TY - JOUR JO - Annals of Agricultural and Environmental Medicine J2 - Ann Agric Environ Med. SN - 1232-1966 VL - 21 IS - 3 PY - 2014 ID - Rzymski2014 TI - The interaction between menstrual cycle, Tumour Necrosis Factor alpha receptors and sex hormones in healthy non-obese women – results from an observational study AB - There is growing evidence that TNF-alpha and its two receptors play an important role in hormonal regulation, metabolism, inflammation and cancer. The biological effects of TNF-alpha are mediated by two receptors, p55 and p75. The aim of this study was to analyze serum concentrations of p55 and p75 and hormonal status in healthy women during the normal menstrual cycle. Eight women aged 20–22 with regular menstrual cycles were scheduled for examination on 3 rd , 8 th , 14 th and 25 th day of their menstrual cycle. We only observed a positive correlation of p75 subunit with prolactin level (correlation coefficient 0.417; p=0.0116) and negative correlation with insulin level (correlation coefficient -0.35; p=0.032) and HOMA IR insulin resistance index correlation coefficient 0.39; p=0.0185). Furthermore, a negative correlation of p55/p75 ratio with prolactin (correlation coefficient -0.42; p=0.0101) and a positive correlations of p55/p75 ratio with insulin level (correlation coefficient 0.43; p=0.008) and HOMA IR insulin resistance factor correlation coefficient 0.45; p=0.0065) were found. AU - Rzymski, Paweł AU - Wilczak, Maciej AU - Malinger, Anna AU - Włoszczak-Szubzda, Anna AU - Jarosz, Mirosław J. AU - Opala, Tomasz SP - 571 EP - 575 DA - 2014 DO - 10.5604/12321966.1120604 UR - https://doi.org/10.5604/12321966.1120604 ER -