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REVIEW PAPER
 
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Streptococcus suis: a re-emerging pathogen associated with occupational exposure to pigs or pork products. Part I – Epidemiology

Jacek Dutkiewicz 1  ,  
Jacek Sroka 1, 2,  
Ewa Cisak 1,  
Anna Sawczyn 1,  
Anna Kloc 1,  
 
1
Department of Biological Health Hazards and Parasitology, Institute of Rural Health, Lublin, Poland
2
Department of Parasitology, National Veterinary Research Institute, Puławy, Poland
3
Department of Hygiene of Food of Animal Origin, National Veterinary Research Institute, Puławy, Poland
KEYWORDS:
TOPICS:
ABSTRACT:
Streptococcus suis (ex Elliot 1966, Kilpper-Bälz & Schleifer 1987) is a facultatively anaerobic Gram-positive ovoid or coccal bacterium surrounded by a polysaccharide capsule. Based on the antigenic diversity of the capsule, S. suis strains are classified serologically into 35 serotypes. Streptococcus suis is a commensal of pigs, commonly colonizing their tonsils and nasal cavities, mostly in weaning piglets between 4–10 weeks of age. This species occurs also in cattle and other mammals, in birds and in humans. Some strains, mostly those belonging to serotype 2, are also pathogenic for pigs, as well as for other animals and humans. Meningitis is the primary disease syndrome caused by S. suis, both in pigs and in humans. It is estimated that meningitis accounted for 68.0% of all cases of human disease reported until the end of 2012, followed by septicaemia (including life-threatening condition described as ‘streptococcal toxic shock-like syndrome’ – STSLS), arthritis, endocarditis, and endophthalmitis. Hearing loss and/or ves tibular dysfunction are the most common sequelae after recovery from meningitis caused by S. suis, occurring in more than 50% of patients. In the last two decades, the number of reported human cases due to S. suis has dramatically increased, mostly due to epidemics recorded in China in 1998 and 2005, and the fulminant increase in morbidity in the countries of south-eastern Asia, mostly Vietnam and Thailand. Out of 1,642 cases of S. suis infections identified between 2002–2013 worldwide in humans, 90.2% occurred in Asia, 8.5% in Europe and 1.3% in other parts of the globe. The human disease has mostly a zoonotic and occupational origin and occurs in pig breeders, abattoir workers, butchers and workers of meat processing facilities, veterinarians and meat inspectors. Bacteria are transmitted to workers by close contact with pigs or pig products, usually through contamination of minor cuts or abrasions on skin of hands and/or arms, or by pig bite. A different epidemiologic situation occurs in the Southeast Asian countries where most people become infected by habitual consumption of raw or undercooked pork, blood and offal products in the form of traditional dishes. Prevention of S. suis infections in pigs includes vaccination, improvement in pig-raising conditions, disinfection and/or fumigation of animal houses, and isolation of sick animals at the outbreak of disease. Prevention of human infections comprises: protection of skin from pig bite or injury with sharp tools by people occupationally exposed to pigs and pig products, prompt disinfection and dressing of wounds and abrasions at work, protection of the respiratory tract by wearing appropriate masks or repirators, consulting a doctor in the case of febrile illness after exposure to pigs or pork meat, avoidance of occupations associated with exposure to pigs and pork by immunocompomised people, avoidance of consumption of raw pork or pig blood, adequate cooking of pork, and health education.
CORRESPONDING AUTHOR:
Jacek Dutkiewicz   
Department of Biological Health Hazards and Parasitology, Institute of Rural Health, Lublin, Poland, Jaczewskiego 2, 20-090 Lublin, Poland
 
REFERENCES (103):
1. Higgins R, Gottschalk M. An update on Streptococcus suis identification. J Vet Diagn Invest. 1990; 2: 249–252.
2. Tarradas C, Arenas A, Maldonado A, Luque I, Miranda A, Perea A. Identification of Streptococcus suis isolated from swine: proposal for biochemical parameters. J Clin Microbiol. 1994; 32: 578–580.
3. Staats JJ, Feder I, Okwumabua O, Chengappa MM. Streptococcus suis: past and present. Vet Res Commun. 1997; 21(6): 381–407.
4. Lun ZR, Wang QP, Chen XG, Li AX, Zhu XQ. Streptococcus suis: an emerging zoonotic pathogen. Lancet Infect Dis. 2007; 7(3): 201–209.
