ORIGINAL ARTICLES

AAEM

Ann Agric Environ Med 2005, 12, 177-179

EFFECT OF PESTICIDES ON KYNURENIC ACID
PRODUCTION IN RAT BRAIN SLICES

Elzbieta Zielinska1, Tomasz Kocki2, Tomasz Saran1, Sandor Borbely3,
Damian Kuc2, Ildiko Vilagi3, Ewa M. Urbanska1, 2, Waldemar A. Turski1, 2

1Department of Toxicology, Institute of Agricultural Medicine, Lublin, Poland
2Department of Pharmacology and Toxicology, Medical University, Lublin, Poland
3Department of Physiology and Neurobiology, Eotvos Lorand University, Budapest, Hungary

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Zielinska E, Kocki T, Saran T, Borbely S, Kuc D, Vilagi I, Urbanska EM, Turski WA: Effect of pesticides on kynurenic acid production in rat brain slices. Ann Agric Environ Med 2005, 12, 177-179.

Abstract: Kynurenic acid (KYNA) is a broad spectrum antagonist of ionotropic glutamate receptors, preferentially active at the strychnine-insensitive glycine allosteric site of the N-methyl-D-aspartate (NMDA) receptor, and a noncompetitive antagonist of alpha7 nicotinic receptor. Animal studies showed that it possesses anticonvulsant and neuroprotective properties. Its involvement in the pathophysiology of various brain disorders was suggested. In this study, the effect of pesticides on KYNA production in brain cortical slices was investigated. Pyrethroids, deltamethrin and fenpropathrin significantly lowered KYNA production. Methomyl, bensultap, fipronil, diquat and MCPA were ineffective in this regard. In view of this data, the inhibition of KYNA synthesis appear to merit further investigation as a potential factor contributing to the toxicology of pyrethroids.

Address for correspondence: Waldemar Turski, Department of Pharmacology and Toxicology, Medical University, Jaczewskiego 8, 20-090 Lublin, Poland. E-mail: waldemar.turski@am.lublin.pl

Key words: kynurenic acid, pesticide, rat brain slices.


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