Evaluation of lipids, lipoproteins and apolipoproteins concentrations in cord blood serum of newborns from rural and urban environments
More details
Hide details
Department of Developmental Paediatrics, Medical University of Lublin, Poland
Elżbieta Pac-Kożuchowska   

Department of Developmental Paediatrics, Medical University of Lublin, 20-093 Lublin, ul. Chodźki 2,pOLAND
Ann Agric Environ Med. 2007;14(1):25–29
The purpose of the present study was to check the influence of rural and urban environments on some of the parameters of lipids metabolism in the cord blood serum in healthy newborns, as well as the evaluation of the concentration of lipids, lipoproteins and apolipoproteins in the cord blood serum with relation to risk factors of atherosclerosis in the family of the studied newborns. The study included 75 newborns (37 from rural areas and 38 from urban areas). Newborns weight and length were recorded at birth. On the basis of the family history taken from the mothers, the atherosclerosis risk factors were established in the families of the studied newborns. In all of the studied newborns, concentration of triglycerides, total cholesterol and LDL, VLDL and HDL cholesterol as well as of apolipoproteins (apo-AI, apo-B) in the cord blood serum sampled soon after birth were performed. No statistically significant differences between the mean levels of triglycerides, total cholesterol and cholesterol of fractions: LDL, VLDL, HDL and apolipoproteins (apo-AI, apo-B) in the cord blood serum in the newborns from rural and urban areas were found. However, when analysing the concentration of parameters of lipid metabolism in cord blood serum in newborns with regard to gender, higher concentrations of total cholesterol, LDL cholesterol and apo-AI in female newborns from rural areas, and higher HDL cholesterol and apo-AI in female newborns from urban regions were confi rmed. When analysing the concentration of lipids and lipoproteins in cord blood serum in newborns from families with risk factors confirmed as compared to the families without that risk, both in the rural and urban regions no significant differences were confi rmed. The studies have not proved any significant differences between the levels of lipids, lipoproteins and apolipoproteins in the cord blood serum in newborns from rural and urban areas.
Andersen GE: Changes in plasma lipoprotein from fi rst day to third week of human life. Prog Clin Biol Res 1985, 188, 87-91.
Bao W, Srinivasan SR, Wattigney WA, Berenson GS: Parental cardiovascular disease refl ected in risk factors of offspring. Cardiol Rev 1996, 1, 23-37.
Barker DJP: Growth in utero and coronary heart disease. Nutr Rev 1996, 54, S1-S7.
Barker DJP: In utero programming of cardiovascular disease. Theriogenology 2000, 2, 555-574.
Berenson GS, Wattigney WA, Tracy RE, Newman WP III, Srinivasan SR, Webber LS, Dalferes JrER, Strong JP: Atherosclerosis of the aorta and coronary arteries and cardiovascular risk factors in persons aged 6 to 30 years and studies at necropsy (The Bogalusa Heart Study). Am J Cardiol 1992, 70, 851-858.
Berenson GS: Cardiovascular health promotion for elementary school children. Czynniki Ryzyka 1998, Supl. 5, 11-13.
Boreham C, Twisk J, Van-Mechelen W, Savage M, Strain J, Cran G: Relationships between the development of biological risk factors for coronary heart disease and lifestyle parameters during adolescence: The Northern Ireland Young Hearts Project. Public Health 1999, 1, 7-12.
Buka SL, Brennan RT, Raudenbush SW, Earls F: Neighborhood support and the birth weight of urban infants. Am J Epidemiol 2003, 157, 1-8.
Chen J, Millar WJ: Heart disease, family history and physical activity. Health Rep 2001, 4, 23-32.
Forsen T, Eriksson J, Tuomilehto J, Osmond C, Barker D: Growth in utero and during childhood among women who develop coronary heart disease: longitudinal study. BMJ 1999, 319, 1403-1407.
Gale CR, Ashurst HE, Hall NF, MacCallum PK, Martyn CN: Sitze at birth and carotid atherosclerosis in later life. Atherosclerosis 2002, 1, 141-147.
Ginsburg BE, Zetterström R: Serum cholesterol concentrations in early infancy. Acta Pediatr Scand 1981, 69, 581-585.