5. Goyette-Desjardins G, Auger JP, Xu J, Segura M, Gottschalk M. Streptococcus suis, an important pig pathogen and emerging zoonotic agent-an update on the worldwide distribution based on serotyping and sequence typing. Emerg Microbes Infect. 2014; 3(6):e45. doi: 10.1038/emi.2014.45.
6. Field HI, Buntain D, Done JT. Studies on pig mortality. I. Streptococcal meningitis and arthritis. Vet Rec. 1954; 66: 453–435.
7. Segura M, Calzas C, Grenier D, Gottschalk M. Initial steps of the pathogenesis of the infection caused by Streptococcus suis: fighting against nonspecific defenses. FEBS Lett. 2016; 590(21): 3772–3799.
8. Hommez J, Wullepit J, Cassimon P, Castryck F, Ceyssens K, Devriese LA. Streptococcus suis and other streptococcal species as a cause of extramammary infection in ruminants. Vet Rec. 1988; 123(24): 626–627.
9. Devriese LA, Haesebrouck F, de Herdt P, Dom P, Ducatelle R, Desmidt M, Messier S, Higgins R. Streptococcus suis infections in birds. Avian Pathol. 1994; 23(4): 721–724.
10. Okwumabua O, Peterson H, Hsu HM, Bochsler P, Behr M. Isolation and partial characterization of Streptococcus suis from clinical cases in cattle. J Vet Diagn Invest. 2017; 29(2): 160–168.
11. Perch B, Kristjansen P, Skadhauge K. Group R streptococci pathogenic for man: two cases of meningitis and one fatal case of sepsis. Acta Pathol Microbiol Scand. 1968; 74: 69–76.
12. Arends JP, Zanen HC. Meningitis caused by Streptococcus suis in humans. Rev Infect Dis. 1988; 10(1): 131–137.
13. Van Samkar A, Brouwer MC, Schultsz C, van der Ende A, van de Beek D. Streptococcus suis meningitis: a systematic review and meta-analysis. PLoS Negl Trop Dis. 2015 Oct 27; 9(10): e0004191. doi: 10.1371/journal.pntd.0004191.
14. Feng Y, Zhang H, Wu Z, Wang S, Cao M, Hu D, Wang C. Streptococcus suis infection: an emerging/reemerging challenge of bacterial infectious diseases? Virulence. 2014; 5(4): 477–497.
15. Segura M, Zheng H, de Greeff A, Gao GF, Grenier D, Jiang Y et al. Latest developments on Streptococcus suis: an emerging zoonotic pathogen: part 1. Future Microbiol. 2014; 9(4): 441–444.
16. Segura M, Zheng H, de Greeff A, Gao GF, Grenier D et al. Latest developments on Streptococcus suis: an emerging zoonotic pathogen: part 2. Future Microbiol. 2014; 9(5): 587–591.
17. Huong VT, Ha N, Huy NT, Horby P, Ho DTN, Thiem VD, Zhu X, Hoa NT, Hien TT, Zamora J et al. Epidemiology, clinical manifestations, and outcomes of Streptococcus suis infection in humans. Emerg Infect Dis. 2014; 20(7): 1105–1114.
18. Pappas G. Socio-economic, industrial and cultural parameters of pig-borne infections. Clin Microbiol Infect. 2013; 19(7): 605–610.
19. Djurković-Djaković O, Bobić B, Nikolić A, Klun I, Dupouy-Camet J. Pork as a source of human parasitic infection. Clin Microbiol Infect. 2013; 19(7): 586–594.
20. Fittipaldi N, Segura M, Grenier D, Gottschalk M. Virulence factors involved in the pathogenesis of the infection caused by the swine pathogen and zoonotic agent Streptococcus suis. Future Microbiol. 2012; 7(2): 259–79.
21. Ma Y, Feng Y, Liu D, Gao GF. Avian influenza virus, Streptococcus suis serotype 2, severe acute respiratory syndrome-coronavirus and beyond: molecular epidemiology, ecology and the situation in China. Philos Trans R Soc Lond B Biol Sci. 2009; 364(1530): 2725–2737.
22. Hardie JM, Whiley RA. The genus Streptococcus. In: Wood B.J.B., Holzapfel W.H. (Eds.): The Lactic Acid Bacteria, Vol. II. Genera of Lactic Acid Bacteria. Springer Dordrecht, 1995, pp. 55–124.
