RESEARCH PAPER
Serum selenium levels are associated with age-related cataract
 
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1
2nd Department of Ophthalmology, Pomeranian Medical University, Szczecin, Poland
2
Department of Genetics and Pathomorphology, Pomeranian Medical University, Szczecin, Poland
3
1st Department of Ophthalmology, Pomeranian Medical University, Szczecin, Poland
CORRESPONDING AUTHOR
Wojciech Lubiński   

2nd Department of Ophthalmology, Pomeranian Medical University in Szczecin
 
Ann Agric Environ Med. 2018;25(3):443–448
KEYWORDS
TOPICS
ABSTRACT
Objective:
The aim of the study is to analyse correlations between age-related cataract (ARC), serum selenium levels and glutathione peroxidase gene 1 and 4 (GPX-1 and GPX-4).

Material and methods:
A total sample of 275 participants were enrolled into the study: group A, 94 subjects elligible for ARC surgery, and group B, 181 volunteers without ocular symptoms, gender-, age-, and smoking- status and volume-matched at 1:2 with subjects in group A. All participants (n=275) were divided according to the Lens Opacities Classification System III (LOCS III) into: 1) study group (subjects with clinically significant cataract; N≥3 or C≥3 or P≥2), 2) control group (controls with clinically non-significant cataract; N<3 and C<3 and P<2). The single nucleotide polymorphisms of GPX-1 and GPX-4 were assessed using Real Time PCR. Serum selenium levels were assayed using Inductively Coupled Plasma Mass Spectrometry.

Results:
Low selenium levels significantly predicted any age-related cataract (OR 7.969; p<.01), nuclear cataract (OR 12.823; p<.01) and cortical cataract (OR 3.31; p<.01). There was no significant effect of gender, age, SNP GPX-1 and SNP GPX-4 on the prevalence of age-related nuclear, cortical and posterior sub-capsular cataract. Serum selenium levels of 75–85 µg/L were associated with the lowest prevalence of ARC.

Conclusions:
Due to a confirmed association between serum selenium levels and age-related cataract, low serum selenium levels may constitute a potential risk factor of age-related cataract.

 
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