https://doi.org/10.1016/BS.APA....
 
14.
Blum AJ, Hotez PJ. Global “worming”: Climate change and its projected general impact on human helminth infections. PLoS Negl Trop Dis. 2018;12:e0006370. https://doi.org/10.1371/JOURNA....
 
15.
Hotez PJ. Global urbanization and the neglected tropical diseases. PLoS Negl Trop Dis. 2017;11:e0005308. https://doi.org/10.1371/JOURNA....
 
16.
Mizgajska-Wiktor H, Jarosz W, Fogt-Wyrwas R, Drzewiecka A. Distribution and dynamics of soil contamination with Toxocara canis and Toxocara cati eggs in Poland and prevention measures proposed after 20 years of study. Vet Parasitol. 2017;234:1–9. https://doi.org/10.1016/J.VETP....
 
17.
Mizgajska-Wiktor H, Uga S. Exposure and environmental contamination. Toxocara: The Enigmatic Parasite. 2006:211–27. https://doi.org/10.1079/978184....
 
18.
Cunningham ET, Zierhut M. Ocular Toxocariasis. Ocul Immunol Inflamm. 2021;29:1243–5. https://doi.org/10.1080/092739....
 
19.
Nicoletti A. Neurotoxocariasis. Adv Parasitol. 2020;109:219–31. https://doi.org/10.1016/BS.APA....
 
20.
Gunawan H, Zulfan Z. Toxocariasis and Strongyloidiasis as Triggering Factors for Wells’ Syndrome. Clin Cosmet Investig Dermatol. 2024;17:1687–93. https://doi.org/10.2147/CCID.S....
 
21.
Zibaei M, Shayestek Z, Moradi N, Bahadoy S. Human Toxocara infection: Allergy and Immune Responces. Antiinflam. Antiallergy Agents Med Chem. 2019;18(2):82–90. https://doi.org/10.2174/187152....
 
22.
Lee TH, Ji YS, Lee SH. ELISA -Confirmed Bilateral Ocular Toxocariasis with Different Features. Optom Vis Sci. 2015;92(8):e176–9.
 
23.
Cueffi PP, zavallos Lescano SA, Rodriques E, et al. Human Toxocariasis: 2010 to 2020 Contributions from Brazilian Reserchers. Res Rep Trop Med. 2021;12:82–91. https://doi.org/10.2147/RRTM.S.... PMID:34040480: PMCID:PMC 8141392.
 
24.
Jõgi NO, Svanes C, Siiak SP, et al. Zoonotic helminth exposure and risk of allergic diseases: A study of two generations in Norway. Clin Exp Allergy. 2018;48:66–77. https://doi.org/10.1111/CEA.13....
 
25.
Huynk TM, Tan KQL, Dink TH, et al. Atypical Toxocara canis – Induced Hepatic Visceral Larva Migrans: Diagnostic Chalenges and Literature Review. Korean J Gastronterol. 2024;83(6):247–252. https://doi.org/10.4166/kjg.20....
 
26.
Chai JY, Jung BK, Hong SJ. Albendazole and mebendazole as Anti-Parasitic and Anti-Cancer Agents: an Update. Korean J Parasitol. 2021 Jun;59(3):189–225. https://doi.org/10.03347/kjp.2.... PMID:34218593. PMCID:PMC8255490.
 
27.
Henke K, Ntovas S, Xourgia E, et al. Who Let the Dogs out? – Unmasking the Neglected: A Semi-Systematic Review on the Enduring Impact of Toxocariasis: a Prevalent Zoonotic Infection. Int J Environ Res Public Health. 2023;20(21):6972. https://doi.org/10.3390/iierph.... PMID:37947530 PMCID:PMC10649795.
 
28.
Karagöz E, Selek MB, Aydın E, et al. Recurrent toxocariasis due to chronic urticaria and successful treatment with prolonged albendazole therapy. Turkiye Parazitol Derg. 2015;39:83–5. https://doi.org/10.5152/TPD.20....
 
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