23. Vos P, Garrity G, Jones D, Krieg NR, Ludwig W, Rainey FA, Schleifer K-H, Whitman W. Bergey’s Manual of Systematic Bacteriology: Vol. 3: The Firmicutes. Springer Dordrecht, Heidelberg, London, New York 2009.
24. Okura M, Osaki M, Nomoto R, Arai S, Osawa R, Sekizaki T, Takamatsu D. Current taxonomical situation of Streptococcus suis. Pathogens. 2016; 5(3). pii: E45. doi: 10.3390/pathogens5030045.
25. Gottschalk M, Xu J, Calzas C, Segura M. Streptococcus suis: a new emerging or an old neglected zoonotic pathogen? Future Microbiol. 2010; 5(3): 371–391.
26. Ferrando ML, Willemse N, Zaccaria E, Pannekoek Y, van der Ende A, Schultsz C. Streptococcal adhesin P (SadP) contributes to Streptococcus suis adhesion to the human intestinal epithelium. PLoS One. 2017; 12(4): e0175639. doi: 10.1371/journal.pone.0175639.
27. Tramontana AR, Graham M, Sinickas V, Bak N. An Australian case of Streptococcus suis toxic shock syndrome associated with occupational exposure to animal carcasses. Med J Aust. 2008; 188(9): 538–539.
28. Wertheim HF, Nghia HD, Taylor W, Schultsz C. Streptococcus suis: an emerging human pathogen. Clin Infect Dis. 2009; 48(5): 617–625.
29. Ye C, Zheng H, Zhang J, Jing H, Wang L, Xiong Y, Wang W, Zhou Z, Sun Q, Luo X, Du H, Gottschalk M, Xu J. Clinical, experimental, and genomic differences between intermediately pathogenic, highly pathogenic, and epidemic Streptococcus suis. J Infect Dis. 2009; 199(1): 97–107.
30. Willemse N, Howell KJ, Weinert LA, Heuvelink A, Pannekoek Y, Wagenaar JA, Smith HE, van der Ende A, Schultsz C. An emerging zoonotic clone in the Netherlands provides clues to virulence and zoonotic potential of Streptococcus suis. Sci Rep. 2016; 6:28984. doi: 10.1038/srep28984.
31. Wang J, Feng Y, Wang C, Zheng F, Hassan B, Zhi L, Li W, Yao Y, He E, Jiang S, Tang J, Price C, et al. Genome-wide analysis of a avirulent and reveal the strain induces protective immunity against challenge with virulent Streptococcus suis Serotype 2. BMC Microbiol. 2017; 17(1): 67. doi: 10.1186/s12866–017–0971–0.
32. Holden MT, Hauser H, Sanders M, Ngo TH, Cherevach I, Cronin A, Goodhead I, Mungall K, Quail MAI, Price C, et al. Rapid evolution of virulence and drug resistance in the emerging zoonotic pathogen Streptococcus suis. PLoS One. 2009; 4(7):e6072. doi: 10.1371/journal.pone.0006072.
33. Berthelot-Hérault F, Gottschalk M, Labbé A, Cariolet R, Kobisch M. Experimental airborne transmission of Streptococcus suis capsular type 2 in pigs. Vet Microbiol. 2001; 82(1): 69–80.
34. Dekker N, Bouma A, Daemen I, Klinkenberg D, van Leengoed L, Wagenaar JA, Stegeman A. Effect of spatial separation of pigs on spread of Streptococcus suis serotype 9. PLoS One. 2013; 8(4):e61339.
35. Bonifait L, Veillette M, Létourneau V, Grenier D, Duchaine C. Detection of Streptococcus suis in bioaerosols of swine confinement buildings. Appl Environ Microbiol. 2014; 80(11): 3296–3304.
36. Gauthier-Levesque L, Bonifait L, Turgeon N, Veillette M, Perrott P, Grenier D, Duchaine C. Impact of serotype and sequence type on the preferential aerosolization of Streptococcus suis. BMC Res Notes. 2016; 9(1): 273. doi: 10.1186/s13104–016–2073–8.
37. Madsen LW, Bak H, Nielsen B, Jensen HE, Aalbaek B, Riising HJ. Bacterial colonization and invasion in pigs experimentally exposed to Streptococcus suis serotype 2 in aerosol. J Vet Med B Infect Dis Vet Public Health. 2002; 49(5): 211–215.
