RESEARCH PAPER
Influence of environment on residence and selected demographic and clinical parameters of preschool children with IgE-dependent asthma
1
Department of Paediatric Nursing, Faculty of Health Sciences, Medical University, Lublin, Poland
2
Department of Clinical Pathomorphology, Medical University, Lublin, Poland
3
Chair and Department of Periodontology, Medical University, Lublin, Poland
4
Department of Neuro-Rehabilitation, Institute of Rural Health, Lublin, Poland
5
Department of Pulmonary Diseases and Children Rheumatology, Medical University, Lublin, Poland
Corresponding author
Anna Bednarek
Department of Pediatric Nursing, Faculty of Health Sciences, Medical University of Lublin
Department of Pediatric Nursing, Faculty of Health Sciences, Medical University of Lublin
Ann Agric Environ Med. 2019;26(3):439-444
KEYWORDS
TOPICS
ABSTRACT
Introduction and objective:
An important role in the pathogenesis of asthma in children is played by individual parameters and environmental factors, in particular, those related to the place of residence. The aim of this study was to assess the impact of the living environment on the basic demographic and clinical parameters of preschool children with IgE-dependent asthma.
Material and methods:
176 children (126 from urban and 52 from rural areas) aged 5.22±0.34 years, with newly-diagnosed IgE-dependent asthma, hospitalised at the Clinic for Lung Diseases and Paediatric Rheumatology of the Prof. Antoni Gębala Children’s Hospital of Lublin, were qualified for the study. Medical documentation of the children was analysed, including the implementation of vaccinations. Due to the clinical form of the disease, patients were separated into groups with mild, moderate and severe asthma.
Results:
No statistically significant differentiation was observed between age and current body weight and height of the children. Similarly, gender and the clinical form of asthma were not significantly correlated with the place of residence. Children with asthma, at the time of exacerbation symptoms of the disease, living in a city, significantly more often (p <0.05) were treated with antibiotics in the hospital during hospitalization, while the value of OR (5.08) indicated that the rural environment enforces more frequent use of OGCs during asthma exacerbation therapy. In children from the urban environment, there was a significant correlation between the current body weight and serum calcium concentration, as well as a negative statistically significant correlation between the current body weight and serum selenium concentration.
Conclusions:
Residence does not determine the clinical course of IgE-dependent asthma in preschool children.
An important role in the pathogenesis of asthma in children is played by individual parameters and environmental factors, in particular, those related to the place of residence. The aim of this study was to assess the impact of the living environment on the basic demographic and clinical parameters of preschool children with IgE-dependent asthma.
Material and methods:
176 children (126 from urban and 52 from rural areas) aged 5.22±0.34 years, with newly-diagnosed IgE-dependent asthma, hospitalised at the Clinic for Lung Diseases and Paediatric Rheumatology of the Prof. Antoni Gębala Children’s Hospital of Lublin, were qualified for the study. Medical documentation of the children was analysed, including the implementation of vaccinations. Due to the clinical form of the disease, patients were separated into groups with mild, moderate and severe asthma.
Results:
No statistically significant differentiation was observed between age and current body weight and height of the children. Similarly, gender and the clinical form of asthma were not significantly correlated with the place of residence. Children with asthma, at the time of exacerbation symptoms of the disease, living in a city, significantly more often (p <0.05) were treated with antibiotics in the hospital during hospitalization, while the value of OR (5.08) indicated that the rural environment enforces more frequent use of OGCs during asthma exacerbation therapy. In children from the urban environment, there was a significant correlation between the current body weight and serum calcium concentration, as well as a negative statistically significant correlation between the current body weight and serum selenium concentration.
Conclusions:
Residence does not determine the clinical course of IgE-dependent asthma in preschool children.
REFERENCES (36)
1.
Federico MJ, Hoch HE, Anderson WC, Spahn JD, Szefler SJ. Asthma Management for Children Risk Identification and Prevention. Advances in Pediatrics 2016; 63: 103–126.
2.
Hatzler L, Hofmaier S, Papadopoulos NG. Allergic airway diseases in childhood – marching from epidemiology to novel concepts of prevention. Pediatr Allergy Immunol. 2012; 23: 616–622.
3.
Han MK, Agusti A, Calverley PM, Celli BR, Criner G, Curtis JL, et al. Chronic obstructive pulmonary disease phenotypes. The future of COPD. Am J Respir Crit Care Med. 2010; 182: 598–604.
