CASE REPORT
Reactive thrombocytosis resulting from frequent blood donations as an extremely rare cause of ST Segment Elevation Myocardial Infarction in the case of a 19-year-old male
 
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1
Doctoral Studies, II Faculty of Medicine with English Languae Divison, Medical University of Lublin
 
2
Chair and Department of Cardiology, Medical University of Lublin
 
 
Corresponding author
Andrzej Jakub Sałacki   

Doctoral Studies, II Faculty of Medicine with English Languae Divison, Medical University of Lublin, Organowa, 8/23, 20-882 Lublin, Poland
 
 
Ann Agric Environ Med. 2018;25(4):602-604
 
KEYWORDS
TOPICS
ABSTRACT
Introduction:
Thrombocytosis is a disease where the platelet count exceeds 600,000/μl. It is usually reactive in nature, less often clonal. Reactive thrombocytosis is usually a response to reactive inflammation or infection, splenectomy, iron deficiency, pregnancy, physical effort or cancer.

Case Report:
The case is described of a heart attack with ST-segment elevation in a 19-year-old male which was occurred due to intensive haematopoietic system renewal, caused by frequent blood donation which, in turn, caused reactive thrombocytosis. Reactive thrombocytosis is very rarely the cause of heart attack with ST-segment elevation, and is extremely rarely caused by blood donation. It is generally considered that reactive thrombocytosis is not a risk factor in the case of thromboembolic complications.

Conclusion:
The presented case and the literature point to the risk of serious thromboembolic incidents, including heart attack, in the course of thrombocytosis.

 
REFERENCES (19)
1.
Aundhakar SC, Mahajan SK, Mane MB, Lakhotiya AN. Reactive thrombocytosis leading to acute myocardial infarction. J Assoc Physicians India. 2013; 61: 745–747.
 
2.
Tefferi A, Hanson CA, Inwards DJ. How to interpret and pursue an abnormal complete blood cell count in adults. Mayo Clin Proc. 2005; 80: 923–936.
 
3.
Schafer AI. Thrombocytosis. N Engl J Med. 2004; 350: 1211–1219.
 
4.
Sułek K. 1000 practical questions in hematology. Publishers 7 i pół. 1996; 8: 151–155.
 
5.
Kelly SV, Burke RF, Lee KS, Torloni AS, Lee RW, Northfelt D, et al. Acute myocardial infarction: An unusual presentation of essential thrombocytosis in a 17- year-old man. Clin Adv Hematol Oncol. 2008; 6: 133–136.
 
6.
Vannucchi AM, Barbui T. Thrombocytosis and thrombosis. Hematology Am Soc Hematol Educ Program. 2007; 1: 363–370.
 
7.
Scheffer MG, Michiels JJ, Simoons ML, Roelandt JRTC. Thrombocythemia and coronary artery disease. Am Heart J. 1991; 122: 573–576.
 
8.
Dmoszyńska A, Robak T, Hus I. Basic hematology. 3rd edition. Czelej 2015.
 
9.
Williams B, Morton C. Cerebral vascular accident in a patient with reactive thrombocytosis: A rare cause of stroke. Am J Med Sci. 2008; 336: 279–281.
 
10.
Griesshammer M, Bangerter M, Sauer T, Wennauer R, Bergmann L, Heimpel H. Aetiology and clinical significance of thrombocytosis: Analysis of 732 patients with an elevated platelet count. J Intern Med. 1999; 245: 295–300.
 
11.
Boxer MA, Braun J, Ellmann L. Thromboembolic risk of postsplenectomy thrombocytosis. Arch Surg. 1978; 113:808–809.
 
12.
Buss DH, Stuart JJ, Lipscomb GE. The incidence of thrombotic and hemorrhagic disorders in association with extreme thrombocytosis: An analysis of 129 cases. Am J Hematol. 1985; 20: 365–372.
 
13.
Tai YT, Yu YL, Lau CP, Fong PC. Myocardial infarction complicating post splenectomy thrombocytosis, with early left ventricular mural thrombus formation and cerebral embolism: A case report. Angiology. 1993; 44: 73–77.
 
14.
Nielsen H. Fatal acute myocardial infarction associated with post splenectomy thrombocytosis. Ugesker Laeger. 1988; 150: 2125–2126.
 
15.
Aundhakar SC, Mahajan SK, Mane MB, Lakhotiya AN. Reactive thrombocytosis leading to acute myocardial infarction. J Assoc Physicians India. 2013.
 
16.
Ghaffari S, Pourafkari L. Acute myocardial infarction in a patient with post-splenectomy thrombocytosis: A case report and review of literature. Cardiol J. 2010; 17: 79–82.
 
17.
Dumrongmongcolgul N, Mankongpaisarnrung C, Sutamtewagul G, Hosiriluck N, Chen T, Trujillo, et al. Reactive Thrombocytosis Associated with Acute Myocardial Infarction following STEMI with Percutaneous Coronary Intervention. Case Rep Cardiol. 2013.
 
18.
Lewis SM. The spleen. In: Hoffbrand AV, Catovsky D, Tuddenham EG, editors. Postgraduate hematology. 5th Ed. Blackwell Publishing, Oxford 2005: 364.
 
19.
Williams B, Morton C. Cerebral vascular accident in a patient with reactive thrombocytosis: A rare cause of stroke. Am J Med Sci. 2008.
 
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