38. Gottschalk M, Segura M, Xu J. Streptococcus suis infections in humans: the Chinese experience and the situation in North America. Anim Health Res Rev. 2007; 8(1): 29–45.
39. Fulde M, Valentin-Weigand P. Epidemiology and pathogenicity of zoonotic streptococci. Curr Top Microbiol Immunol. 2013; 368: 49–81.
40. Pejsak Z, Tarasiuk K, Sadoch L. Disease caused by Streptococcus suis type 2 in adult pigs in Poland. Medycyna Wet. 1989; 45: 525–528.
41. Papatsiros VG, Vourvidis D, Tzitzis AA, Meichanetsidis PS, Stougiou D, Mintza D, PS Papaioannou PS. Streptococcus suis: an important zoonotic pathogen for human – prevention aspects. Vet World. 2011; 4(5): 216–221.
42. Wang Y, Gagnon CA, Savard C, Music N, Srednik M, Segura M, Lachance C, Bellehumeur C, Gottschalk M. Capsular sialic acid of Streptococcus suis serotype 2 binds to swine influenza virus and enhances bacterial interactions with virus-infected tracheal epithelial cells. Infect Immun. 2013; 81(12): 4498–4508.
43. Hoa NT, Chieu TTB, Nga TTB, Van Dung N, Campbell J, Anh PH, Tho HH, Chau NVV, Bryant JE, Hien TT, Farrar J, Schultsz C. Slaughterhouse pigs are a major reservoir of Streptococcus suis serotype 2 capable of causing human infection in southern Vietnam. PLoS One. 2011; 6(3):e17943. doi: 10.1371/journal.pone.0017943.
44. Breton J, Mitchell WR, Rosendal S. Streptococcus suis in slaughter pigs and abattoir workers. Can J Vet Res. 1986; 50(3): 338–341.
45. Han DU, Choi C, Ham HJ, Jung JH, Cho WS, Kim J, Higgins R, Chae C. Prevalence, capsular type and antimicrobial susceptibility of Streptococcus suis isolated from slaughter pigs in Korea. Can J Vet Res. 2001; 65(3): 151–155.
46. Marois C, Le Devendec L, Gottschalk M, Kobisch M. Detection and molecular typing of Streptococcus suis in tonsils from live pigs in France. Can J Vet Res. 2007; 71(1): 14–22.
47. Meekhanon N, Kaewmongkol S, Phimpraphai W, Okura M, Osaki M, Sekizaki T, Takamatsu D. Potentially hazardous Streptococcus suis strains latent in asymptomatic pigs in a major swine production area of Thailand. J Med Microbiol. 2017; 66(5): 662–669.
48. Strojna S, Semka Z, Molenda J, Kozyrczak J, Janas P. Streptococcal meningitis in piglets. Med Wet. 1978; 34: 339–342.
49. Jiang X, Yang Y, Zhu L, Gu Y, Shen H, Shan Y, Li X, Wu J, Fang W. Live Streptococcus suis type 5 strain XS045 provides cross-protection against infection by strains of types 2 and 9. Vaccine. 2016; 34(51): 6529–6538.
50. Baums CG, Verkühlen GJ, Rehm T, Silva LM, Beyerbach M, Pohlmeyer K, Valentin-Weigand P. Prevalence of Streptococcus suis genotypes in wild boars of Northwestern Germany. Appl Environ Microbiol. 2007; 73(3): 711–717.
51. Devriese LA, Cruz Colque JI, De Herdt P, Haesebrouck F. Identification and composition of the tonsillar and anal enterococcal and streptococcal flora of dogs and cats. J Appl Bacteriol. 1992; 73(5): 421–425.
52. Cruz Colque JI, Devriese LA, Haesebrouck F. Streptococci and entero-cocci associated with tonsils of cattle. Lett Appl Microbiol. 1993; 16(2): 72–74.
53. Hayakawa Y, Komae H, Ide H, Nakagawa H, Yoshida Y, Kamada M, Kataoka Y, Nakazawa M. An occurrence of equine transport pneumonia caused by mixed infection with Pasteurella caballi, Streptococcus suis and Streptococcus zooepidemicus. J Vet Med Sci. 1993; 55(3): 455–456.