Godfrey KM, Barker DJ: Fetal nutrition and adult disease. Am J Clin Nutr 2000, Suppl. 5, 1344S-1352S.
Abdul-Rahim HF, Husseini A, Bjertness E, Giacaman R, Gordon NH, Jervell J: The Metabolic Syndrome in the West Bank Population. An urban-rural comparison. Diabetes Care 2001, 24, 275-279.
Hardell L: Serum lipids and lipoproteins at birth based on a study of 2815 newborn infants. Concentrations and distributions of triglycerides and cholesterol. Acta Pediatr Scand Suppl 1981, 285, 5-10.
Hickman TB, Briefel RR, Carroll MD, Rifkind BM, Cleeman JI, Maurer KR, Johnson CL: Distributions and trends of serum lipid levels among United States children and adolescents ages 4-19 years: Data from the Third National Health and Nutrition Examination. Prev Med 1998, 6, 879-890.
Kędzierska I, Kędzierski W: Ekologiczna Profi laktyka Chorób Uwarunkowanych przez Czynniki Środowiskowe. Wydawnictwo Medyczne, Warszawa 1997.
Knuiman JT, Hermus RJJ, Hautvast JG: Serum total and high density lipoprotein (HDL) cholesterol concentrations in rural and urban boys from 16 countries. Atherosclerosis 1980, 36, 529-537.
Kwiterovich Jr PO: Detection and treatment of elevated blood lipids and other risk factors for coronary artery disease in youth. Ann N Y Acad Sci 1995, 748, 313-332.
Libby P: Changing concepts of atherogenesis. J Intern Med 2000, 247, 349-358.
Lloyd-Jones DM, Nam BH, D’Agostino RB Sr, Levy D, Murabito JM, Wang TJ, Wilson PW, O’Donnell CJ: Parental cardiovascular disease as a risk factor for cardiovascular disease in middle-aged adults: a prospective study of parents and offspring. JAMA 2004, 291(18), 2204-2211.
Michels KB: Early life predictors of chronic disease. J Womens Health 2003, 2, 157-161.
Pac-Kożuchowska E: Stężenie cholesterolu całkowitego, cholesterolu frakcji HDL, LDL i VLDL oraz trójglicerydów w surowicy krwi u dzieci w różnych grupach wieku. Pediatr Pol 1990, 3-4, 4-16.
Pac-Kożuchowska E: The concentration of lipids, lipoproteins and apolipoproteins in cord blood serum of newborns on the course of intrauterine period. Ann UMCS Sec. D 2003, 2, 25-32.
Phillips DI, Walker BR, Reynolds RM, Flanagan DE, Wood PJ, Osmond C, Barker DJ, Whorwood CB: Low birth weight predicts elevated plasma cortisol concentrations in adults from 3 populations. Hypertension 2000, 6, 1301-1306.
Porkka KVK, Viikari JSA, Taimela S, Dahl M, Akerblom HK: Tracking and predictiveness of serum lipid and lipoprotein measurements in childhood: A 12-year follow-up. The cardiovascular risk in young Finns study. Am J Epidemiol 1994, 12, 1096-1110.
Saner G, Yüksel T, Birgül I: The relationship between total cholesterol and lipoproteinns concentrations in cord blood. Nutr Rep Int 1981, 1, 181-186.
Stiernstrom EL, Holmberg S, Thelin A, Svardsudd K: A prospective study of morbidity and mortality rates among farmers and rural and urban nonfarmers. J Clin Epidemiol 2001, 54(2), 121-126.
Tatoń J: Miażdżyca – Zapobieganie w Praktyce Lekarskiej. Wydawnictwo Lekarskie PZWL, Warszawa 1996.
Van Biervliet JP, Vercaemst R, Keersgieter W, Vinaimont N, Caster H, Rosseneu M: Evolution of lipoprotein patterns in newborns. Acta Pediatr Scand 1980, 69, 593-596.
Zhao WH, Liu YJ, Shou HC, Chen LJ: Cholesterol concentrations in cord blood of newborn infants. Zhonghua Er Ke Za Zhi 2003, 2, 107-109.