ORIGINAL ARTICLES

AAEM

Ann Agric Environ Med 2003, 10, 87-91

COMPARISON OF HISTOLOGICAL AND ULTRASTRUCTURAL CHANGES IN MICE
ORGANS AFTER SUPPLEMENTATION WITH INORGANIC AND ORGANIC
SELENIUM

Sabina Tos-Luty1, Daniela Obuchowska-Przebirowska1, Jadwiga Latuszynska1, Irena Musik2,
Malgorzata Tokarska-Rodak1

1Department of Pathomorphology, Institute of Agricultural Medicine, Lublin, Poland
2Chemistry Department, University Medical School, Lublin, Poland

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Tos-Luty S, Obuchowska-Przebirowska D, Latuszynska J, Musik I, Tokarska-Rodak M: Comparison of histological and ultrastructural changes in mice organs after supplementation with inorganic and organic selenium. Ann Agric Environ Med 2003, 10, 87-91.

Abstract: Two organic compounds of selenium, 4-o-totyl-selenosemicarbazide p-chlorobenzoic acid (chain compound) produced at the Chemistry Department of the University Medical School in Lublin, and one inorganic compound of sodium IV selenite (Na2SeO3) were used. The preparations were used per os in doses of 1 mg/kg body weight and 0.5 mg/kg body weight. The studies were conducted on female Swiss mice, covering seven groups of animals, i.e. 6 experimental and 1 control. Histopathologic changes were observed in liver, kidney, lung and heart. Ultrastructural changes were observed in liver and kidney. Our studies indicate a dose-dependent effect of selenium on histopathologic and ultrastructural changes. It is possible therefore, that the extent of excess of selenium exerts a greater influence on a cell than the form of supplemented selenium.

Address for correspondence: Prof. Sabina Tos-Luty, PhD, Head of the Department of Pathomorphology, Institute of Agricultural Medicine, P.O.Box 185, 20-950 Lublin, Poland

Key words: Inorganic selenium, organic selenium, oral application, histopathology, ultrastructure, rats.


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