54. Kataoka Y, Sugimoto C, Nakazawa M, Morozumi T, Kashiwazaki M. The epidemiological studies of Streptococcus suis infections in Japan from 1987 to 1991. J Vet Med Sci. 1993; 55(4): 623–626.
55. Keymer IF, Heath SE, Wood JG. Streptococcus suis type II infection in a raccoon dog (Nyctereutes procyonoides) family Canidae. Vet Rec. 1983; 113(26–27): 624.
56. Ishigaki K, Nakamura A, Iwabuchi S, Kodera S, Ooe K, Kataoka Y, Aida Y. A case of Streptococcus suis endocarditis, probably bovine-transmitted, complicated by pulmonary embolism and spondylitis. Kansenshogaku Zasshi. 2009; 83(5): 544–548.
57. Bojarska A, Molska E, Janas K, Skoczyńska A, Stefaniuk E, Hryniewicz W, Sadowy E. Streptococcus suis in invasive human infections in Poland: clonality and determinants of virulence and antimicrobial resistance. Eur J Clin Microbiol Infect Dis. 2016; 35(6): 917–925.
58. Callejo R, Zheng H, Du P, Prieto M, Xu J, Zielinski G, Auger JP, Gottschalk M. Streptococcus suis serotype 2 strains isolated in Argentina (South America) are different from those recovered in North America and present a higher risk for humans. JMM Case Rep. 2016; 3(5): e005066. doi: 10.1099/jmmcr.0.005066.
59. Lecours MP, Segura M, Lachance C, Mussa T, Surprenant C, Montoya M, Gottschalk M. Characterization of porcine dendritic cell response to Streptococcus suis. Vet Res. 2011; 42:72. doi: 10.1186/1297-9716-42-72.
60. Ho DTN, Tu le TP, Wolbers M, Thai CQ, Hoang NV, Nga TV, Thao le TP, Phu NH, Chau TT, Sinh DX et al. Risk factors of Streptococcus suis infection in Vietnam. A case-control study. PLoS One. 2011; 6(3):e17604. doi: 10.1371/journal.pone.0017604.
61. Tang J, Wang C, Feng Y, Yang W, Song H, Chen Z, Yu H, Pan X, Zhou X, Wang H. et al. Streptococcal toxic shock syndrome caused by Streptococcus suis serotype 2. PLoS Med. 2006; 3(5):e151. DOI: 10.1371/journal.pmed.0030151.
62. Ye C, Zhu X, Jing H, Du H, Segura M, Zheng H, Kan B, Wang L, Bai X, Zhou Y, et al. State Key Streptococcus suis sequence type 7 outbreak, Sichuan, China. Emerg Infect Dis. 2006; 12(8): 1203–1208.
63. Feng Y, Zhang H, Ma Y, Gao GF. Uncovering newly emerging variants of Streptococcus suis, an important zoonotic agent. Trends Microbiol. 2010; 18(3): 124–131.
64. Gottschalk M. Porcine Streptococcus suis strains as potential sources of infections in humans: an underdiagnosed problem in North America? J Swine Health Prod. 2004; 12(4): 197–199.
65. Soares TC, Gottschalk M, Lacouture S, Megid J, Ribolla PE, Pantoja JC, Paes AC. Streptococcus suis in employees and the environment of swine slaughterhouses in São Paulo, Brazil: Occurrence, risk factors, serotype distribution, and antimicrobial susceptibility. Can J Vet Res. 2015; 79(4): 279–284.
66. Strangmann E, Fröleke H, Kohse KP. Septic shock caused by Streptococcus suis: case report and investigation of a risk group. Int J Hyg Environ Health. 2002; 205(5): 385–392.
67. Haleis A, Alfa M, Gottschalk M, Bernard K, Ronald A, Manickam K. Meningitis caused by Streptococcus suis serotype 14, North America. Emerg Infect Dis. 2009; 15(2): 350–352.
68. Domínguez-Punaro Mde L, Segura M, Contreras I, Lachance C, Houde M, Lecours MP, Olivier M, Gottschalk M. In vitro characterization of the microglial inflammatory response to Streptococcus suis, an important emerging zoonotic agent of meningitis. Infect Immun. 2010; 78(12): 5074–5085.
69. Robertson ID, Blackmore DK. Occupational exposure to Streptococcus suis type 2. Epidemiol Infect. 1989; 103(1): 157–164.
