The Lyme Disease Action (LDA) is a leading English non-profit organization for combat borreliosis in Europe. LDA is well known for bringing together medical staff, academic researchers, and patients with vector-borne diseases, especially tick-borne diseases. LDA additionally collects and shares information about Lyme disease and organizes conferences in this field. Lyme Disease Action's first three UK Conferences on Tick-Borne Diseases, held in 2001, 2003 and 2004, have resulted in a considerable improvement in the understanding and treatment of many tick-connected conditions. IV Lyme Disease Action Conference was held on 17-18 June 2005 in Halifax Hall, University of Sheffield, UK. I had the pleasure to give a lecture on Borreliosis and Nervous System. In addition to myself, 10 lecturers and several medical professionals, patients and caregivers had an opportunity to speak and learn about Lyme borreliosis.