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RESEARCH PAPER
 
CC BY-NC-ND 3.0
 
 

Decreased NK cell activity after partial vulvectomy in pregnant patient with vulvar intraepithelial neoplasia 3 (VIN3)

Malgorzata Jerzak 1  ,  
Monika Ohams 2,  
 
1
Department of Gynecology and Gynecological Oncology, Military Institute of Medicine, Warsaw, Poland
2
Department of Clinical Immunology, Transplantation Institute, University Medical School, Warsaw, Poland
Ann Agric Environ Med 2017;24(3):459–463
KEYWORDS:
ABSTRACT:
Introduction and objective:
The study presents the problem of immune disturbances in pregnant women with vulvar carcinoma in situ (VIN3).

Material and Methods:
NK cell and T reg activity in the study patient were analysed using flow cytometry.

Results:
Decreased NK cell activity and but increased T reg activity were observed after vulvectomy, with subsequent successful pregnancy outcome.

Conclusions:
Although vulvar cancer may influence immune cell activity, this issue merits further study.

CORRESPONDING AUTHOR:
Malgorzata Jerzak   
Department of Gynecology and Gynecological Oncology, Military Institute of Medicine, Warsaw, Poland
 
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