70. Barnham M. Pig bite injuries and infection: report of seven human cases. Epidem Inf. 1988; 101: 641–645.
71. Garduño E, Sánchez R, Sánchez R, Belón E, Lucio L, Martín P, Blanco J. Infection caused by pig bite. Enferm Infect Microbiol Clin. 1996; 14(5): 332–333.
72. Ejlertsen T, Gahrn-Hansen B, Søgaard P, Heltberg O, Frederiksen W. Pasteurella aerogenes isolated from ulcers or wounds in humans with occupational exposure to pigs: a report of 7 Danish cases. Scand J Infect Dis. 1996; 28(6): 567–570.
73. López C, Sanchez- Rubio P, Betrán A, Terré R. Pasteurella multocida bacterial meningitis caused by contact with pigs. Brazil J Microbiol. 2013; 44(2): 473–474.
74. Sriskandan S, Josh D. Slater JD. Invasive disease and toxic shock due to zoonotic Streptococcus suis: an emerging infection in the east? PLoS Med. 2006; 3(5): e187.
75. Sala V, Colombo A, Gerola L. Infection risks of Streptococcus suis type 2 localizations in slaughtered swines. Arch Vet It. 1989; 40: 180–184 (In Italian).
76. Rojas MT, Gottschalk M, Ordóñez VV. Evaluación de la virulencia y serotipos de Streptococcus suis aislados de trabajadores de rastros en el valle de Toluca, Estado de México, México. Vet Méx. 2001; 32: 201–205.
77. Smith TC, Capuano AW, Boese B, Myers KP, Gray GC. Exposure to Streptococcus suis among US swine workers. Emerg Infect Dis. 2008; 14(12): 1925–1927.
78. Elbers AR, Vecht U, Osterhaus AD, Groen J, Wisselink HJ, Diepersloot RJ, Tielen MJ. Low prevalence of antibodies against the zoonotic agents Brucella abortus, Leptospira spp., Streptococcus suis serotype II, hantavirus, and lymphocytic choriomeningitis virus among veterinarians and pig farmers in the southern part of The Netherlands. Vet Q. 1999; 21(2): 50–54.
79. Takeuchi D, Kerdsin A, Pienpringam A, Loetthong P, Samerchea S, Luangsuk P, Khamisara K, Wongwan N, Areeratana P, Chiranairadul P et al. Population-based study of Streptococcus suis infection in humans in Phayao Province in northern Thailand. PLoS One. 2012; 7(2):e31265. doi: 10.1371/journal.pone.0031265.
80. Watkins EJ, Brooksby P, Schweiger MS, Enright SM. Septicaemia in a pig-farm worker. Lancet. 2001; 357: 38.
81. Eisenberg T, Hudemann C, Hossain HM, Hewer A, Tello K, Bandorski D, Rohde M, Valentin-Weigand P, Baums CG. Characterization of five zoonotic Streptococcus suis strains from Germany, including one isolate from a Recent fatal case of streptococcal toxic shock-like syndrome in a hunter. J Clin Microbiol. 2015; 53(12): 3912–3915.
82. Willenburg KS, Sentochnik DE, Zadoks RN. Human Streptococcus suis meningitis in the United States. N Engl J Med. 2006; 354: 1325.
83. Fowler HN, Brown P, Rovira A, Shade B, Klammer K, Smith K, Scheftel J. Streptococcus suis meningitis in swine worker, Minnesota, USA. Emerg Infect Dis. 2013; 19(2): 330–331.
84. Gomez E, Kennedy CC, Gottschalk M, Cunningham SA, Patel R, Virk A. Streptococcus suis-related prosthetic joint infection and streptococcal toxic shock-like syndrome in a pig farmer in the United States. J Clin Microbiol. 2014; 52(6): 2254–2258.
85. Choi SM, Cho BH, Choi KH, Nam TS, Kim JT, Park MS, Kim BC, Kim MK, Cho KH. Meningitis caused by Streptococcus suis: case report and review of the literature. J Clin Neurol. 2012; 8: 79–82.
86. Taniyama D, Sakurai M, Sakai T, Kikuchi T, Takahashi T. Human case of bacteremia due to Streptococcus suis serotype 5 in Japan: The first report and literature review. IDCases. 2016; 6: 36–38.