4.
Tagiyeva N, Devereux G, Fielding S, Turner S, Douglas G. Outcomes of childhood asthma and wheezy bronchitis – a 50-year cohort study. Am J Respir Crit Care Med. 2016; 193: 23–30.
5.
World Health Organization. Technical Briefing. Asthma and COPD interventions for the Appendix 3 of the Global Action Plan for Non Communicable Disease. Geneva, 2017.
6.
Szefler SJ, Gergen PJ, Mitchell H, Morgan W. Achieving asthma control in the inner city: do the National Institutes of Health Asthma Guidelines really work? J Allergy Clin Immunol. 2010; 125(3): 521–6.
7.
Guilbert TW, Mauger DT, Lemanske RF. Childhood asthma – predictive phenotype. J Allergy Clin Immunol Pract. 2014; 2: 664–70.
8.
Jutel M. Rozpoznawanie chorób alergicznych w podstawowej opiece zdrowotnej. Podsumowanie zaleceń grupy ekspertów EAACI 2014 (The diagnosis of allergic diseases in primary health care. Summary of the recommendations of the EAACI 2014 expert group). Med Prakt. 2014; 7–8: 60–68 [in Polish].
9.
Bowatte G, Lodge C, Lowe AJ, Erbas B, Perret J, Abramson MJ, et al. The influence of childhood traffic-related air pollution exposure on asthma, allergy and sensitization: a systematic review and a meta-analysis of birth cohort studies. Allergy 2015; 70: 245–256.
10.
Brunst KJ, Ryan PH, Brokamp C, Bernstein D, Reponen T, Lockey J, et al. Timing and Duration of Trafficrelated Air Pollution Exposure and the Risk for Childhood Wheeze and Asthma. Am J Respir Crit Care Med. 2015; 192: 421–427.
11.
Jung DY, Leem JH, Kim HC, Kim JH, Hwang SS, Lee JY, et al. Effect of Traffic-Related Air Pollution on Allergic Disease: Results of the Children’s Health and Environmental Research. Allergy Asthma Immunol Res. 2015; 7: 359–366.
12.
Huang S, Wang JH, Huang SK, Yan L, Lan L, Hong J, et al. Survey on the correlation factors of the pathogenesis of asthma in children in Guangzhou community. J Practical Med. 2010; 26: 3240–3.
13.
Koczulla AR, Vogelmeier CF, Garn H, Renz H. New concepts in asthma: clinical phenotypes and pathophysiological mechanisms. Drug Discov Today 2017; 22(2): 388–96.
14.
Castro-Rodriguez JA, Holberg CJ, Wright AL, Martinez FD. A clinical index to define risk of asthma in young children with recurrent wheezing. Am J Respir Crit Care Med. 2000; 162: 1403–6.
15.
Global Strategy for Asthma management and prevention, Global Initiative for Asthma (GINA) Update 2008. http://www.ginasthma.org
16.
Chung KF, Wenzel SE, Brozek JL, Bush A, Castro M, Sterk PJ, et al. International ERS/ATS guidelines on definition, evaluation and treatment of severe asthma. Eur Respir. 2014; 43: 343–373.
17.
Li M, Zhang Q, Shi WJ, Li L, Yan L, Ying P, et al. Epidemiological survey and analysis of asthma in children aged 0–14 years old in urban and rural areas of Chengdu region. Transl Pediatr. 2013; 2(4): 160–166.
18.
Hagan JB, Samant SA, Volcheck GW, Li JT, Hagan CR, Erwin PJ, et al. The risk of asthma exacerbation after reducing inhaled corticosteroids: a systemic review and meta-analysis of randomized controlled trials. Allergy 2014; 69: 510–516.
19.
Genuneit J. Exposure to farming environments in childhood and asthma and wheeze in rural populations: a systematic review with meta-analysis. Pediatr Allergy Immunol. 2012; 23: 509–518.
20.
von Mutius E. The microbial environment and its influence on asthma prevention in early life. J Allergy Clin Immunol. 2016; 137: 680–9.
21.
Heinrich J. Influence of indoor factors in dwellings on the development of childhood asthma. J Hyg Environ Health. 2011; 214(1): 1–25.
22.
Brandt EB, Biagini Myers JM, Ryan PH, Khurana Hershey GK. Air pollution and allergic diseases. Curr Opin Pediatr. 2015; 27: 724–735.