87. Koch E, Fuentes G, Carvajal R, Palma R, Aguirre V, Cruz C, Henríquez R, Calvo M. Streptococcus suis meningitis in pig farmers: report of first two cases in Chile. Rev Chilena Infectol. 2013; 30(5): 557–561.
88. Zalas-Więcek P, Michalska A, Grabczewska E, Olczak A, Pawlowska M, Gospodarek E. Human meningitis caused by Streptococcus suis. J Med Microbiol. 2013; 62(Pt 3): 483–485.
89. Gustavsson C, Ramussen M. Septic arthritis caused by Streptococcus suis serotype 5 in pig farmer. Emerg Infect Dis. 2014; 20(3): 489–490.
90. Chatzopoulou M, Voulgaridou I, Papalas D, Vasiliou P, Tsiakalou M. Third case of Streptococcus suis infection in Greece. Case Rep Infect Dis. 2015; 2015:505834. doi: 10.1155/2015/505834.
91. Mancini F, Adamo F, Creti R, Monaco M, Alfarone G, Pantosti A, Ciervo A. A fatal case of streptococcal toxic shock syndrome caused by Streptococcus suis carrying tet (40) and tet (O/W/32/O), Italy. J Infect Chemother. 2016; 22(11): 774–776.
92. Rajahram GS, Hameed AA, Menon J, William T, Tambyah PA, Yeo TW. Case report: two human Streptococcus suis infections in Borneo, Sabah, Malaysia. BMC Infect Dis. 2017; 17(1):188. doi: 10.1186/s12879–017–2294-z.
93. Kopić J, Paradzik MT, Pandak N. Streptococcus suis infection as a cause of severe illness: 2 cases from Croatia. Scand J Infect Dis. 2002; 34(9): 683–684.
94. Lopreto C, Lopardo HA, Bardi MC, Gottschalk M. Primary Streptococcus suis meningitis: first case in humans described in Latin America. Enferm Infecc Microbiol Clin. 2005; 23(2): 110–112.
95. Manzin A, Palmieri C, Serra C, Saddi B, Princivalli MS, Loi G, Angioni G, Tiddia F, Varaldo PE, Facinelli B. Streptococcus suis meningitis without history of animal contact, Italy. Emerg Infect Dis. 2008; 14(12): 1946–1948.
96. Ho DTN, Hoa NT, Linh LD, Campbell J, Diep TS, Chau NVV, Mai NTH, Hien TT, Spratt B, Farrar J, Schultsz C. Human case of Streptococcus suis serotype 16 infection. Emerg Infect Dis. 2008; 14(1): 155–157.
97. Kim H, Lee SH, Moon H-W, Kim JY, Lee SH, Hur M, Yun Y-M. Streptococcus suis causes septic arthritis and bacteremia: phenotypic characterization and molecular confirmation. Korean J Lab Med. 2011; 31: 115–117.
98. Burniston S, Okello AL, Khamlome B, Inthavong P, Gilbert J, Blacksell SD, Allen J, Welburn SC. Cultural drivers and health-seeking behaviours that impact on the transmission of pig-associated zoonoses in Lao People’s Democratic Republic. Infect Dis Poverty. 2015; 4:11. doi: 10.1186/2049-9957-4-11.
99. Pejsak Z, Jabłoński A, Żmudzki J. Drug sensitivity of pathogenic bacteria isolated from the respiratory system of swine. Med Wet. 2005; 61: 664–668.
100. Szczotka A, Markowska-Daniel I, Pejsak Z. Antibiotic susceptibility of Polish Streptococcus suis isolates. Med Wet. 2007; 63: 1077–1080.
101. Lebel G, Piché F, Frenette M, Gottschalk M, Grenier D. Antimicrobial activity of nisin against the swine pathogen Streptococcus suis and its synergistic interaction with antibiotics. Peptides. 2013; 50: 19–23.
102. Jiao J, Mao R, Teng D, Wang X, Hao Y, Yang N, Wang, Feng X, Wang J. In vitro and in vivo antibacterial effect of NZ2114 against Streptococcus suis type 2 infection in mice peritonitis models. AMB Expr. 2017; 7(1):44. doi: 10.1186/s13568–017–0347–8.
103. White M. Pig health – streptococcal meningitis. NADIS (National Animal Disease Information Service) 2016. Available at: www.nadis.org.uk.
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