23.
Braback L, Forsberg B. Does traffic exhaust contribute to the development of asthma and allergic sensitization in children: findings from recent cohort studies. Environ Health 2009; 8: 17–28.
24.
Brunst KJ, Ryan PH, Brokamp C, Bernstein D, Reponen T, Lockey J, et al. Timing and Duration of Trafficrelated Air Pollution Exposure and the Risk for Childhood Wheeze and Asthma. Am J Respir Crit Care Med. 2015; 192: 421–427.
25.
Jackson DJ, Gern JE, Lemanske RF Jr. The contributions of allergic sensitization and respiratory pathogens to asthma inception. J Allergy Clin Immunol. 2016; 137: 659–65.
26.
Ierodiakonou D, Zanobett A, Coull BA, Melly S, Postma DS, Boezen HM, et al. Ambient air pollution, lung function and airway responsiveness in asthmatic children. J Allergy Clin Immunol. 2016; 137: 390–9.
27.
von Mutius E. The microbial environment and its influence on asthma prevention in early life. J Allergy Clin Immunol. 2016; 137: 68–9.
28.
Pegas PN, Alves CA, Scotto MG, Evtyugina MG, Pio CA, Freitas MC. Risk factors and prevalence of asthma and rhinitis among primary school children in Lisbon. Rev Port Pneumol. 2011; 17(3): 109–116.
29.
Hoffmann PR. Asthma in children and nutritional selenium get another look. Clin Exp Allergy. 2011; 42: 488–489.
30.
Fernanda M, Carneiro H, Rhoden CR, Amantéa SL, Barbosa F. Low Concentrations of Selenium and Zinc in Nails are Associated with Childhood Asthma. Biol Trace Elem Res. 2011; 144: 244–252.
31.
Jacobson GA, Yee KC, Ng CH. Elevated plasma glutathione peroxidase concentration in acute severe asthma: comparison with plasma glutathione peroxidase activity, selenium and malondialdehyde. Scand J Clin Lab Invest. 2007; 67: 423–430.
32.
Lezmi G, Gosset P, Deschildre A, Abou-Taam R, Mahut B, Beydon N, et al. Airway remodeling in preschool children with severe recurrent wheeze. Am J Respir Crit Care Med. 2015; 192: 164–71.
33.
Anderson WC III, Szefler SJ. New and future strategies to improve asthma control in children. J Allergy Clin Immunol. 2015; 136(4): 848–59.
34.
Oluwole O, Arinola OG, Adu MD, Adepoju A, Adedokun BO, Olopade OI, et al. Relationships between Plasma Micronutrients, Serum IgE, and Skin Test Reactivity and Asthma among School Children in Rural Southwest Nigeria. J Mol Biomark Diagn. 2014; ID 106150: 1–9.
35.
Ly NP, Gold DR, Weiss ST, Celedon JC. Recurrent wheeze in early childhood and asthma among children at risk for atopy. Pediatrics. 2006; 117: e1132–1138.
36.
Bednarek A, Bodajko-Grochowska A, Bartkowiak-Emeryk M, Klepacz R, Ciółkowski J, Zarzycka D, Emeryk A. Demographic and medical factors affecting short-term changes in subjective evaluation of asthma control in adolescents. Post Dermatol Alergol. 2018; 35, 3: 259–266.
Share
RELATED ARTICLE
| eISSN: | 1898-2263 |
| ISSN: | 1232-1966 |
Improvement of visual identification of the journal - task financed under the agreement No. 618/P-DUN/2019 by the Minister of Science and Higher Education allocated to the activities of disseminating science.
Generation of the DOI (Digital Object Identifier) - task financed under the agreement No. 618/P-DUN/2019 by the Minister of Science and Higher
© 2006-2024 Journal hosting platform by Bentus
We process personal data collected when visiting the website. The function of obtaining information about users and their behavior is carried out by voluntarily entered information in forms and saving cookies in end devices. Data, including cookies, are used to provide services, improve the user experience and to analyze the traffic in accordance with the Privacy policy. Data are also collected and processed by Google Analytics tool (more).
You can change cookies settings in your browser. Restricted use of cookies in the browser configuration may affect some functionalities of the website.
You can change cookies settings in your browser. Restricted use of cookies in the browser configuration may affect some functionalities of the website.
